Objective
Modelling progression of the dengue illness phenotype. Replication of the SEM analysis presented in:
Park, S., Srikiatkhachorn, A., Kalayanarooj, S., Macareo, L., Green, S., Friedman, J. F., & Rothman, A. L. (2018). Use of structural equation models to predict dengue illness phenotype. PLoS Neglected Tropical Diseases, 12(10), 1–14. https://doi.org/10.1371/journal.pntd.0006799
The paper was worried about the evolution of the Dengue virus (DENV) infection, which, in severe cases, leads to Dengue Haemorrhagic Fever (DHF), characterized by fever, plasma leakage, bleeding diathesis, and thrombocytopenia. Platelet counts and hepatic parameters like ALT were monitored in three moments of time to model the progression of the phenotype in dengue illness.
Original method: SEM using Mplus 8 statistical software. SEM parameters were estimated using the weighted least squares means and variances adjusted estimator with the theta parameterization
Method applied in this analysis: CB-SEM with MLR estimator in R’s
package Lavaan. For simplicity, we are not discussing weighted models
yet in this post. So, note this is not an exact replication. We are
taking a lot of freedom in adjusting models and analysis here.
Data acquisition
library(openxlsx)
data<-read.xlsx("Park2018.xlsx")
Let’s explore the data structure.
str(data)
## 'data.frame': 257 obs. of 22 variables:
## $ age2 : chr "12-13" "4-5" "4-5" "8-9" ...
## $ sex : num 1 1 2 2 1 1 1 1 2 2 ...
## $ dengue : num 1 1 0 1 1 0 1 1 1 1 ...
## $ dhf : num 1 0 0 0 0 0 0 0 0 0 ...
## $ dhf34 : num 0 0 0 0 0 0 0 0 0 0 ...
## $ ast_m3 : num 25 38 27 167 29 39 32 48 36 35 ...
## $ alt_m3 : num 10 14 9 109 13 15 10 23 18 16 ...
## $ wbc_m3 : num 3600 7200 9200 2200 9500 8000 5200 5000 2800 6000 ...
## $ lymph_m3 : num 16 21 13 34 7 21 16 18 37 11 ...
## $ albumin_m3 : num 4.5 5.6 4.6 4.8 5 5.9 4.6 3.9 4 4.2 ...
## $ max_hct_m3 : num 42.5 38 37 40 38 40 42.5 39 38 40 ...
## $ platelets_m3: num 271000 272000 216000 227000 204000 287000 266000 307000 206000 273000 ...
## $ tourn_no_m3 : num 21 21 10 21 5 8 21 4 6 4 ...
## $ ast_m1 : num 53 36 26 248 34 35 43 43 240 97 ...
## $ alt_m1 : num 15 14 11 174 14 11 9 24 126 28 ...
## $ wbc_m1 : num 2300 5100 3800 1600 6500 7300 2800 3800 600 3300 ...
## $ lymph_m1 : num 32 60 41 39 61 45 24 35 42 32 ...
## $ albumin_m1 : num 4.3 4.6 3.7 4.5 4.9 4.9 3.9 3.8 4.4 4.5 ...
## $ max_hct_m1 : num 43 39 37 40 36 37 41 39 38 45 ...
## $ platelets_m1: num 73000 263000 200000 116000 163000 262000 168000 147000 180000 106000 ...
## $ tourn_no_m1 : num 21 21 0 21 2 4 21 20 14 21 ...
## $ age_t : num 12 4 4 8 6 4 8 8 4 6 ...
In this dataset, outcomes cannot be described by a single parameter, but by a set of complementary and possibly multicollinear parameters. Note also that the parameters are monitored and assessed multiple times over a specific period, as the time for results to become apparent can also vary. Such sequential measures are certainly associated. Notably, the intervention improves or worsens, but the ultimate level of results depends on the initial measure.
The same parameters (like platelet count and ALT levels) are assessed 3 days and 1 day before the event (indicated with m3 and m1 at the end of the variable name).
initial model:
library(lavaan)
model="
dhf~ast_m1+alt_m1+wbc_m1+lymph_m1+albumin_m1+max_hct_m1+platelets_m1+tourn_no_m1
ast_m1~ast_m3
alt_m1~alt_m3
wbc_m1~wbc_m3
lymph_m1~lymph_m3
albumin_m1~albumin_m3
max_hct_m1~max_hct_m3
platelets_m1~platelets_m3
tourn_no_m1~tourn_no_m3
alt_m3~age_t
wbc_m3~age_t
lymph_m3~age_t
max_hct_m3~age_t
platelets_m3~age_t
tourn_no_m3~age_t
"
fit=sem(model=model, data=data,std.ov=TRUE,estimator="MLR",fixed.x = FALSE)
the model reflect:
-
causal relation among DHF (dengue hemorrhagic fever) and measures 1 day before the event
-
the measures at 1 day before the event as potentially influenced by the same variable, measured at 3 days before the event.
-
hypotheses about the influence of age on measures at m3
-
For now, we are ignoring that measurements can be correlated with each other (eg ALT and AST are known enzymes associated with hepatotoxicity, for example).
Visualization
Visualization was generated using R’s package semPlots, with some
adjustment of the coordinates for each of the variables, and also adding
p values for paths.
Visualization generated with R’s package semPlots is the following:
#17 nodes
ly<-matrix(NA,18,2)
depVar='dhf'
med1=c('ast_m1','alt_m1','wbc_m1','lymph_m1','albumin_m1','max_hct_m1','platelets_m1','tourn_no_m1')
med2=c('ast_m3','alt_m3','wbc_m3','lymph_m3','albumin_m3','max_hct_m3','platelets_m3','tourn_no_m3')
indepVar='age_t'
labels=c()
labels[1]=depVar
ly[1,]=c(1,0)
y=1
for (x in c(1:length(med1))){
ly[y+x,]=c(0.6,(x/8*1.6-1))
labels[(x+y)]<-med1[x]
}
y=9
for (x in c(1:length(med2))){
ly[y+x,]=c(-1,(x/8*1.6-1))
labels[(x+y)]<-med2[x]
}
labels[18]=indepVar
ly[18,]=c(-0.5,1)
table2<-parameterEstimates(fit,standardized=TRUE)%>%as.data.frame()
table2<-table2[!table2$lhs==table2$rhs,]
b<-gettextf('%.3f \n p=%.3f', table2$std.all, digits=table2$pvalue)
semPaths(fit, layout=ly,
edgeLabels=b,
residuals=FALSE,
style='ram',
what='est',
whatLabels = "std",
cut=0.3,
sizeMan = 10, # Size of manifest variables
sizeMan2=3,edge.label.cex = 0.8,label.cex=1,
nCharNodes = 0,fade=TRUE,
mar = c(1,3,1,3))
Parameter table
The summarization on fit measures and parameter estimates are presented bellow.
summary(fit, fit.measures=TRUE)
## lavaan 0.6-12 ended normally after 1 iterations
##
## Estimator ML
## Optimization method NLMINB
## Number of model parameters 43
##
## Number of observations 257
##
## Model Test User Model:
## Standard Robust
## Test Statistic 935.588 688.731
## Degrees of freedom 128 128
## P-value (Chi-square) 0.000 0.000
## Scaling correction factor 1.358
## Yuan-Bentler correction (Mplus variant)
##
## Model Test Baseline Model:
##
## Test statistic 2022.763 1286.756
## Degrees of freedom 150 150
## P-value 0.000 0.000
## Scaling correction factor 1.572
##
## User Model versus Baseline Model:
##
## Comparative Fit Index (CFI) 0.569 0.507
## Tucker-Lewis Index (TLI) 0.495 0.422
##
## Robust Comparative Fit Index (CFI) 0.574
## Robust Tucker-Lewis Index (TLI) 0.500
##
## Loglikelihood and Information Criteria:
##
## Loglikelihood user model (H0) -6006.068 -6006.068
## Scaling correction factor 4.208
## for the MLR correction
## Loglikelihood unrestricted model (H1) -5538.274 -5538.274
## Scaling correction factor 2.075
## for the MLR correction
##
## Akaike (AIC) 12098.136 12098.136
## Bayesian (BIC) 12250.747 12250.747
## Sample-size adjusted Bayesian (BIC) 12114.424 12114.424
##
## Root Mean Square Error of Approximation:
##
## RMSEA 0.157 0.131
## 90 Percent confidence interval - lower 0.147 0.122
## 90 Percent confidence interval - upper 0.166 0.139
## P-value RMSEA <= 0.05 0.000 0.000
##
## Robust RMSEA 0.152
## 90 Percent confidence interval - lower 0.141
## 90 Percent confidence interval - upper 0.163
##
## Standardized Root Mean Square Residual:
##
## SRMR 0.167 0.167
##
## Parameter Estimates:
##
## Standard errors Sandwich
## Information bread Observed
## Observed information based on Hessian
##
## Regressions:
## Estimate Std.Err z-value P(>|z|)
## dhf ~
## ast_m1 0.076 0.112 0.674 0.500
## alt_m1 0.082 0.104 0.784 0.433
## wbc_m1 0.006 0.057 0.101 0.920
## lymph_m1 -0.082 0.058 -1.411 0.158
## albumin_m1 0.022 0.059 0.379 0.704
## max_hct_m1 0.186 0.058 3.224 0.001
## platelets_m1 -0.215 0.064 -3.358 0.001
## tourn_no_m1 0.156 0.058 2.665 0.008
## ast_m1 ~
## ast_m3 0.611 0.111 5.506 0.000
## alt_m1 ~
## alt_m3 0.639 0.185 3.450 0.001
## wbc_m1 ~
## wbc_m3 0.735 0.051 14.423 0.000
## lymph_m1 ~
## lymph_m3 0.419 0.058 7.265 0.000
## albumin_m1 ~
## albumin_m3 0.531 0.056 9.456 0.000
## max_hct_m1 ~
## max_hct_m3 0.581 0.073 7.953 0.000
## platelets_m1 ~
## platelets_m3 0.660 0.056 11.762 0.000
## tourn_no_m1 ~
## tourn_no_m3 0.526 0.051 10.302 0.000
## alt_m3 ~
## age_t 0.100 0.056 1.788 0.074
## wbc_m3 ~
## age_t -0.186 0.053 -3.523 0.000
## lymph_m3 ~
## age_t -0.345 0.061 -5.639 0.000
## max_hct_m3 ~
## age_t 0.341 0.061 5.618 0.000
## platelets_m3 ~
## age_t -0.274 0.062 -4.422 0.000
## tourn_no_m3 ~
## age_t 0.116 0.062 1.866 0.062
##
## Covariances:
## Estimate Std.Err z-value P(>|z|)
## ast_m3 ~~
## albumin_m3 -0.188 0.080 -2.360 0.018
## age_t -0.036 0.060 -0.594 0.553
## albumin_m3 ~~
## age_t 0.068 0.060 1.136 0.256
##
## Variances:
## Estimate Std.Err z-value P(>|z|)
## .dhf 0.781 0.075 10.464 0.000
## .ast_m1 0.624 0.408 1.532 0.125
## .alt_m1 0.590 0.165 3.577 0.000
## .wbc_m1 0.458 0.061 7.460 0.000
## .lymph_m1 0.821 0.082 10.067 0.000
## .albumin_m1 0.716 0.091 7.905 0.000
## .max_hct_m1 0.659 0.082 7.998 0.000
## .platelets_m1 0.562 0.052 10.910 0.000
## .tourn_no_m1 0.721 0.055 13.124 0.000
## .alt_m3 0.986 0.409 2.411 0.016
## .wbc_m3 0.962 0.248 3.882 0.000
## .lymph_m3 0.878 0.083 10.547 0.000
## .max_hct_m3 0.880 0.099 8.869 0.000
## .platelets_m3 0.922 0.091 10.103 0.000
## .tourn_no_m3 0.983 0.060 16.407 0.000
## ast_m3 0.996 0.428 2.329 0.020
## albumin_m3 0.996 0.102 9.727 0.000
## age_t 0.996 0.068 14.642 0.000
The fit measures can be also extracted using:
fitmeasures(fit)
## npar fmin
## 43.000 1.820
## chisq df
## 935.588 128.000
## pvalue chisq.scaled
## 0.000 688.731
## df.scaled pvalue.scaled
## 128.000 0.000
## chisq.scaling.factor baseline.chisq
## 1.358 2022.763
## baseline.df baseline.pvalue
## 150.000 0.000
## baseline.chisq.scaled baseline.df.scaled
## 1286.756 150.000
## baseline.pvalue.scaled baseline.chisq.scaling.factor
## 0.000 1.572
## cfi tli
## 0.569 0.495
## nnfi rfi
## 0.495 0.458
## nfi pnfi
## 0.537 0.459
## ifi rni
## 0.574 0.569
## cfi.scaled tli.scaled
## 0.507 0.422
## cfi.robust tli.robust
## 0.574 0.500
## nnfi.scaled nnfi.robust
## 0.422 0.500
## rfi.scaled nfi.scaled
## 0.373 0.465
## ifi.scaled rni.scaled
## 0.516 0.507
## rni.robust logl
## 0.574 -6006.068
## unrestricted.logl aic
## -5538.274 12098.136
## bic ntotal
## 12250.747 257.000
## bic2 scaling.factor.h1
## 12114.424 2.075
## scaling.factor.h0 rmsea
## 4.208 0.157
## rmsea.ci.lower rmsea.ci.upper
## 0.147 0.166
## rmsea.pvalue rmsea.scaled
## 0.000 0.131
## rmsea.ci.lower.scaled rmsea.ci.upper.scaled
## 0.122 0.139
## rmsea.pvalue.scaled rmsea.robust
## 0.000 0.152
## rmsea.ci.lower.robust rmsea.ci.upper.robust
## 0.141 0.163
## rmsea.pvalue.robust rmr
## NA 0.166
## rmr_nomean srmr
## 0.166 0.167
## srmr_bentler srmr_bentler_nomean
## 0.167 0.167
## crmr crmr_nomean
## 0.176 0.176
## srmr_mplus srmr_mplus_nomean
## 0.167 0.167
## cn_05 cn_01
## 43.689 47.185
## gfi agfi
## 0.746 0.661
## pgfi mfi
## 0.558 0.208
## ecvi
## 3.975
And parameter estimates can also obtained by:
parameterestimates(fit,standardized = TRUE)
## lhs op rhs est se z pvalue ci.lower ci.upper
## 1 dhf ~ ast_m1 0.076 0.112 0.674 0.500 -0.144 0.295
## 2 dhf ~ alt_m1 0.082 0.104 0.784 0.433 -0.122 0.285
## 3 dhf ~ wbc_m1 0.006 0.057 0.101 0.920 -0.107 0.118
## 4 dhf ~ lymph_m1 -0.082 0.058 -1.411 0.158 -0.195 0.032
## 5 dhf ~ albumin_m1 0.022 0.059 0.379 0.704 -0.093 0.138
## 6 dhf ~ max_hct_m1 0.186 0.058 3.224 0.001 0.073 0.299
## 7 dhf ~ platelets_m1 -0.215 0.064 -3.358 0.001 -0.341 -0.090
## 8 dhf ~ tourn_no_m1 0.156 0.058 2.665 0.008 0.041 0.270
## 9 ast_m1 ~ ast_m3 0.611 0.111 5.506 0.000 0.393 0.828
## 10 alt_m1 ~ alt_m3 0.639 0.185 3.450 0.001 0.276 1.002
## 11 wbc_m1 ~ wbc_m3 0.735 0.051 14.423 0.000 0.635 0.835
## 12 lymph_m1 ~ lymph_m3 0.419 0.058 7.265 0.000 0.306 0.532
## 13 albumin_m1 ~ albumin_m3 0.531 0.056 9.456 0.000 0.421 0.641
## 14 max_hct_m1 ~ max_hct_m3 0.581 0.073 7.953 0.000 0.438 0.725
## 15 platelets_m1 ~ platelets_m3 0.660 0.056 11.762 0.000 0.550 0.770
## 16 tourn_no_m1 ~ tourn_no_m3 0.526 0.051 10.302 0.000 0.426 0.626
## 17 alt_m3 ~ age_t 0.100 0.056 1.788 0.074 -0.010 0.210
## 18 wbc_m3 ~ age_t -0.186 0.053 -3.523 0.000 -0.289 -0.082
## 19 lymph_m3 ~ age_t -0.345 0.061 -5.639 0.000 -0.464 -0.225
## 20 max_hct_m3 ~ age_t 0.341 0.061 5.618 0.000 0.222 0.460
## 21 platelets_m3 ~ age_t -0.274 0.062 -4.422 0.000 -0.395 -0.152
## 22 tourn_no_m3 ~ age_t 0.116 0.062 1.866 0.062 -0.006 0.237
## 23 dhf ~~ dhf 0.781 0.075 10.464 0.000 0.635 0.927
## 24 ast_m1 ~~ ast_m1 0.624 0.408 1.532 0.125 -0.174 1.423
## 25 alt_m1 ~~ alt_m1 0.590 0.165 3.577 0.000 0.267 0.913
## 26 wbc_m1 ~~ wbc_m1 0.458 0.061 7.460 0.000 0.338 0.578
## 27 lymph_m1 ~~ lymph_m1 0.821 0.082 10.067 0.000 0.661 0.981
## 28 albumin_m1 ~~ albumin_m1 0.716 0.091 7.905 0.000 0.538 0.893
## 29 max_hct_m1 ~~ max_hct_m1 0.659 0.082 7.998 0.000 0.498 0.821
## 30 platelets_m1 ~~ platelets_m1 0.562 0.052 10.910 0.000 0.461 0.663
## 31 tourn_no_m1 ~~ tourn_no_m1 0.721 0.055 13.124 0.000 0.613 0.828
## 32 alt_m3 ~~ alt_m3 0.986 0.409 2.411 0.016 0.184 1.788
## 33 wbc_m3 ~~ wbc_m3 0.962 0.248 3.882 0.000 0.476 1.447
## 34 lymph_m3 ~~ lymph_m3 0.878 0.083 10.547 0.000 0.715 1.041
## 35 max_hct_m3 ~~ max_hct_m3 0.880 0.099 8.869 0.000 0.686 1.075
## 36 platelets_m3 ~~ platelets_m3 0.922 0.091 10.103 0.000 0.743 1.100
## 37 tourn_no_m3 ~~ tourn_no_m3 0.983 0.060 16.407 0.000 0.865 1.100
## 38 ast_m3 ~~ ast_m3 0.996 0.428 2.329 0.020 0.158 1.834
## 39 ast_m3 ~~ albumin_m3 -0.188 0.080 -2.360 0.018 -0.344 -0.032
## 40 ast_m3 ~~ age_t -0.036 0.060 -0.594 0.553 -0.153 0.082
## 41 albumin_m3 ~~ albumin_m3 0.996 0.102 9.727 0.000 0.795 1.197
## 42 albumin_m3 ~~ age_t 0.068 0.060 1.136 0.256 -0.050 0.186
## 43 age_t ~~ age_t 0.996 0.068 14.642 0.000 0.863 1.129
## std.lv std.all std.nox
## 1 0.076 0.079 0.079
## 2 0.082 0.085 0.085
## 3 0.006 0.006 0.006
## 4 -0.082 -0.085 -0.085
## 5 0.022 0.023 0.023
## 6 0.186 0.194 0.194
## 7 -0.215 -0.225 -0.225
## 8 0.156 0.163 0.163
## 9 0.611 0.611 0.612
## 10 0.639 0.639 0.639
## 11 0.735 0.735 0.735
## 12 0.419 0.419 0.419
## 13 0.531 0.531 0.532
## 14 0.581 0.581 0.581
## 15 0.660 0.660 0.660
## 16 0.526 0.526 0.526
## 17 0.100 0.100 0.100
## 18 -0.186 -0.186 -0.186
## 19 -0.345 -0.345 -0.345
## 20 0.341 0.341 0.342
## 21 -0.274 -0.274 -0.274
## 22 0.116 0.116 0.116
## 23 0.781 0.856 0.856
## 24 0.624 0.627 0.627
## 25 0.590 0.592 0.592
## 26 0.458 0.460 0.460
## 27 0.821 0.824 0.824
## 28 0.716 0.718 0.718
## 29 0.659 0.662 0.662
## 30 0.562 0.565 0.565
## 31 0.721 0.724 0.724
## 32 0.986 0.990 0.990
## 33 0.962 0.965 0.965
## 34 0.878 0.881 0.881
## 35 0.880 0.883 0.883
## 36 0.922 0.925 0.925
## 37 0.983 0.987 0.987
## 38 0.996 1.000 0.996
## 39 -0.188 -0.189 -0.188
## 40 -0.036 -0.036 -0.036
## 41 0.996 1.000 0.996
## 42 0.068 0.069 0.068
## 43 0.996 1.000 0.996
Testing forced orthogonality
The lavaan’s ‘sem’ function set the remaining paths free for covariance estimation. But in some tools, like in those interface/graphics- oriented tools, not drawn covariates are set as zero, forcing orthogonality. The following code attempt to do so using a lavaan’s function just for illustration. Note how an error message is thrown.
fit_forcedOrth=try(lavaan(model=model, data=data,std.ov=TRUE,estimator="MLR",fixed.x = FALSE,orthogonal.x=TRUE))
## Warning in lav_start_check_cov(lavpartable = lavpartable, start = START): lavaan WARNING: non-zero covariance element set to zero, due to fixed-to-zero variances
## variables involved are: ast_m3 albumin_m3
## Warning in lav_start_check_cov(lavpartable = lavpartable, start = START): lavaan WARNING: non-zero covariance element set to zero, due to fixed-to-zero variances
## variables involved are: ast_m3 age_t
## Warning in lav_start_check_cov(lavpartable = lavpartable, start = START): lavaan WARNING: non-zero covariance element set to zero, due to fixed-to-zero variances
## variables involved are: albumin_m3 age_t
## [,1] [,2] [,3] [,4] [,5] [,6] [,7] [,8] [,9] [,10] [,11] [,12] [,13]
## [1,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [2,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [3,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [4,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [5,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [6,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [7,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [8,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [9,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [10,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [11,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [12,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [13,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [14,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [15,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [16,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [17,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [18,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [,14] [,15] [,16] [,17] [,18]
## [1,] 0 0 0 0 0
## [2,] 0 0 0 0 0
## [3,] 0 0 0 0 0
## [4,] 0 0 0 0 0
## [5,] 0 0 0 0 0
## [6,] 0 0 0 0 0
## [7,] 0 0 0 0 0
## [8,] 0 0 0 0 0
## [9,] 0 0 0 0 0
## [10,] 0 0 0 0 0
## [11,] 0 0 0 0 0
## [12,] 0 0 0 0 0
## [13,] 0 0 0 0 0
## [14,] 0 0 0 0 0
## [15,] 0 0 0 0 0
## [16,] 0 0 0 0 0
## [17,] 0 0 0 0 0
## [18,] 0 0 0 0 0
## [,1] [,2] [,3] [,4] [,5] [,6] [,7] [,8] [,9] [,10] [,11] [,12] [,13]
## [1,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [2,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [3,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [4,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [5,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [6,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [7,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [8,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [9,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [10,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [11,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [12,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [13,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [14,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [15,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [16,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [17,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [18,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [,14] [,15] [,16] [,17] [,18]
## [1,] 0 0 0 0 0
## [2,] 0 0 0 0 0
## [3,] 0 0 0 0 0
## [4,] 0 0 0 0 0
## [5,] 0 0 0 0 0
## [6,] 0 0 0 0 0
## [7,] 0 0 0 0 0
## [8,] 0 0 0 0 0
## [9,] 0 0 0 0 0
## [10,] 0 0 0 0 0
## [11,] 0 0 0 0 0
## [12,] 0 0 0 0 0
## [13,] 0 0 0 0 0
## [14,] 0 0 0 0 0
## [15,] 0 0 0 0 0
## [16,] 0 0 0 0 0
## [17,] 0 0 0 0 0
## [18,] 0 0 0 0 0
## [,1] [,2] [,3] [,4] [,5] [,6] [,7] [,8] [,9] [,10] [,11] [,12] [,13]
## [1,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [2,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [3,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [4,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [5,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [6,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [7,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [8,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [9,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [10,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [11,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [12,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [13,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [14,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [15,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [16,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [17,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [18,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [,14] [,15] [,16] [,17] [,18]
## [1,] 0 0 0 0 0
## [2,] 0 0 0 0 0
## [3,] 0 0 0 0 0
## [4,] 0 0 0 0 0
## [5,] 0 0 0 0 0
## [6,] 0 0 0 0 0
## [7,] 0 0 0 0 0
## [8,] 0 0 0 0 0
## [9,] 0 0 0 0 0
## [10,] 0 0 0 0 0
## [11,] 0 0 0 0 0
## [12,] 0 0 0 0 0
## [13,] 0 0 0 0 0
## [14,] 0 0 0 0 0
## [15,] 0 0 0 0 0
## [16,] 0 0 0 0 0
## [17,] 0 0 0 0 0
## [18,] 0 0 0 0 0
## [,1] [,2] [,3] [,4] [,5] [,6] [,7] [,8] [,9] [,10] [,11] [,12] [,13]
## [1,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [2,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [3,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [4,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [5,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [6,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [7,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [8,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [9,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [10,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [11,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [12,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [13,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [14,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [15,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [16,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [17,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [18,] 0 0 0 0 0 0 0 0 0 0 0 0 0
## [,14] [,15] [,16] [,17] [,18]
## [1,] 0 0 0 0 0
## [2,] 0 0 0 0 0
## [3,] 0 0 0 0 0
## [4,] 0 0 0 0 0
## [5,] 0 0 0 0 0
## [6,] 0 0 0 0 0
## [7,] 0 0 0 0 0
## [8,] 0 0 0 0 0
## [9,] 0 0 0 0 0
## [10,] 0 0 0 0 0
## [11,] 0 0 0 0 0
## [12,] 0 0 0 0 0
## [13,] 0 0 0 0 0
## [14,] 0 0 0 0 0
## [15,] 0 0 0 0 0
## [16,] 0 0 0 0 0
## [17,] 0 0 0 0 0
## [18,] 0 0 0 0 0
## Warning in lavaan(model = model, data = data, std.ov = TRUE, estimator = "MLR", : lavaan WARNING:
## Model estimation FAILED! Returning starting values.
## Error in Sigma.inv * sample.cov : non-conformable arrays
Adjustments
Note that the fit measures does not indicate a good fit (following filter the fit measures to some key ones):
fitmeasures(fit)[c('cfi.robust','tli.robust','rmsea.robust','rmsea.ci.lower.robust' , 'rmsea.ci.upper.robust')]
## cfi.robust tli.robust rmsea.robust
## 0.5737408 0.5004775 0.1521680
## rmsea.ci.lower.robust rmsea.ci.upper.robust
## 0.1411162 0.1634234
The above fit measures indicate the model-implied covariance-matrix does not fit well with the sample covariance matrix.
Any attempt to make interpretations on the parameter table can be useless, whereas the fit measures do not show at least a reasonable fit.
Residual covariances
As mentioned, the fit measures reflect how the model-implied covariance matrix and sample covariance matrix are close or not. Consequently, we can talk about residual covarinces.
lavResiduals(fit,zstat=TRUE, type='cor')
## $type
## [1] "cor.bollen"
##
## $cov
## dhf ast_m1 alt_m1 wbc_m1 lymp_1 albm_1 mx_h_1 pltl_1 trn__1
## dhf 0.000
## ast_m1 0.132 0.000
## alt_m1 0.148 0.777 0.000
## wbc_m1 -0.150 -0.066 -0.095 0.000
## lymph_m1 -0.028 -0.020 -0.037 -0.259 0.000
## albumin_m1 -0.098 -0.015 -0.130 -0.025 0.026 0.000
## max_hct_m1 0.088 -0.040 0.047 -0.141 -0.103 -0.009 0.000
## platelets_m1 -0.100 -0.242 -0.247 0.476 -0.080 0.280 -0.260 0.000
## tourn_no_m1 0.124 0.171 0.207 -0.186 -0.163 -0.136 0.208 -0.250 0.000
## alt_m3 0.100 0.339 0.000 -0.040 -0.021 -0.192 0.068 -0.152 0.154
## wbc_m3 -0.187 -0.169 -0.202 0.000 -0.281 0.072 -0.095 0.437 -0.234
## lymph_m3 0.023 -0.026 0.012 -0.130 0.000 -0.043 -0.170 -0.117 -0.040
## max_hct_m3 -0.033 0.090 0.120 -0.039 -0.129 -0.006 0.000 -0.090 0.111
## platelets_m3 -0.013 -0.247 -0.227 0.289 -0.061 0.219 -0.172 0.000 -0.160
## tourn_no_m3 0.099 0.075 0.075 -0.125 -0.008 -0.096 0.015 -0.132 0.000
## ast_m3 0.165 0.000 0.692 0.003 0.006 -0.142 -0.040 -0.216 0.204
## albumin_m3 0.018 -0.036 -0.209 -0.107 0.006 0.000 0.023 0.087 -0.099
## age_t 0.071 0.051 0.079 -0.145 -0.118 0.012 0.219 -0.076 0.170
## alt_m3 wbc_m3 lymp_3 mx_h_3 pltl_3 trn__3 ast_m3 albm_3 age_t
## dhf
## ast_m1
## alt_m1
## wbc_m1
## lymph_m1
## albumin_m1
## max_hct_m1
## platelets_m1
## tourn_no_m1
## alt_m3 0.000
## wbc_m3 -0.131 0.000
## lymph_m3 0.020 -0.397 0.000
## max_hct_m3 0.084 -0.013 -0.031 0.000
## platelets_m3 -0.106 0.319 -0.174 -0.091 0.000
## tourn_no_m3 0.033 -0.203 0.141 0.056 -0.049 0.000
## ast_m3 0.745 -0.214 0.087 0.104 -0.206 0.123 0.000
## albumin_m3 -0.174 0.066 -0.094 0.139 0.180 -0.032 0.000 0.000
## age_t 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
##
## $cov.z
## dhf ast_m1 alt_m1 wbc_m1 lymp_1 albm_1 mx_h_1 pltl_1 trn__1
## dhf 0.000
## ast_m1 0.817 0.000
## alt_m1 2.319 0.987 0.000
## wbc_m1 -3.128 -0.938 -1.460 0.000
## lymph_m1 -0.858 -0.236 -0.498 -3.061 0.000
## albumin_m1 -2.324 -0.147 -1.148 -0.517 0.409 0.000
## max_hct_m1 2.544 -0.530 0.746 -2.567 -1.675 -0.136 0.000
## platelets_m1 -2.586 -2.537 -2.295 3.431 -1.332 3.419 -3.356 0.000
## tourn_no_m1 4.914 1.684 1.730 -2.588 -2.630 -2.083 3.143 -3.111 0.000
## alt_m3 1.591 0.998 0.000 -0.716 -0.370 -1.515 0.955 -1.958 1.499
## wbc_m3 -2.682 -2.265 -2.181 0.000 -2.944 1.109 -1.642 3.369 -2.855
## lymph_m3 0.376 -0.469 0.284 -2.223 0.000 -0.708 -3.086 -2.010 -0.707
## max_hct_m3 -0.480 0.519 0.782 -0.567 -2.096 -0.085 0.000 -1.420 1.684
## platelets_m3 -0.292 -1.362 -1.425 3.005 -0.977 3.185 -2.572 0.000 -2.213
## tourn_no_m3 1.793 1.671 1.501 -1.905 -0.130 -1.522 0.256 -1.850 0.000
## ast_m3 0.926 0.000 0.907 0.036 0.078 -2.280 -0.564 -2.020 1.391
## albumin_m3 0.328 -0.358 -1.519 -1.747 0.098 0.000 0.448 1.596 -1.535
## age_t 1.331 0.687 0.912 -2.490 -1.893 0.190 3.751 -1.229 2.932
## alt_m3 wbc_m3 lymp_3 mx_h_3 pltl_3 trn__3 ast_m3 albm_3 age_t
## dhf
## ast_m1
## alt_m1
## wbc_m1
## lymph_m1
## albumin_m1
## max_hct_m1
## platelets_m1
## tourn_no_m1
## alt_m3 0.000
## wbc_m3 -2.109 0.000
## lymph_m3 0.465 -4.005 0.000
## max_hct_m3 0.780 -0.245 -0.542 0.000
## platelets_m3 -1.143 3.187 -2.490 -1.305 0.000
## tourn_no_m3 0.615 -2.805 2.223 0.915 -0.743 0.000
## ast_m3 1.050 -1.853 1.675 0.508 -1.079 1.629 0.000
## albumin_m3 -1.411 1.334 -1.617 2.242 2.516 -0.504 0.000 0.000
## age_t 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
##
## $summary
## cov
## crmr 0.176
## crmr.se 0.071
## crmr.exactfit.z 0.794
## crmr.exactfit.pvalue 0.214
## ucrmr 0.131
## ucrmr.se 0.121
## ucrmr.ci.lower -0.067
## ucrmr.cilupper 0.329
## ucrmr.closefit.h0.value 0.050
## ucrmr.closefit.z 0.671
## ucrmr.closefit.pvalue 0.251
But note the attempt to adjust based in this matrix can be really messy.
Modification indices
To adjust further the model, one useful output is the modification indices:
modificationindices(fit,standardized = TRUE)%>%arrange(-mi)
## lhs op rhs mi epc sepc.lv sepc.all sepc.nox
## 1 alt_m3 ~ ast_m3 144.348 0.746 0.746 0.746 0.748
## 2 ast_m3 ~ alt_m3 136.768 0.720 0.720 0.720 0.720
## 3 alt_m1 ~ ast_m1 136.180 0.560 0.560 0.560 0.560
## 4 ast_m1 ~~ alt_m1 126.805 0.426 0.426 0.702 0.702
## 5 ast_m3 ~ alt_m1 114.892 0.658 0.658 0.658 0.658
## 6 ast_m1 ~ alt_m1 51.312 0.354 0.354 0.354 0.354
## 7 wbc_m3 ~ platelets_m1 49.241 0.437 0.437 0.437 0.437
## 8 lymph_m3 ~ wbc_m3 47.503 -0.411 -0.411 -0.411 -0.411
## 9 wbc_m3 ~~ lymph_m3 47.503 -0.395 -0.395 -0.430 -0.430
## 10 wbc_m3 ~ lymph_m3 47.503 -0.450 -0.450 -0.450 -0.450
## 11 age_t ~ alt_m3 41.209 5.545 5.545 5.545 5.545
## 12 platelets_m1 ~ wbc_m1 37.130 0.286 0.286 0.286 0.286
## 13 wbc_m3 ~~ platelets_m3 29.204 0.317 0.317 0.337 0.337
## 14 wbc_m3 ~ platelets_m3 29.204 0.344 0.344 0.344 0.344
## 15 platelets_m3 ~ wbc_m3 29.204 0.330 0.330 0.330 0.330
## 16 alt_m3 ~ ast_m1 29.003 0.334 0.334 0.334 0.334
## 17 wbc_m3 ~ lymph_m1 24.912 -0.309 -0.309 -0.309 -0.309
## 18 platelets_m1 ~ wbc_m3 23.496 0.227 0.227 0.227 0.227
## 19 platelets_m1 ~~ wbc_m3 21.352 0.212 0.212 0.288 0.288
## 20 max_hct_m1 ~ age_t 21.000 0.247 0.247 0.247 0.248
## 21 max_hct_m1 ~~ max_hct_m3 21.000 -0.638 -0.638 -0.837 -0.837
## 22 max_hct_m3 ~ max_hct_m1 21.000 -0.967 -0.967 -0.967 -0.967
## 23 age_t ~ max_hct_m1 20.575 0.368 0.368 0.368 0.368
## 24 alt_m1 ~ ast_m3 20.326 0.216 0.216 0.216 0.217
## 25 albumin_m1 ~ platelets_m1 19.527 0.234 0.234 0.234 0.234
## 26 platelets_m3 ~ wbc_m1 17.671 0.255 0.255 0.255 0.255
## 27 max_hct_m1 ~ platelets_m1 16.870 -0.209 -0.209 -0.209 -0.209
## 28 wbc_m3 ~ dhf 16.281 -0.351 -0.351 -0.336 -0.336
## 29 platelets_m3 ~ ast_m1 15.107 -0.233 -0.233 -0.233 -0.233
## 30 wbc_m1 ~ lymph_m3 14.663 0.162 0.162 0.162 0.162
## 31 albumin_m1 ~~ platelets_m1 14.651 0.151 0.151 0.239 0.239
## 32 wbc_m1 ~ ast_m3 14.392 0.160 0.160 0.160 0.161
## 33 age_t ~ platelets_m3 14.338 -3.384 -3.384 -3.384 -3.384
## 34 tourn_no_m1 ~ max_hct_m1 14.196 0.200 0.200 0.200 0.200
## 35 wbc_m1 ~~ platelets_m1 13.932 0.118 0.118 0.233 0.233
## 36 max_hct_m1 ~ dhf 13.808 0.316 0.316 0.303 0.303
## 37 platelets_m3 ~ albumin_m1 13.740 0.223 0.223 0.223 0.223
## 38 wbc_m1 ~ albumin_m3 13.526 -0.156 -0.156 -0.156 -0.156
## 39 wbc_m1 ~ platelets_m1 13.460 0.155 0.155 0.155 0.155
## 40 lymph_m1 ~ wbc_m1 13.118 -0.205 -0.205 -0.205 -0.205
## 41 ast_m3 ~ dhf 12.827 0.279 0.279 0.267 0.267
## 42 max_hct_m1 ~~ tourn_no_m1 12.430 0.152 0.152 0.220 0.220
## 43 wbc_m3 ~ ast_m3 12.173 -0.214 -0.214 -0.214 -0.214
## 44 wbc_m1 ~~ wbc_m3 12.133 -0.776 -0.776 -1.169 -1.169
## 45 wbc_m1 ~ age_t 12.133 -0.150 -0.150 -0.150 -0.150
## 46 wbc_m3 ~ wbc_m1 12.133 -1.695 -1.695 -1.695 -1.695
## 47 age_t ~ tourn_no_m1 11.865 0.253 0.253 0.253 0.253
## 48 platelets_m3 ~ ast_m3 11.845 -0.207 -0.207 -0.207 -0.207
## 49 albumin_m1 ~ dhf 11.749 -0.307 -0.307 -0.293 -0.293
## 50 platelets_m3 ~ alt_m1 11.728 -0.206 -0.206 -0.206 -0.206
## 51 tourn_no_m1 ~ platelets_m1 11.529 -0.180 -0.180 -0.180 -0.180
## 52 max_hct_m1 ~~ platelets_m1 11.503 -0.129 -0.129 -0.212 -0.212
## 53 ast_m3 ~ platelets_m1 11.225 -0.209 -0.209 -0.209 -0.209
## 54 ast_m3 ~ wbc_m3 11.204 -0.209 -0.209 -0.209 -0.209
## 55 wbc_m3 ~~ tourn_no_m3 11.169 -0.203 -0.203 -0.208 -0.208
## 56 wbc_m3 ~ tourn_no_m3 11.169 -0.206 -0.206 -0.206 -0.206
## 57 tourn_no_m3 ~ wbc_m3 11.169 -0.211 -0.211 -0.211 -0.211
## 58 alt_m1 ~ platelets_m3 10.995 -0.159 -0.159 -0.159 -0.159
## 59 age_t ~ wbc_m1 10.983 -0.309 -0.309 -0.309 -0.309
## 60 wbc_m3 ~ tourn_no_m1 10.973 -0.203 -0.203 -0.203 -0.203
## 61 tourn_no_m1 ~ age_t 10.418 0.172 0.172 0.172 0.173
## 62 tourn_no_m1 ~~ tourn_no_m3 10.418 -1.467 -1.467 -1.743 -1.743
## 63 tourn_no_m3 ~ tourn_no_m1 10.418 -2.035 -2.035 -2.035 -2.035
## 64 platelets_m1 ~ dhf 10.172 -0.231 -0.231 -0.221 -0.221
## 65 tourn_no_m1 ~ alt_m1 9.988 0.168 0.168 0.168 0.168
## 66 wbc_m1 ~~ lymph_m1 9.873 -0.120 -0.120 -0.196 -0.196
## 67 platelets_m1 ~ max_hct_m1 9.856 -0.147 -0.147 -0.147 -0.147
## 68 alt_m1 ~ platelets_m1 9.793 -0.150 -0.150 -0.150 -0.150
## 69 alt_m3 ~ albumin_m1 9.723 -0.194 -0.194 -0.194 -0.194
## 70 lymph_m3 ~ wbc_m1 9.605 -0.183 -0.183 -0.183 -0.183
## 71 ast_m3 ~ tourn_no_m1 9.553 0.190 0.190 0.190 0.190
## 72 platelets_m3 ~ lymph_m3 9.526 -0.197 -0.197 -0.197 -0.197
## 73 lymph_m3 ~ platelets_m3 9.526 -0.188 -0.188 -0.188 -0.188
## 74 lymph_m3 ~~ platelets_m3 9.526 -0.173 -0.173 -0.193 -0.193
## 75 platelets_m1 ~ tourn_no_m1 9.426 -0.144 -0.144 -0.144 -0.144
## 76 wbc_m3 ~ alt_m1 9.423 -0.189 -0.189 -0.189 -0.189
## 77 max_hct_m1 ~ lymph_m3 9.103 -0.154 -0.154 -0.154 -0.154
## 78 platelets_m3 ~ albumin_m3 9.025 0.181 0.181 0.181 0.181
## 79 tourn_no_m1 ~ lymph_m1 8.959 -0.159 -0.159 -0.159 -0.159
## 80 alt_m1 ~~ platelets_m3 8.861 -0.137 -0.137 -0.186 -0.186
## 81 ast_m3 ~ platelets_m3 8.596 -0.187 -0.187 -0.187 -0.187
## 82 platelets_m1 ~ albumin_m1 8.316 0.135 0.135 0.135 0.135
## 83 max_hct_m1 ~ tourn_no_m1 7.929 0.143 0.143 0.143 0.143
## 84 wbc_m1 ~~ lymph_m3 7.921 0.111 0.111 0.176 0.176
## 85 alt_m3 ~ albumin_m3 7.914 -0.175 -0.175 -0.175 -0.175
## 86 albumin_m3 ~ max_hct_m3 7.566 0.179 0.179 0.179 0.179
## 87 albumin_m1 ~ ast_m3 7.511 -0.148 -0.148 -0.148 -0.148
## 88 ast_m3 ~ albumin_m1 7.486 -0.198 -0.198 -0.198 -0.198
## 89 alt_m1 ~ dhf 7.347 0.195 0.195 0.187 0.187
## 90 albumin_m3 ~ albumin_m1 7.023 -0.962 -0.962 -0.962 -0.962
## 91 tourn_no_m1 ~ ast_m3 6.853 0.139 0.139 0.139 0.139
## 92 wbc_m3 ~ ast_m1 6.739 -0.159 -0.159 -0.159 -0.159
## 93 lymph_m1 ~ tourn_no_m1 6.647 -0.146 -0.146 -0.146 -0.146
## 94 tourn_no_m1 ~ alt_m3 6.644 0.137 0.137 0.137 0.137
## 95 tourn_no_m1 ~ dhf 6.586 0.240 0.240 0.230 0.230
## 96 tourn_no_m1 ~ platelets_m3 6.428 -0.135 -0.135 -0.135 -0.135
## 97 albumin_m1 ~~ platelets_m3 6.220 0.126 0.126 0.156 0.156
## 98 lymph_m3 ~ platelets_m1 6.212 -0.148 -0.148 -0.148 -0.148
## 99 tourn_no_m1 ~ ast_m1 6.156 0.132 0.132 0.132 0.132
## 100 alt_m1 ~ wbc_m3 6.135 -0.119 -0.119 -0.119 -0.119
## 101 ast_m1 ~~ alt_m3 6.068 -0.121 -0.121 -0.154 -0.154
## 102 lymph_m1 ~~ wbc_m3 6.015 -0.136 -0.136 -0.153 -0.153
## 103 ast_m1 ~ platelets_m3 6.005 -0.121 -0.121 -0.121 -0.121
## 104 tourn_no_m3 ~ lymph_m3 5.843 0.160 0.160 0.160 0.160
## 105 lymph_m3 ~ tourn_no_m3 5.843 0.143 0.143 0.143 0.143
## 106 lymph_m3 ~~ tourn_no_m3 5.843 0.140 0.140 0.151 0.151
## 107 albumin_m3 ~ platelets_m3 5.776 0.153 0.153 0.153 0.153
## 108 tourn_no_m1 ~ wbc_m3 5.758 -0.127 -0.127 -0.127 -0.127
## 109 max_hct_m3 ~ albumin_m3 5.622 0.139 0.139 0.139 0.140
## 110 alt_m3 ~ platelets_m1 5.591 -0.149 -0.149 -0.149 -0.149
## 111 max_hct_m1 ~ platelets_m3 5.574 -0.120 -0.120 -0.120 -0.120
## 112 ast_m1 ~ alt_m3 5.512 -0.116 -0.116 -0.116 -0.116
## 113 albumin_m1 ~ platelets_m3 5.467 0.124 0.124 0.124 0.124
## 114 max_hct_m1 ~ wbc_m1 5.443 -0.119 -0.119 -0.119 -0.119
## 115 lymph_m1 ~~ tourn_no_m1 5.295 -0.110 -0.110 -0.144 -0.144
## 116 platelets_m1 ~~ tourn_no_m1 5.255 -0.091 -0.091 -0.143 -0.143
## 117 age_t ~ alt_m1 5.217 0.185 0.185 0.185 0.185
## 118 tourn_no_m1 ~ wbc_m1 5.168 -0.121 -0.121 -0.121 -0.121
## 119 tourn_no_m1 ~~ alt_m3 5.144 0.119 0.119 0.141 0.141
## 120 alt_m1 ~ tourn_no_m1 5.119 0.109 0.109 0.109 0.109
## 121 ast_m3 ~ max_hct_m3 5.085 0.147 0.147 0.147 0.147
## 122 ast_m1 ~~ platelets_m3 5.082 -0.107 -0.107 -0.141 -0.141
## 123 ast_m1 ~ platelets_m1 4.948 -0.110 -0.110 -0.110 -0.110
## 124 age_t ~ lymph_m1 4.941 -0.162 -0.162 -0.162 -0.162
## 125 alt_m3 ~ tourn_no_m1 4.907 0.138 0.138 0.138 0.138
## 126 lymph_m3 ~ lymph_m1 4.905 -0.415 -0.415 -0.415 -0.415
## 127 lymph_m1 ~ age_t 4.905 -0.134 -0.134 -0.134 -0.134
## 128 lymph_m1 ~~ lymph_m3 4.905 -0.340 -0.340 -0.401 -0.401
## 129 alt_m1 ~~ wbc_m3 4.876 -0.104 -0.104 -0.138 -0.138
## 130 ast_m1 ~~ albumin_m1 4.736 0.091 0.091 0.136 0.136
## 131 tourn_no_m1 ~ lymph_m3 4.653 -0.115 -0.115 -0.115 -0.115
## 132 alt_m3 ~~ wbc_m3 4.608 -0.130 -0.130 -0.134 -0.134
## 133 wbc_m3 ~ alt_m3 4.608 -0.132 -0.132 -0.132 -0.132
## 134 alt_m3 ~ wbc_m3 4.608 -0.136 -0.136 -0.136 -0.136
## 135 platelets_m1 ~ tourn_no_m3 4.540 -0.100 -0.100 -0.100 -0.100
## 136 age_t ~ wbc_m3 4.377 -1.830 -1.830 -1.830 -1.830
## 137 platelets_m1 ~ alt_m1 4.339 -0.098 -0.098 -0.098 -0.098
## 138 lymph_m1 ~ max_hct_m3 4.251 -0.118 -0.118 -0.118 -0.118
## 139 alt_m1 ~ albumin_m3 4.170 -0.098 -0.098 -0.098 -0.098
## 140 lymph_m1 ~ wbc_m3 4.112 -0.115 -0.115 -0.115 -0.115
## 141 dhf ~ max_hct_m3 4.097 -0.138 -0.138 -0.144 -0.144
## 142 dhf ~~ max_hct_m1 4.097 0.156 0.156 0.218 0.218
## 143 tourn_no_m3 ~ platelets_m1 4.087 -0.127 -0.127 -0.127 -0.127
## 144 alt_m3 ~ dhf 4.060 0.164 0.164 0.157 0.157
## 145 tourn_no_m3 ~ ast_m3 3.942 0.123 0.123 0.123 0.123
## 146 max_hct_m1 ~ ast_m3 3.932 -0.101 -0.101 -0.101 -0.101
## 147 alt_m1 ~~ tourn_no_m1 3.871 0.080 0.080 0.123 0.123
## 148 platelets_m1 ~~ tourn_no_m3 3.825 -0.091 -0.091 -0.122 -0.122
## 149 ast_m3 ~ tourn_no_m3 3.701 0.119 0.119 0.119 0.119
## 150 age_t ~ platelets_m1 3.685 -0.165 -0.165 -0.165 -0.165
## 151 albumin_m1 ~~ alt_m3 3.685 -0.101 -0.101 -0.120 -0.120
## 152 age_t ~ lymph_m3 3.645 1.748 1.748 1.748 1.748
## 153 platelets_m3 ~ max_hct_m1 3.645 -0.117 -0.117 -0.117 -0.117
## 154 platelets_m3 ~ tourn_no_m1 3.594 -0.114 -0.114 -0.114 -0.114
## 155 albumin_m1 ~ alt_m3 3.563 -0.100 -0.100 -0.100 -0.100
## 156 dhf ~~ max_hct_m3 3.505 -0.116 -0.116 -0.140 -0.140
## 157 tourn_no_m3 ~ dhf 3.452 0.141 0.141 0.135 0.135
## 158 wbc_m1 ~ albumin_m1 3.406 -0.078 -0.078 -0.078 -0.078
## 159 tourn_no_m1 ~~ wbc_m3 3.368 -0.095 -0.095 -0.114 -0.114
## 160 max_hct_m1 ~ ast_m1 3.294 -0.092 -0.092 -0.092 -0.092
## 161 alt_m3 ~~ platelets_m3 3.147 -0.105 -0.105 -0.111 -0.111
## 162 alt_m3 ~ platelets_m3 3.147 -0.114 -0.114 -0.114 -0.114
## 163 platelets_m3 ~ alt_m3 3.147 -0.107 -0.107 -0.107 -0.107
## 164 max_hct_m3 ~ ast_m3 3.141 0.104 0.104 0.104 0.104
## 165 tourn_no_m3 ~ wbc_m1 3.100 -0.110 -0.110 -0.110 -0.110
## 166 platelets_m1 ~ alt_m3 3.068 -0.082 -0.082 -0.082 -0.082
## 167 max_hct_m1 ~ wbc_m3 3.023 -0.088 -0.088 -0.088 -0.088
## 168 tourn_no_m1 ~~ platelets_m3 2.968 -0.088 -0.088 -0.107 -0.107
## 169 platelets_m1 ~ ast_m3 2.924 -0.080 -0.080 -0.080 -0.080
## 170 platelets_m1 ~ ast_m1 2.838 -0.079 -0.079 -0.079 -0.079
## 171 platelets_m1 ~ age_t 2.830 -0.082 -0.082 -0.082 -0.082
## 172 platelets_m1 ~~ platelets_m3 2.830 -0.276 -0.276 -0.384 -0.384
## 173 platelets_m3 ~ platelets_m1 2.830 -0.491 -0.491 -0.491 -0.491
## 174 albumin_m1 ~~ max_hct_m3 2.814 -0.083 -0.083 -0.105 -0.105
## 175 wbc_m1 ~~ alt_m3 2.813 0.070 0.070 0.105 0.105
## 176 wbc_m1 ~ max_hct_m1 2.808 -0.071 -0.071 -0.071 -0.071
## 177 alt_m3 ~ alt_m1 2.752 -1.337 -1.337 -1.337 -1.337
## 178 alt_m1 ~~ alt_m3 2.752 -0.788 -0.788 -1.034 -1.034
## 179 alt_m1 ~ age_t 2.752 0.080 0.080 0.080 0.080
## 180 lymph_m3 ~ max_hct_m1 2.735 -0.099 -0.099 -0.099 -0.099
## 181 tourn_no_m1 ~ albumin_m1 2.635 -0.086 -0.086 -0.086 -0.086
## 182 albumin_m3 ~ wbc_m1 2.600 -0.100 -0.100 -0.100 -0.100
## 183 max_hct_m1 ~~ lymph_m3 2.594 -0.076 -0.076 -0.100 -0.100
## 184 platelets_m3 ~ max_hct_m3 2.590 -0.103 -0.103 -0.103 -0.103
## 185 max_hct_m3 ~ platelets_m3 2.590 -0.098 -0.098 -0.098 -0.098
## 186 max_hct_m3 ~~ platelets_m3 2.590 -0.090 -0.090 -0.100 -0.100
## 187 ast_m1 ~ lymph_m3 2.580 -0.079 -0.079 -0.079 -0.079
## 188 lymph_m3 ~ albumin_m3 2.572 -0.094 -0.094 -0.094 -0.094
## 189 platelets_m1 ~~ alt_m3 2.550 -0.074 -0.074 -0.100 -0.100
## 190 max_hct_m3 ~ alt_m1 2.532 0.093 0.093 0.093 0.093
## 191 albumin_m1 ~ tourn_no_m1 2.526 -0.084 -0.084 -0.084 -0.084
## 192 platelets_m3 ~ lymph_m1 2.488 -0.096 -0.096 -0.096 -0.096
## 193 tourn_no_m3 ~ albumin_m1 2.459 -0.097 -0.097 -0.097 -0.097
## 194 wbc_m1 ~~ max_hct_m1 2.421 -0.053 -0.053 -0.097 -0.097
## 195 tourn_no_m1 ~ albumin_m3 2.399 -0.082 -0.082 -0.082 -0.082
## 196 tourn_no_m1 ~ max_hct_m3 2.390 0.082 0.082 0.082 0.082
## 197 max_hct_m3 ~ lymph_m1 2.347 -0.091 -0.091 -0.091 -0.091
## 198 albumin_m1 ~~ tourn_no_m3 2.339 -0.080 -0.080 -0.095 -0.095
## 199 age_t ~ max_hct_m3 2.315 -1.391 -1.391 -1.391 -1.391
## 200 dhf ~~ platelets_m1 2.271 -0.095 -0.095 -0.143 -0.143
## 201 dhf ~ platelets_m3 2.271 0.111 0.111 0.116 0.116
## 202 albumin_m1 ~ max_hct_m3 2.252 -0.079 -0.079 -0.079 -0.079
## 203 lymph_m3 ~ ast_m3 2.233 0.088 0.088 0.088 0.088
## 204 albumin_m1 ~ tourn_no_m3 2.230 -0.079 -0.079 -0.079 -0.079
## 205 dhf ~ albumin_m3 2.219 0.098 0.098 0.102 0.102
## 206 dhf ~~ albumin_m1 2.219 -0.132 -0.132 -0.176 -0.176
## 207 ast_m1 ~ albumin_m1 2.155 0.073 0.073 0.073 0.073
## 208 alt_m1 ~ wbc_m1 2.083 -0.069 -0.069 -0.069 -0.069
## 209 max_hct_m3 ~ alt_m3 2.066 0.085 0.085 0.085 0.085
## 210 alt_m3 ~~ max_hct_m3 2.066 0.084 0.084 0.090 0.090
## 211 alt_m3 ~ max_hct_m3 2.066 0.095 0.095 0.095 0.095
## 212 age_t ~ dhf 2.038 0.101 0.101 0.097 0.097
## 213 lymph_m1 ~~ max_hct_m3 2.026 -0.075 -0.075 -0.089 -0.089
## 214 lymph_m1 ~ dhf 2.020 -0.158 -0.158 -0.152 -0.152
## 215 dhf ~~ tourn_no_m3 1.945 0.089 0.089 0.102 0.102
## 216 albumin_m3 ~ alt_m1 1.941 -0.085 -0.085 -0.085 -0.085
## 217 alt_m1 ~ max_hct_m3 1.926 0.067 0.067 0.067 0.067
## 218 wbc_m1 ~ ast_m1 1.893 0.058 0.058 0.058 0.058
## 219 ast_m1 ~ wbc_m1 1.882 -0.068 -0.068 -0.068 -0.068
## 220 albumin_m3 ~ lymph_m3 1.818 -0.088 -0.088 -0.088 -0.088
## 221 dhf ~~ platelets_m3 1.794 0.092 0.092 0.108 0.108
## 222 ast_m1 ~~ lymph_m3 1.775 -0.062 -0.062 -0.083 -0.083
## 223 wbc_m1 ~ alt_m3 1.759 0.056 0.056 0.056 0.056
## 224 dhf ~ tourn_no_m3 1.748 0.086 0.086 0.090 0.090
## 225 dhf ~~ tourn_no_m1 1.748 -0.118 -0.118 -0.157 -0.157
## 226 wbc_m1 ~ platelets_m3 1.711 0.055 0.055 0.055 0.055
## 227 wbc_m1 ~ alt_m1 1.627 0.054 0.054 0.054 0.054
## 228 alt_m1 ~~ platelets_m1 1.570 -0.045 -0.045 -0.078 -0.078
## 229 wbc_m1 ~ lymph_m1 1.566 -0.053 -0.053 -0.053 -0.053
## 230 max_hct_m3 ~ ast_m1 1.536 0.073 0.073 0.073 0.073
## 231 max_hct_m1 ~~ platelets_m3 1.486 -0.059 -0.059 -0.076 -0.076
## 232 ast_m3 ~ lymph_m3 1.478 0.079 0.079 0.079 0.079
## 233 wbc_m3 ~ albumin_m1 1.460 0.074 0.074 0.074 0.074
## 234 ast_m1 ~~ wbc_m1 1.414 -0.040 -0.040 -0.074 -0.074
## 235 lymph_m1 ~ tourn_no_m3 1.394 -0.067 -0.067 -0.067 -0.067
## 236 albumin_m3 ~ tourn_no_m1 1.368 -0.072 -0.072 -0.072 -0.072
## 237 max_hct_m1 ~ albumin_m3 1.286 -0.058 -0.058 -0.058 -0.058
## 238 max_hct_m3 ~ dhf 1.273 -0.083 -0.083 -0.079 -0.079
## 239 alt_m1 ~ tourn_no_m3 1.254 0.054 0.054 0.054 0.054
## 240 tourn_no_m1 ~~ lymph_m3 1.253 -0.056 -0.056 -0.070 -0.070
## 241 max_hct_m3 ~ platelets_m1 1.241 -0.066 -0.066 -0.066 -0.066
## 242 ast_m1 ~~ tourn_no_m1 1.241 0.047 0.047 0.069 0.069
## 243 tourn_no_m3 ~ ast_m1 1.235 0.069 0.069 0.069 0.069
## 244 alt_m1 ~~ albumin_m1 1.214 0.045 0.045 0.069 0.069
## 245 age_t ~ tourn_no_m3 1.214 0.953 0.953 0.953 0.953
## 246 age_t ~ ast_m1 1.167 0.085 0.085 0.085 0.085
## 247 wbc_m3 ~ albumin_m3 1.154 0.066 0.066 0.066 0.066
## 248 dhf ~~ wbc_m3 1.144 -0.084 -0.084 -0.097 -0.097
## 249 tourn_no_m3 ~ alt_m1 1.134 0.066 0.066 0.066 0.066
## 250 ast_m1 ~ dhf 1.107 0.080 0.080 0.077 0.077
## 251 ast_m1 ~ age_t 1.064 0.051 0.051 0.051 0.051
## 252 dhf ~ ast_m3 0.992 0.070 0.070 0.073 0.073
## 253 dhf ~~ ast_m1 0.992 -0.071 -0.071 -0.102 -0.102
## 254 wbc_m1 ~~ tourn_no_m3 0.976 0.041 0.041 0.062 0.062
## 255 max_hct_m3 ~ tourn_no_m3 0.910 0.056 0.056 0.056 0.056
## 256 max_hct_m3 ~~ tourn_no_m3 0.910 0.055 0.055 0.060 0.060
## 257 tourn_no_m3 ~ max_hct_m3 0.910 0.063 0.063 0.063 0.063
## 258 max_hct_m1 ~~ wbc_m3 0.905 -0.047 -0.047 -0.059 -0.059
## 259 lymph_m1 ~~ tourn_no_m3 0.895 -0.053 -0.053 -0.059 -0.059
## 260 albumin_m1 ~~ tourn_no_m1 0.894 -0.042 -0.042 -0.059 -0.059
## 261 ast_m1 ~ tourn_no_m1 0.891 0.047 0.047 0.047 0.047
## 262 dhf ~ wbc_m3 0.876 -0.076 -0.076 -0.080 -0.080
## 263 dhf ~~ wbc_m1 0.876 0.048 0.048 0.079 0.079
## 264 alt_m1 ~~ tourn_no_m3 0.875 0.044 0.044 0.058 0.058
## 265 alt_m1 ~~ max_hct_m1 0.833 -0.036 -0.036 -0.057 -0.057
## 266 wbc_m3 ~ max_hct_m1 0.832 -0.057 -0.057 -0.057 -0.057
## 267 lymph_m1 ~~ platelets_m1 0.826 -0.039 -0.039 -0.057 -0.057
## 268 max_hct_m3 ~ tourn_no_m1 0.824 0.053 0.053 0.053 0.053
## 269 albumin_m3 ~ dhf 0.794 0.066 0.066 0.063 0.063
## 270 lymph_m3 ~ dhf 0.787 0.059 0.059 0.056 0.056
## 271 alt_m1 ~~ max_hct_m3 0.768 0.039 0.039 0.055 0.055
## 272 max_hct_m1 ~~ tourn_no_m3 0.727 -0.043 -0.043 -0.053 -0.053
## 273 albumin_m3 ~ platelets_m1 0.723 0.053 0.053 0.053 0.053
## 274 platelets_m1 ~ lymph_m1 0.722 -0.040 -0.040 -0.040 -0.040
## 275 platelets_m3 ~~ tourn_no_m3 0.668 -0.049 -0.049 -0.051 -0.051
## 276 platelets_m3 ~ tourn_no_m3 0.668 -0.049 -0.049 -0.049 -0.049
## 277 tourn_no_m3 ~ platelets_m3 0.668 -0.053 -0.053 -0.053 -0.053
## 278 ast_m1 ~~ platelets_m1 0.653 -0.030 -0.030 -0.050 -0.050
## 279 albumin_m3 ~ ast_m1 0.646 -0.062 -0.062 -0.062 -0.062
## 280 lymph_m1 ~ albumin_m3 0.634 0.045 0.045 0.045 0.045
## 281 lymph_m1 ~~ max_hct_m1 0.604 0.036 0.036 0.048 0.048
## 282 lymph_m1 ~ albumin_m1 0.599 0.044 0.044 0.044 0.044
## 283 ast_m1 ~ wbc_m3 0.592 -0.038 -0.038 -0.038 -0.038
## 284 ast_m1 ~~ max_hct_m1 0.581 -0.031 -0.031 -0.048 -0.048
## 285 alt_m3 ~ max_hct_m1 0.581 0.048 0.048 0.048 0.048
## 286 albumin_m1 ~~ wbc_m3 0.568 0.039 0.039 0.047 0.047
## 287 wbc_m1 ~~ tourn_no_m1 0.565 -0.027 -0.027 -0.047 -0.047
## 288 ast_m1 ~ albumin_m3 0.543 -0.037 -0.037 -0.037 -0.037
## 289 lymph_m1 ~ alt_m1 0.542 -0.042 -0.042 -0.042 -0.042
## 290 dhf ~ lymph_m3 0.497 0.043 0.043 0.045 0.045
## 291 dhf ~~ lymph_m1 0.497 -0.084 -0.084 -0.105 -0.105
## 292 wbc_m1 ~ max_hct_m3 0.496 -0.030 -0.030 -0.030 -0.030
## 293 albumin_m1 ~ wbc_m3 0.488 0.037 0.037 0.037 0.037
## 294 platelets_m1 ~ albumin_m3 0.463 -0.032 -0.032 -0.032 -0.032
## 295 lymph_m3 ~ alt_m1 0.451 0.039 0.039 0.039 0.039
## 296 lymph_m3 ~ albumin_m1 0.437 -0.039 -0.039 -0.039 -0.039
## 297 platelets_m1 ~~ lymph_m3 0.430 -0.029 -0.029 -0.041 -0.041
## 298 platelets_m1 ~ max_hct_m3 0.420 -0.031 -0.031 -0.031 -0.031
## 299 ast_m3 ~ ast_m1 0.359 -0.244 -0.244 -0.244 -0.244
## 300 albumin_m1 ~ wbc_m1 0.358 0.032 0.032 0.032 0.032
## 301 ast_m1 ~~ wbc_m3 0.346 -0.028 -0.028 -0.037 -0.037
## 302 wbc_m1 ~ tourn_no_m3 0.343 0.025 0.025 0.025 0.025
## 303 alt_m1 ~~ lymph_m3 0.343 0.026 0.026 0.037 0.037
## 304 albumin_m3 ~ alt_m3 0.334 -0.036 -0.036 -0.036 -0.036
## 305 albumin_m1 ~~ max_hct_m1 0.325 0.024 0.024 0.036 0.036
## 306 lymph_m3 ~~ max_hct_m3 0.323 -0.031 -0.031 -0.035 -0.035
## 307 lymph_m3 ~ max_hct_m3 0.323 -0.035 -0.035 -0.035 -0.035
## 308 max_hct_m3 ~ lymph_m3 0.323 -0.035 -0.035 -0.035 -0.035
## 309 lymph_m1 ~ max_hct_m1 0.313 -0.032 -0.032 -0.032 -0.032
## 310 alt_m1 ~~ wbc_m1 0.310 0.018 0.018 0.035 0.035
## 311 max_hct_m1 ~ lymph_m1 0.304 -0.028 -0.028 -0.028 -0.028
## 312 lymph_m1 ~ platelets_m1 0.303 -0.031 -0.031 -0.031 -0.031
## 313 lymph_m1 ~ ast_m3 0.298 -0.031 -0.031 -0.031 -0.031
## 314 dhf ~~ lymph_m3 0.292 0.030 0.030 0.037 0.037
## 315 alt_m3 ~~ tourn_no_m3 0.291 0.033 0.033 0.034 0.034
## 316 alt_m3 ~ tourn_no_m3 0.291 0.034 0.034 0.034 0.034
## 317 tourn_no_m3 ~ alt_m3 0.291 0.034 0.034 0.034 0.034
## 318 ast_m1 ~ max_hct_m3 0.290 0.027 0.027 0.027 0.027
## 319 dhf ~ age_t 0.277 -0.031 -0.031 -0.032 -0.032
## 320 alt_m1 ~~ lymph_m1 0.273 -0.023 -0.023 -0.033 -0.033
## 321 lymph_m1 ~ alt_m3 0.273 -0.030 -0.030 -0.030 -0.030
## 322 ast_m3 ~ max_hct_m1 0.266 -0.032 -0.032 -0.032 -0.032
## 323 tourn_no_m3 ~ albumin_m3 0.261 -0.032 -0.032 -0.032 -0.032
## 324 wbc_m1 ~~ max_hct_m3 0.245 0.020 0.020 0.031 0.031
## 325 alt_m1 ~ lymph_m1 0.233 -0.023 -0.023 -0.023 -0.023
## 326 tourn_no_m1 ~~ max_hct_m3 0.230 0.024 0.024 0.030 0.030
## 327 ast_m1 ~ lymph_m1 0.224 -0.023 -0.023 -0.023 -0.023
## 328 max_hct_m1 ~ alt_m1 0.209 -0.023 -0.023 -0.023 -0.023
## 329 albumin_m1 ~ lymph_m1 0.186 0.023 0.023 0.023 0.023
## 330 albumin_m3 ~ wbc_m3 0.185 0.027 0.027 0.027 0.027
## 331 alt_m3 ~ wbc_m1 0.174 -0.026 -0.026 -0.026 -0.026
## 332 lymph_m1 ~~ albumin_m1 0.172 0.020 0.020 0.026 0.026
## 333 albumin_m1 ~ max_hct_m1 0.167 -0.022 -0.022 -0.022 -0.022
## 334 wbc_m1 ~~ platelets_m3 0.148 0.016 0.016 0.024 0.024
## 335 max_hct_m1 ~ alt_m3 0.148 0.020 0.020 0.020 0.020
## 336 lymph_m1 ~~ platelets_m3 0.145 -0.021 -0.021 -0.024 -0.024
## 337 wbc_m1 ~ dhf 0.137 -0.021 -0.021 -0.020 -0.020
## 338 albumin_m1 ~ alt_m1 0.128 -0.019 -0.019 -0.019 -0.019
## 339 max_hct_m1 ~ tourn_no_m3 0.122 -0.018 -0.018 -0.018 -0.018
## 340 alt_m3 ~~ lymph_m3 0.119 0.020 0.020 0.022 0.022
## 341 lymph_m3 ~ alt_m3 0.119 0.020 0.020 0.020 0.020
## 342 alt_m3 ~ lymph_m3 0.119 0.023 0.023 0.023 0.023
## 343 wbc_m1 ~ tourn_no_m1 0.110 -0.014 -0.014 -0.014 -0.014
## 344 ast_m3 ~ wbc_m1 0.109 -0.020 -0.020 -0.020 -0.020
## 345 dhf ~~ alt_m3 0.100 0.022 0.022 0.026 0.026
## 346 lymph_m1 ~~ alt_m3 0.100 -0.018 -0.018 -0.020 -0.020
## 347 lymph_m3 ~ tourn_no_m1 0.097 0.018 0.018 0.018 0.018
## 348 ast_m1 ~ max_hct_m1 0.094 -0.015 -0.015 -0.015 -0.015
## 349 dhf ~ alt_m3 0.063 0.018 0.018 0.019 0.019
## 350 dhf ~~ alt_m1 0.063 -0.017 -0.017 -0.025 -0.025
## 351 albumin_m3 ~ lymph_m1 0.055 0.014 0.014 0.014 0.014
## 352 albumin_m1 ~ age_t 0.050 0.012 0.012 0.012 0.012
## 353 albumin_m1 ~~ lymph_m3 0.049 0.011 0.011 0.014 0.014
## 354 ast_m1 ~~ lymph_m1 0.048 0.010 0.010 0.014 0.014
## 355 max_hct_m3 ~ wbc_m3 0.048 -0.013 -0.013 -0.013 -0.013
## 356 wbc_m3 ~~ max_hct_m3 0.048 -0.013 -0.013 -0.014 -0.014
## 357 wbc_m3 ~ max_hct_m3 0.048 -0.014 -0.014 -0.014 -0.014
## 358 lymph_m1 ~ platelets_m3 0.041 0.012 0.012 0.012 0.012
## 359 ast_m1 ~~ max_hct_m3 0.039 0.009 0.009 0.012 0.012
## 360 max_hct_m3 ~ wbc_m1 0.032 0.011 0.011 0.011 0.011
## 361 tourn_no_m3 ~ max_hct_m1 0.031 -0.011 -0.011 -0.011 -0.011
## 362 max_hct_m3 ~ albumin_m1 0.028 -0.010 -0.010 -0.010 -0.010
## 363 age_t ~ albumin_m1 0.026 0.012 0.012 0.012 0.012
## 364 lymph_m1 ~ ast_m1 0.025 -0.009 -0.009 -0.009 -0.009
## 365 alt_m3 ~ lymph_m1 0.023 -0.010 -0.010 -0.010 -0.010
## 366 alt_m1 ~ albumin_m1 0.022 -0.007 -0.007 -0.007 -0.007
## 367 albumin_m3 ~ tourn_no_m3 0.020 -0.009 -0.009 -0.009 -0.009
## 368 lymph_m3 ~ ast_m1 0.020 -0.008 -0.008 -0.008 -0.008
## 369 albumin_m1 ~ lymph_m3 0.017 0.007 0.007 0.007 0.007
## 370 ast_m1 ~~ tourn_no_m3 0.016 -0.006 -0.006 -0.008 -0.008
## 371 wbc_m1 ~~ albumin_m1 0.016 0.004 0.004 0.008 0.008
## 372 max_hct_m1 ~ albumin_m1 0.014 -0.006 -0.006 -0.006 -0.006
## 373 platelets_m1 ~~ max_hct_m3 0.010 -0.004 -0.004 -0.006 -0.006
## 374 tourn_no_m3 ~ lymph_m1 0.009 0.006 0.006 0.006 0.006
## 375 albumin_m1 ~ ast_m1 0.006 0.004 0.004 0.004 0.004
## 376 ast_m3 ~ lymph_m1 0.005 0.004 0.004 0.004 0.004
## 377 alt_m1 ~ max_hct_m1 0.004 0.003 0.003 0.003 0.003
## 378 platelets_m1 ~ lymph_m3 0.003 -0.003 -0.003 -0.003 -0.003
## 379 max_hct_m1 ~~ alt_m3 0.002 -0.002 -0.002 -0.003 -0.003
## 380 albumin_m3 ~ max_hct_m1 0.001 0.002 0.002 0.002 0.002
## 381 alt_m1 ~ lymph_m3 0.000 -0.001 -0.001 -0.001 -0.001
## 382 platelets_m3 ~ dhf 0.000 0.001 0.001 0.001 0.001
## 383 ast_m1 ~ tourn_no_m3 0.000 0.000 0.000 0.000 0.000
Note the indication to add an association among AST and ALT measures at time 1 and time 3, pointing the following alternatives:
-
alt_m3 ~ ast_m3 (ast_m3 as having effect on alt_m3);
-
ast_m3 ~ alt_m3 (alt_m3 as having effect on ast_m3);
-
alt_m1 ~ ast_m1 (ast_m1 as having effect on alt_m1);
-
ast_m1 ~ alt_m1 (alt_m1 as having effect on ast_m1);
which does not make sense theoretically. But the following one makes sense:
- ast_m1 ~~ alt_m1 (covariance among two enzyme levels)
Both are enzymes which are well known to be increased when hepatotoxicity or liver inflammatory process is involved. Covariances are expected among variables with a common cause, like AST and ALT. And we can add such a relationship for both times -3 and -1 day.
And possibly considering the evolution in time, it is also reasonable to consider the effect of AST at time day -3 on the ALT at time -1, but not the following:
- alt_m3 ~ ast_m1
But note the covariance or correlation measures assess association without no directionality. So, considering the relationship between ALT and AST is reasonable, apparently, such an effect exists, just the algorithm is not able to identify the directionality.
Adjusted model
library(lavaan)
model="
dhf~ast_m1+alt_m1+wbc_m1+lymph_m1+albumin_m1+max_hct_m1+platelets_m1+tourn_no_m1
ast_m1~ast_m3 + alt_m3
alt_m1~alt_m3 + ast_m3
wbc_m1~wbc_m3
lymph_m1~lymph_m3
albumin_m1~albumin_m3
max_hct_m1~max_hct_m3
platelets_m1~platelets_m3
tourn_no_m1~tourn_no_m3
alt_m3~age_t
wbc_m3~age_t
lymph_m3~age_t
max_hct_m3~age_t
platelets_m3~age_t
tourn_no_m3~age_t
ast_m1~~alt_m1
ast_m3~~alt_m3
"
fit=sem(model=model, data=data,std.ov=TRUE,estimator="MLR",fixed.x = FALSE)
fitmeasures(fit)[c('cfi.robust','tli.robust','rmsea.robust','rmsea.ci.lower.robust' , 'rmsea.ci.upper.robust')]
## cfi.robust tli.robust rmsea.robust
## 0.79909545 0.75763895 0.10551648
## rmsea.ci.lower.robust rmsea.ci.upper.robust
## 0.09572743 0.11548461
Look how it improved. But still not sufficient.
parameterestimates(fit,standardized = TRUE)
## lhs op rhs est se z pvalue ci.lower ci.upper
## 1 dhf ~ ast_m1 0.076 0.112 0.674 0.500 -0.144 0.295
## 2 dhf ~ alt_m1 0.082 0.104 0.784 0.433 -0.122 0.285
## 3 dhf ~ wbc_m1 0.006 0.057 0.101 0.920 -0.107 0.118
## 4 dhf ~ lymph_m1 -0.082 0.058 -1.411 0.158 -0.195 0.032
## 5 dhf ~ albumin_m1 0.022 0.059 0.379 0.704 -0.093 0.138
## 6 dhf ~ max_hct_m1 0.186 0.058 3.224 0.001 0.073 0.299
## 7 dhf ~ platelets_m1 -0.215 0.064 -3.358 0.001 -0.341 -0.090
## 8 dhf ~ tourn_no_m1 0.156 0.058 2.665 0.008 0.041 0.270
## 9 ast_m1 ~ ast_m3 0.802 0.117 6.856 0.000 0.573 1.031
## 10 ast_m1 ~ alt_m3 -0.258 0.064 -4.022 0.000 -0.383 -0.132
## 11 alt_m1 ~ alt_m3 0.282 0.162 1.741 0.082 -0.035 0.600
## 12 alt_m1 ~ ast_m3 0.481 0.090 5.351 0.000 0.305 0.657
## 13 wbc_m1 ~ wbc_m3 0.735 0.051 14.423 0.000 0.635 0.835
## 14 lymph_m1 ~ lymph_m3 0.419 0.058 7.265 0.000 0.306 0.532
## 15 albumin_m1 ~ albumin_m3 0.531 0.056 9.456 0.000 0.421 0.641
## 16 max_hct_m1 ~ max_hct_m3 0.581 0.073 7.953 0.000 0.438 0.725
## 17 platelets_m1 ~ platelets_m3 0.660 0.056 11.762 0.000 0.550 0.770
## 18 tourn_no_m1 ~ tourn_no_m3 0.526 0.051 10.302 0.000 0.426 0.626
## 19 alt_m3 ~ age_t 0.127 0.040 3.135 0.002 0.048 0.206
## 20 wbc_m3 ~ age_t -0.186 0.053 -3.523 0.000 -0.289 -0.082
## 21 lymph_m3 ~ age_t -0.345 0.061 -5.639 0.000 -0.464 -0.225
## 22 max_hct_m3 ~ age_t 0.341 0.061 5.618 0.000 0.222 0.460
## 23 platelets_m3 ~ age_t -0.274 0.062 -4.422 0.000 -0.395 -0.152
## 24 tourn_no_m3 ~ age_t 0.116 0.062 1.866 0.062 -0.006 0.237
## 25 ast_m1 ~~ alt_m1 0.385 0.193 1.998 0.046 0.007 0.763
## 26 alt_m3 ~~ ast_m3 0.743 0.274 2.710 0.007 0.206 1.281
## 27 dhf ~~ dhf 0.781 0.075 10.464 0.000 0.635 0.927
## 28 ast_m1 ~~ ast_m1 0.595 0.404 1.473 0.141 -0.196 1.386
## 29 alt_m1 ~~ alt_m1 0.486 0.153 3.183 0.001 0.187 0.785
## 30 wbc_m1 ~~ wbc_m1 0.458 0.061 7.460 0.000 0.338 0.578
## 31 lymph_m1 ~~ lymph_m1 0.821 0.082 10.067 0.000 0.661 0.981
## 32 albumin_m1 ~~ albumin_m1 0.716 0.091 7.905 0.000 0.538 0.893
## 33 max_hct_m1 ~~ max_hct_m1 0.659 0.082 7.998 0.000 0.498 0.821
## 34 platelets_m1 ~~ platelets_m1 0.562 0.052 10.910 0.000 0.461 0.663
## 35 tourn_no_m1 ~~ tourn_no_m1 0.721 0.055 13.124 0.000 0.613 0.828
## 36 alt_m3 ~~ alt_m3 0.987 0.408 2.417 0.016 0.187 1.787
## 37 wbc_m3 ~~ wbc_m3 0.962 0.248 3.882 0.000 0.476 1.447
## 38 lymph_m3 ~~ lymph_m3 0.878 0.083 10.547 0.000 0.715 1.041
## 39 max_hct_m3 ~~ max_hct_m3 0.880 0.099 8.869 0.000 0.686 1.075
## 40 platelets_m3 ~~ platelets_m3 0.922 0.091 10.103 0.000 0.743 1.100
## 41 tourn_no_m3 ~~ tourn_no_m3 0.983 0.060 16.407 0.000 0.865 1.100
## 42 ast_m3 ~~ ast_m3 0.996 0.428 2.329 0.020 0.158 1.834
## 43 albumin_m3 ~~ albumin_m3 0.996 0.102 9.727 0.000 0.795 1.197
## 44 albumin_m3 ~~ age_t 0.068 0.060 1.136 0.256 -0.050 0.186
## 45 age_t ~~ age_t 0.996 0.068 14.642 0.000 0.863 1.129
## std.lv std.all std.nox
## 1 0.076 0.079 0.079
## 2 0.082 0.085 0.085
## 3 0.006 0.006 0.006
## 4 -0.082 -0.085 -0.085
## 5 0.022 0.023 0.023
## 6 0.186 0.193 0.193
## 7 -0.215 -0.224 -0.224
## 8 0.156 0.162 0.162
## 9 0.802 0.803 0.803
## 10 -0.258 -0.259 -0.259
## 11 0.282 0.283 0.283
## 12 0.481 0.480 0.480
## 13 0.735 0.735 0.735
## 14 0.419 0.419 0.419
## 15 0.531 0.531 0.532
## 16 0.581 0.581 0.581
## 17 0.660 0.660 0.660
## 18 0.526 0.526 0.526
## 19 0.127 0.126 0.127
## 20 -0.186 -0.186 -0.186
## 21 -0.345 -0.345 -0.345
## 22 0.341 0.341 0.342
## 23 -0.274 -0.274 -0.274
## 24 0.116 0.116 0.116
## 25 0.385 0.716 0.716
## 26 0.743 0.750 0.750
## 27 0.781 0.848 0.848
## 28 0.595 0.598 0.598
## 29 0.486 0.487 0.487
## 30 0.458 0.460 0.460
## 31 0.821 0.824 0.824
## 32 0.716 0.718 0.718
## 33 0.659 0.662 0.662
## 34 0.562 0.565 0.565
## 35 0.721 0.724 0.724
## 36 0.987 0.984 0.984
## 37 0.962 0.965 0.965
## 38 0.878 0.881 0.881
## 39 0.880 0.883 0.883
## 40 0.922 0.925 0.925
## 41 0.983 0.987 0.987
## 42 0.996 1.000 1.000
## 43 0.996 1.000 0.996
## 44 0.068 0.069 0.068
## 45 0.996 1.000 0.996
And that’s because other relationships, as indicated further by modification indices:
modificationindices(fit,standardized = TRUE)%>%arrange(-mi)
## lhs op rhs mi epc sepc.lv sepc.all sepc.nox
## 1 wbc_m3 ~ platelets_m1 49.241 0.437 0.437 0.437 0.437
## 2 wbc_m3 ~ lymph_m3 47.503 -0.450 -0.450 -0.450 -0.450
## 3 lymph_m3 ~ wbc_m3 47.503 -0.411 -0.411 -0.411 -0.411
## 4 wbc_m3 ~~ lymph_m3 47.503 -0.395 -0.395 -0.430 -0.430
## 5 platelets_m1 ~ wbc_m1 37.130 0.286 0.286 0.286 0.286
## 6 wbc_m3 ~~ platelets_m3 29.204 0.317 0.317 0.337 0.337
## 7 wbc_m3 ~ platelets_m3 29.204 0.344 0.344 0.344 0.344
## 8 platelets_m3 ~ wbc_m3 29.204 0.330 0.330 0.330 0.330
## 9 wbc_m3 ~ lymph_m1 24.912 -0.309 -0.309 -0.309 -0.309
## 10 platelets_m1 ~ wbc_m3 23.496 0.227 0.227 0.227 0.227
## 11 platelets_m1 ~~ wbc_m3 21.352 0.212 0.212 0.288 0.288
## 12 max_hct_m3 ~ max_hct_m1 21.000 -0.967 -0.967 -0.967 -0.967
## 13 max_hct_m1 ~~ max_hct_m3 21.000 -0.638 -0.638 -0.837 -0.837
## 14 max_hct_m1 ~ age_t 21.000 0.247 0.247 0.247 0.248
## 15 age_t ~ max_hct_m1 20.732 0.370 0.370 0.370 0.370
## 16 albumin_m1 ~ platelets_m1 19.527 0.234 0.234 0.234 0.234
## 17 platelets_m3 ~ wbc_m1 17.671 0.255 0.255 0.255 0.255
## 18 max_hct_m1 ~ platelets_m1 16.870 -0.209 -0.209 -0.209 -0.209
## 19 wbc_m3 ~ dhf 15.966 -0.344 -0.344 -0.331 -0.331
## 20 platelets_m3 ~ ast_m1 15.138 -0.234 -0.234 -0.234 -0.234
## 21 wbc_m1 ~ lymph_m3 14.663 0.162 0.162 0.162 0.162
## 22 albumin_m1 ~~ platelets_m1 14.651 0.151 0.151 0.239 0.239
## 23 wbc_m1 ~ ast_m3 14.392 0.160 0.160 0.160 0.160
## 24 tourn_no_m1 ~ max_hct_m1 14.196 0.200 0.200 0.200 0.200
## 25 wbc_m1 ~~ platelets_m1 13.932 0.118 0.118 0.233 0.233
## 26 wbc_m1 ~~ ast_m3 13.908 0.104 0.104 0.154 0.154
## 27 platelets_m3 ~ albumin_m1 13.740 0.223 0.223 0.223 0.223
## 28 wbc_m1 ~ albumin_m3 13.526 -0.156 -0.156 -0.156 -0.156
## 29 wbc_m1 ~ platelets_m1 13.460 0.155 0.155 0.155 0.155
## 30 max_hct_m1 ~ dhf 13.454 0.308 0.308 0.297 0.297
## 31 lymph_m1 ~ wbc_m1 13.118 -0.205 -0.205 -0.205 -0.205
## 32 max_hct_m1 ~~ tourn_no_m1 12.430 0.152 0.152 0.220 0.220
## 33 wbc_m3 ~ ast_m3 12.157 -0.214 -0.214 -0.214 -0.214
## 34 wbc_m1 ~ age_t 12.133 -0.150 -0.150 -0.150 -0.150
## 35 wbc_m1 ~~ wbc_m3 12.133 -0.776 -0.776 -1.169 -1.169
## 36 wbc_m3 ~ wbc_m1 12.133 -1.695 -1.695 -1.695 -1.695
## 37 albumin_m3 ~ alt_m1 11.898 -0.215 -0.215 -0.215 -0.215
## 38 platelets_m3 ~ ast_m3 11.830 -0.206 -0.206 -0.206 -0.206
## 39 platelets_m3 ~ alt_m1 11.674 -0.205 -0.205 -0.205 -0.205
## 40 tourn_no_m1 ~ platelets_m1 11.529 -0.180 -0.180 -0.180 -0.180
## 41 max_hct_m1 ~~ platelets_m1 11.503 -0.129 -0.129 -0.212 -0.212
## 42 albumin_m1 ~ dhf 11.389 -0.297 -0.297 -0.286 -0.286
## 43 age_t ~ tourn_no_m1 11.297 0.247 0.247 0.247 0.247
## 44 wbc_m3 ~~ tourn_no_m3 11.169 -0.203 -0.203 -0.208 -0.208
## 45 wbc_m3 ~ tourn_no_m3 11.169 -0.206 -0.206 -0.206 -0.206
## 46 tourn_no_m3 ~ wbc_m3 11.169 -0.211 -0.211 -0.211 -0.211
## 47 wbc_m3 ~ tourn_no_m1 10.973 -0.203 -0.203 -0.203 -0.203
## 48 age_t ~ wbc_m1 10.921 -0.308 -0.308 -0.308 -0.308
## 49 tourn_no_m3 ~ tourn_no_m1 10.418 -2.035 -2.035 -2.035 -2.035
## 50 tourn_no_m1 ~~ tourn_no_m3 10.418 -1.467 -1.467 -1.743 -1.743
## 51 tourn_no_m1 ~ age_t 10.418 0.172 0.172 0.172 0.173
## 52 platelets_m3 ~~ ast_m3 10.166 -0.126 -0.126 -0.132 -0.132
## 53 tourn_no_m1 ~ alt_m1 9.970 0.167 0.167 0.168 0.168
## 54 platelets_m1 ~ dhf 9.950 -0.226 -0.226 -0.217 -0.217
## 55 wbc_m1 ~~ lymph_m1 9.873 -0.120 -0.120 -0.196 -0.196
## 56 platelets_m1 ~ max_hct_m1 9.856 -0.147 -0.147 -0.147 -0.147
## 57 lymph_m3 ~ wbc_m1 9.605 -0.183 -0.183 -0.183 -0.183
## 58 alt_m3 ~ alt_m1 9.529 -0.961 -0.961 -0.959 -0.959
## 59 lymph_m3 ~~ platelets_m3 9.526 -0.173 -0.173 -0.193 -0.193
## 60 lymph_m3 ~ platelets_m3 9.526 -0.188 -0.188 -0.188 -0.188
## 61 platelets_m3 ~ lymph_m3 9.526 -0.197 -0.197 -0.197 -0.197
## 62 platelets_m1 ~ tourn_no_m1 9.426 -0.144 -0.144 -0.144 -0.144
## 63 wbc_m3 ~ alt_m1 9.379 -0.188 -0.188 -0.188 -0.188
## 64 ast_m3 ~ platelets_m3 9.166 -0.128 -0.128 -0.128 -0.128
## 65 max_hct_m1 ~ lymph_m3 9.103 -0.154 -0.154 -0.154 -0.154
## 66 age_t ~ platelets_m3 9.025 -2.835 -2.835 -2.835 -2.835
## 67 albumin_m3 ~ platelets_m3 9.025 0.194 0.194 0.194 0.194
## 68 platelets_m3 ~ albumin_m3 9.025 0.181 0.181 0.181 0.181
## 69 albumin_m3 ~ ast_m3 8.962 -0.186 -0.186 -0.186 -0.186
## 70 tourn_no_m1 ~ lymph_m1 8.959 -0.159 -0.159 -0.159 -0.159
## 71 platelets_m1 ~ albumin_m1 8.316 0.135 0.135 0.135 0.135
## 72 ast_m3 ~ alt_m1 8.230 1.164 1.164 1.165 1.165
## 73 wbc_m3 ~~ ast_m3 8.052 -0.115 -0.115 -0.117 -0.117
## 74 max_hct_m1 ~ tourn_no_m1 7.929 0.143 0.143 0.143 0.143
## 75 wbc_m1 ~~ lymph_m3 7.921 0.111 0.111 0.176 0.176
## 76 albumin_m3 ~ alt_m3 7.908 -0.176 -0.176 -0.176 -0.176
## 77 max_hct_m1 ~~ ast_m3 7.907 -0.094 -0.094 -0.116 -0.116
## 78 ast_m3 ~ wbc_m3 7.533 -0.114 -0.114 -0.114 -0.114
## 79 albumin_m1 ~ ast_m3 7.243 -0.142 -0.142 -0.142 -0.142
## 80 tourn_no_m1 ~ ast_m3 6.852 0.139 0.139 0.139 0.139
## 81 alt_m1 ~~ alt_m3 6.822 -0.276 -0.276 -0.398 -0.398
## 82 alt_m1 ~ age_t 6.822 0.081 0.081 0.081 0.081
## 83 alt_m1 ~~ ast_m3 6.822 0.370 0.370 0.531 0.531
## 84 ast_m3 ~ platelets_m1 6.753 -0.108 -0.108 -0.108 -0.108
## 85 wbc_m3 ~ ast_m1 6.753 -0.159 -0.159 -0.159 -0.159
## 86 lymph_m1 ~ tourn_no_m1 6.647 -0.146 -0.146 -0.146 -0.146
## 87 tourn_no_m1 ~ alt_m3 6.600 0.136 0.136 0.136 0.136
## 88 tourn_no_m1 ~ platelets_m3 6.428 -0.135 -0.135 -0.135 -0.135
## 89 tourn_no_m1 ~ dhf 6.403 0.233 0.233 0.224 0.224
## 90 albumin_m1 ~~ platelets_m3 6.220 0.126 0.126 0.156 0.156
## 91 lymph_m3 ~ platelets_m1 6.212 -0.148 -0.148 -0.148 -0.148
## 92 ast_m3 ~ tourn_no_m1 6.195 0.103 0.103 0.103 0.103
## 93 tourn_no_m1 ~ ast_m1 6.165 0.132 0.132 0.132 0.132
## 94 albumin_m3 ~ ast_m1 6.063 -0.153 -0.153 -0.153 -0.153
## 95 lymph_m1 ~~ wbc_m3 6.015 -0.136 -0.136 -0.153 -0.153
## 96 lymph_m3 ~~ tourn_no_m3 5.843 0.140 0.140 0.151 0.151
## 97 lymph_m3 ~ tourn_no_m3 5.843 0.143 0.143 0.143 0.143
## 98 tourn_no_m3 ~ lymph_m3 5.843 0.160 0.160 0.160 0.160
## 99 tourn_no_m1 ~ wbc_m3 5.758 -0.127 -0.127 -0.127 -0.127
## 100 tourn_no_m3 ~~ ast_m3 5.698 0.098 0.098 0.099 0.099
## 101 age_t ~ max_hct_m3 5.622 -2.289 -2.289 -2.289 -2.289
## 102 max_hct_m3 ~ albumin_m3 5.622 0.139 0.139 0.139 0.140
## 103 albumin_m3 ~ max_hct_m3 5.622 0.157 0.157 0.157 0.157
## 104 max_hct_m1 ~ platelets_m3 5.574 -0.120 -0.120 -0.120 -0.120
## 105 albumin_m1 ~ platelets_m3 5.467 0.124 0.124 0.124 0.124
## 106 ast_m3 ~ tourn_no_m3 5.457 0.097 0.097 0.097 0.097
## 107 max_hct_m1 ~ wbc_m1 5.443 -0.119 -0.119 -0.119 -0.119
## 108 ast_m3 ~ albumin_m1 5.390 -0.096 -0.096 -0.096 -0.096
## 109 lymph_m1 ~~ tourn_no_m1 5.295 -0.110 -0.110 -0.144 -0.144
## 110 platelets_m1 ~~ tourn_no_m1 5.255 -0.091 -0.091 -0.143 -0.143
## 111 tourn_no_m1 ~ wbc_m1 5.168 -0.121 -0.121 -0.121 -0.121
## 112 age_t ~ lymph_m1 4.953 -0.162 -0.162 -0.162 -0.162
## 113 lymph_m1 ~~ lymph_m3 4.905 -0.340 -0.340 -0.401 -0.401
## 114 lymph_m3 ~ lymph_m1 4.905 -0.415 -0.415 -0.415 -0.415
## 115 lymph_m1 ~ age_t 4.905 -0.134 -0.134 -0.134 -0.134
## 116 tourn_no_m1 ~ lymph_m3 4.653 -0.115 -0.115 -0.115 -0.115
## 117 wbc_m3 ~ alt_m3 4.605 -0.132 -0.132 -0.133 -0.133
## 118 platelets_m1 ~ tourn_no_m3 4.540 -0.100 -0.100 -0.100 -0.100
## 119 ast_m1 ~~ lymph_m3 4.444 -0.066 -0.066 -0.092 -0.092
## 120 platelets_m1 ~ alt_m1 4.330 -0.097 -0.097 -0.098 -0.098
## 121 lymph_m1 ~ max_hct_m3 4.251 -0.118 -0.118 -0.118 -0.118
## 122 lymph_m1 ~ wbc_m3 4.112 -0.115 -0.115 -0.115 -0.115
## 123 dhf ~ max_hct_m3 4.099 -0.138 -0.138 -0.143 -0.143
## 124 dhf ~~ max_hct_m1 4.099 0.156 0.156 0.218 0.218
## 125 tourn_no_m3 ~ platelets_m1 4.087 -0.127 -0.127 -0.127 -0.127
## 126 age_t ~ alt_m1 4.024 0.128 0.128 0.128 0.128
## 127 max_hct_m1 ~~ alt_m3 4.002 0.067 0.067 0.083 0.083
## 128 tourn_no_m3 ~ ast_m3 3.937 0.123 0.123 0.123 0.123
## 129 max_hct_m1 ~ ast_m3 3.931 -0.101 -0.101 -0.101 -0.101
## 130 platelets_m1 ~~ tourn_no_m3 3.825 -0.091 -0.091 -0.122 -0.122
## 131 ast_m3 ~ lymph_m3 3.793 0.083 0.083 0.083 0.083
## 132 platelets_m3 ~ max_hct_m1 3.645 -0.117 -0.117 -0.117 -0.117
## 133 platelets_m3 ~ tourn_no_m1 3.594 -0.114 -0.114 -0.114 -0.114
## 134 albumin_m1 ~~ ast_m3 3.558 -0.066 -0.066 -0.078 -0.078
## 135 albumin_m1 ~ alt_m3 3.539 -0.099 -0.099 -0.099 -0.099
## 136 dhf ~~ max_hct_m3 3.505 -0.116 -0.116 -0.140 -0.140
## 137 lymph_m3 ~~ ast_m3 3.479 0.072 0.072 0.077 0.077
## 138 wbc_m1 ~ albumin_m1 3.406 -0.078 -0.078 -0.078 -0.078
## 139 tourn_no_m3 ~ dhf 3.403 0.139 0.139 0.134 0.134
## 140 ast_m3 ~ ast_m1 3.395 0.682 0.682 0.682 0.682
## 141 tourn_no_m1 ~~ wbc_m3 3.368 -0.095 -0.095 -0.114 -0.114
## 142 max_hct_m1 ~ ast_m1 3.299 -0.092 -0.092 -0.092 -0.092
## 143 age_t ~ platelets_m1 3.294 -0.156 -0.156 -0.156 -0.156
## 144 ast_m3 ~ max_hct_m1 3.277 -0.076 -0.076 -0.076 -0.076
## 145 albumin_m3 ~ tourn_no_m1 3.162 -0.111 -0.111 -0.111 -0.111
## 146 platelets_m3 ~ alt_m3 3.144 -0.107 -0.107 -0.107 -0.107
## 147 max_hct_m3 ~ ast_m3 3.137 0.104 0.104 0.104 0.104
## 148 ast_m1 ~ lymph_m3 3.121 -0.060 -0.060 -0.060 -0.060
## 149 alt_m3 ~ ast_m1 3.115 -0.497 -0.497 -0.495 -0.495
## 150 tourn_no_m3 ~ wbc_m1 3.100 -0.110 -0.110 -0.110 -0.110
## 151 alt_m3 ~ max_hct_m1 3.072 0.073 0.073 0.073 0.073
## 152 platelets_m1 ~ alt_m3 3.049 -0.082 -0.082 -0.082 -0.082
## 153 max_hct_m1 ~ wbc_m3 3.023 -0.088 -0.088 -0.088 -0.088
## 154 tourn_no_m1 ~~ platelets_m3 2.968 -0.088 -0.088 -0.107 -0.107
## 155 platelets_m1 ~ ast_m3 2.924 -0.080 -0.080 -0.080 -0.080
## 156 platelets_m1 ~ ast_m1 2.842 -0.079 -0.079 -0.079 -0.079
## 157 ast_m3 ~ dhf 2.837 0.086 0.086 0.082 0.082
## 158 platelets_m3 ~ platelets_m1 2.830 -0.491 -0.491 -0.491 -0.491
## 159 platelets_m1 ~~ platelets_m3 2.830 -0.276 -0.276 -0.384 -0.384
## 160 platelets_m1 ~ age_t 2.830 -0.082 -0.082 -0.082 -0.082
## 161 albumin_m1 ~~ max_hct_m3 2.814 -0.083 -0.083 -0.105 -0.105
## 162 wbc_m1 ~ max_hct_m1 2.808 -0.071 -0.071 -0.071 -0.071
## 163 lymph_m3 ~ max_hct_m1 2.735 -0.099 -0.099 -0.099 -0.099
## 164 wbc_m1 ~~ alt_m3 2.642 -0.045 -0.045 -0.067 -0.067
## 165 tourn_no_m1 ~ albumin_m1 2.635 -0.086 -0.086 -0.086 -0.086
## 166 max_hct_m1 ~~ lymph_m3 2.594 -0.076 -0.076 -0.100 -0.100
## 167 max_hct_m3 ~~ platelets_m3 2.590 -0.090 -0.090 -0.100 -0.100
## 168 platelets_m3 ~ max_hct_m3 2.590 -0.103 -0.103 -0.103 -0.103
## 169 max_hct_m3 ~ platelets_m3 2.590 -0.098 -0.098 -0.098 -0.098
## 170 age_t ~ lymph_m3 2.572 1.550 1.550 1.550 1.550
## 171 lymph_m3 ~ albumin_m3 2.572 -0.094 -0.094 -0.094 -0.094
## 172 albumin_m3 ~ lymph_m3 2.572 -0.106 -0.106 -0.106 -0.106
## 173 alt_m1 ~ wbc_m3 2.565 -0.049 -0.049 -0.049 -0.049
## 174 albumin_m1 ~ tourn_no_m1 2.526 -0.084 -0.084 -0.084 -0.084
## 175 max_hct_m3 ~ alt_m1 2.520 0.093 0.093 0.093 0.093
## 176 albumin_m3 ~ wbc_m1 2.492 -0.099 -0.099 -0.099 -0.099
## 177 platelets_m3 ~ lymph_m1 2.488 -0.096 -0.096 -0.096 -0.096
## 178 tourn_no_m3 ~ albumin_m1 2.459 -0.097 -0.097 -0.097 -0.097
## 179 wbc_m1 ~~ max_hct_m1 2.421 -0.053 -0.053 -0.097 -0.097
## 180 tourn_no_m1 ~ albumin_m3 2.399 -0.082 -0.082 -0.082 -0.082
## 181 tourn_no_m1 ~ max_hct_m3 2.390 0.082 0.082 0.082 0.082
## 182 max_hct_m3 ~ lymph_m1 2.347 -0.091 -0.091 -0.091 -0.091
## 183 alt_m1 ~ max_hct_m1 2.343 0.047 0.047 0.047 0.047
## 184 albumin_m1 ~~ tourn_no_m3 2.339 -0.080 -0.080 -0.095 -0.095
## 185 dhf ~ platelets_m3 2.272 0.111 0.111 0.115 0.115
## 186 dhf ~~ platelets_m1 2.272 -0.095 -0.095 -0.143 -0.143
## 187 albumin_m3 ~ platelets_m1 2.258 0.095 0.095 0.095 0.095
## 188 albumin_m1 ~ max_hct_m3 2.252 -0.079 -0.079 -0.079 -0.079
## 189 albumin_m1 ~ tourn_no_m3 2.230 -0.079 -0.079 -0.079 -0.079
## 190 lymph_m3 ~ ast_m3 2.230 0.087 0.087 0.087 0.087
## 191 tourn_no_m1 ~~ ast_m3 2.204 0.052 0.052 0.061 0.061
## 192 dhf ~ albumin_m3 2.198 0.097 0.097 0.100 0.101
## 193 dhf ~~ albumin_m1 2.198 -0.130 -0.130 -0.174 -0.174
## 194 max_hct_m3 ~ alt_m3 2.065 0.085 0.085 0.085 0.085
## 195 alt_m3 ~~ tourn_no_m3 2.052 -0.058 -0.058 -0.059 -0.059
## 196 alt_m3 ~ tourn_no_m3 2.052 -0.059 -0.059 -0.059 -0.059
## 197 lymph_m1 ~~ max_hct_m3 2.026 -0.075 -0.075 -0.089 -0.089
## 198 age_t ~ dhf 1.994 0.099 0.099 0.095 0.095
## 199 lymph_m1 ~ dhf 1.950 -0.153 -0.153 -0.147 -0.147
## 200 dhf ~~ tourn_no_m3 1.945 0.089 0.089 0.102 0.102
## 201 wbc_m1 ~ ast_m1 1.896 0.058 0.058 0.058 0.058
## 202 alt_m1 ~~ lymph_m3 1.863 0.039 0.039 0.059 0.059
## 203 ast_m3 ~ albumin_m3 1.857 -0.056 -0.056 -0.056 -0.056
## 204 dhf ~~ platelets_m3 1.794 0.092 0.092 0.108 0.108
## 205 dhf ~~ tourn_no_m1 1.748 -0.118 -0.118 -0.157 -0.157
## 206 dhf ~ tourn_no_m3 1.748 0.086 0.086 0.089 0.089
## 207 wbc_m1 ~ alt_m3 1.748 0.056 0.056 0.056 0.056
## 208 wbc_m1 ~ platelets_m3 1.711 0.055 0.055 0.055 0.055
## 209 alt_m1 ~ albumin_m3 1.663 -0.039 -0.039 -0.039 -0.039
## 210 alt_m1 ~ max_hct_m3 1.653 0.039 0.039 0.039 0.039
## 211 wbc_m1 ~ alt_m1 1.624 0.054 0.054 0.054 0.054
## 212 alt_m1 ~ wbc_m1 1.608 -0.039 -0.039 -0.039 -0.039
## 213 wbc_m1 ~ lymph_m1 1.566 -0.053 -0.053 -0.053 -0.053
## 214 max_hct_m3 ~ ast_m1 1.539 0.073 0.073 0.073 0.073
## 215 max_hct_m1 ~~ platelets_m3 1.486 -0.059 -0.059 -0.076 -0.076
## 216 alt_m3 ~~ platelets_m3 1.480 0.048 0.048 0.050 0.050
## 217 alt_m3 ~ platelets_m3 1.480 0.052 0.052 0.052 0.052
## 218 alt_m1 ~ tourn_no_m1 1.474 0.037 0.037 0.037 0.037
## 219 wbc_m3 ~ albumin_m1 1.460 0.074 0.074 0.074 0.074
## 220 alt_m1 ~ platelets_m1 1.430 -0.036 -0.036 -0.036 -0.036
## 221 age_t ~ ast_m1 1.411 0.076 0.076 0.076 0.076
## 222 lymph_m1 ~ tourn_no_m3 1.394 -0.067 -0.067 -0.067 -0.067
## 223 alt_m1 ~ platelets_m3 1.390 -0.036 -0.036 -0.036 -0.036
## 224 alt_m3 ~ lymph_m3 1.368 -0.051 -0.051 -0.051 -0.051
## 225 alt_m3 ~~ lymph_m3 1.368 -0.045 -0.045 -0.048 -0.048
## 226 alt_m1 ~~ wbc_m3 1.309 -0.034 -0.034 -0.050 -0.050
## 227 max_hct_m1 ~ albumin_m3 1.286 -0.058 -0.058 -0.058 -0.058
## 228 max_hct_m3 ~ dhf 1.254 -0.081 -0.081 -0.078 -0.078
## 229 tourn_no_m1 ~~ lymph_m3 1.253 -0.056 -0.056 -0.070 -0.070
## 230 max_hct_m3 ~ platelets_m1 1.241 -0.066 -0.066 -0.066 -0.066
## 231 tourn_no_m3 ~ ast_m1 1.238 0.069 0.069 0.069 0.069
## 232 dhf ~ ast_m3 1.214 0.085 0.085 0.089 0.089
## 233 ast_m1 ~~ wbc_m1 1.211 -0.025 -0.025 -0.048 -0.048
## 234 ast_m1 ~~ albumin_m1 1.186 0.031 0.031 0.047 0.047
## 235 ast_m1 ~ albumin_m1 1.176 0.036 0.036 0.037 0.037
## 236 ast_m1 ~~ platelets_m3 1.155 -0.035 -0.035 -0.047 -0.047
## 237 albumin_m3 ~ wbc_m3 1.154 0.068 0.068 0.068 0.068
## 238 wbc_m3 ~ albumin_m3 1.154 0.066 0.066 0.066 0.066
## 239 age_t ~ wbc_m3 1.154 -0.992 -0.992 -0.992 -0.992
## 240 dhf ~~ ast_m3 1.153 0.047 0.047 0.053 0.053
## 241 dhf ~~ wbc_m3 1.144 -0.084 -0.084 -0.097 -0.097
## 242 tourn_no_m3 ~ alt_m1 1.129 0.066 0.066 0.066 0.066
## 243 max_hct_m3 ~~ ast_m3 1.099 0.041 0.041 0.043 0.043
## 244 alt_m1 ~~ tourn_no_m1 1.039 0.026 0.026 0.044 0.044
## 245 alt_m1 ~ dhf 1.024 0.047 0.047 0.045 0.045
## 246 wbc_m1 ~~ tourn_no_m3 0.976 0.041 0.041 0.062 0.062
## 247 alt_m1 ~~ max_hct_m1 0.927 0.024 0.024 0.042 0.042
## 248 max_hct_m3 ~~ tourn_no_m3 0.910 0.055 0.055 0.060 0.060
## 249 tourn_no_m3 ~ max_hct_m3 0.910 0.063 0.063 0.063 0.063
## 250 max_hct_m3 ~ tourn_no_m3 0.910 0.056 0.056 0.056 0.056
## 251 max_hct_m1 ~~ wbc_m3 0.905 -0.047 -0.047 -0.059 -0.059
## 252 lymph_m1 ~~ tourn_no_m3 0.895 -0.053 -0.053 -0.059 -0.059
## 253 albumin_m1 ~~ tourn_no_m1 0.894 -0.042 -0.042 -0.059 -0.059
## 254 dhf ~~ wbc_m1 0.876 0.048 0.048 0.079 0.079
## 255 dhf ~ wbc_m3 0.876 -0.076 -0.076 -0.079 -0.079
## 256 wbc_m3 ~ max_hct_m1 0.832 -0.057 -0.057 -0.057 -0.057
## 257 lymph_m1 ~~ platelets_m1 0.826 -0.039 -0.039 -0.057 -0.057
## 258 max_hct_m3 ~ tourn_no_m1 0.824 0.053 0.053 0.053 0.053
## 259 ast_m3 ~ max_hct_m3 0.784 0.038 0.038 0.038 0.038
## 260 lymph_m3 ~ dhf 0.778 0.058 0.058 0.056 0.056
## 261 ast_m1 ~ platelets_m3 0.745 -0.029 -0.029 -0.029 -0.029
## 262 alt_m1 ~~ lymph_m1 0.739 -0.024 -0.024 -0.037 -0.037
## 263 alt_m3 ~ albumin_m3 0.736 -0.035 -0.035 -0.035 -0.035
## 264 ast_m1 ~ max_hct_m1 0.733 -0.029 -0.029 -0.029 -0.029
## 265 max_hct_m1 ~~ tourn_no_m3 0.727 -0.043 -0.043 -0.053 -0.053
## 266 platelets_m1 ~ lymph_m1 0.722 -0.040 -0.040 -0.040 -0.040
## 267 dhf ~~ ast_m1 0.721 -0.049 -0.049 -0.071 -0.071
## 268 platelets_m1 ~~ ast_m3 0.680 -0.025 -0.025 -0.034 -0.034
## 269 platelets_m3 ~~ tourn_no_m3 0.668 -0.049 -0.049 -0.051 -0.051
## 270 platelets_m3 ~ tourn_no_m3 0.668 -0.049 -0.049 -0.049 -0.049
## 271 tourn_no_m3 ~ platelets_m3 0.668 -0.053 -0.053 -0.053 -0.053
## 272 ast_m1 ~~ max_hct_m1 0.645 -0.022 -0.022 -0.035 -0.035
## 273 lymph_m1 ~ albumin_m3 0.634 0.045 0.045 0.045 0.045
## 274 ast_m1 ~ platelets_m1 0.622 -0.027 -0.027 -0.027 -0.027
## 275 lymph_m1 ~~ max_hct_m1 0.604 0.036 0.036 0.048 0.048
## 276 lymph_m1 ~ albumin_m1 0.599 0.044 0.044 0.044 0.044
## 277 albumin_m1 ~~ wbc_m3 0.568 0.039 0.039 0.047 0.047
## 278 wbc_m1 ~~ tourn_no_m1 0.565 -0.027 -0.027 -0.047 -0.047
## 279 ast_m1 ~~ lymph_m1 0.556 0.023 0.023 0.032 0.032
## 280 lymph_m1 ~ alt_m1 0.540 -0.042 -0.042 -0.042 -0.042
## 281 alt_m3 ~~ wbc_m3 0.500 0.028 0.028 0.029 0.029
## 282 alt_m3 ~ wbc_m3 0.500 0.030 0.030 0.029 0.029
## 283 dhf ~~ lymph_m1 0.497 -0.084 -0.084 -0.105 -0.105
## 284 dhf ~ lymph_m3 0.497 0.043 0.043 0.045 0.045
## 285 wbc_m1 ~ max_hct_m3 0.496 -0.030 -0.030 -0.030 -0.030
## 286 albumin_m1 ~ wbc_m3 0.488 0.037 0.037 0.037 0.037
## 287 alt_m1 ~~ albumin_m1 0.473 0.018 0.018 0.030 0.030
## 288 platelets_m1 ~ albumin_m3 0.463 -0.032 -0.032 -0.032 -0.032
## 289 lymph_m3 ~ alt_m1 0.448 0.039 0.039 0.039 0.039
## 290 lymph_m3 ~ albumin_m1 0.437 -0.039 -0.039 -0.039 -0.039
## 291 alt_m1 ~ tourn_no_m3 0.436 0.020 0.020 0.020 0.020
## 292 platelets_m1 ~~ lymph_m3 0.430 -0.029 -0.029 -0.041 -0.041
## 293 ast_m1 ~ dhf 0.428 -0.038 -0.038 -0.037 -0.037
## 294 platelets_m1 ~ max_hct_m3 0.420 -0.031 -0.031 -0.031 -0.031
## 295 ast_m1 ~ tourn_no_m3 0.409 -0.022 -0.022 -0.022 -0.022
## 296 ast_m1 ~~ alt_m3 0.408 0.075 0.075 0.097 0.097
## 297 ast_m1 ~ age_t 0.408 -0.022 -0.022 -0.022 -0.022
## 298 ast_m1 ~~ ast_m3 0.408 -0.100 -0.100 -0.130 -0.130
## 299 alt_m1 ~ lymph_m1 0.377 -0.019 -0.019 -0.019 -0.019
## 300 ast_m1 ~ wbc_m3 0.374 0.021 0.021 0.021 0.021
## 301 albumin_m1 ~ wbc_m1 0.358 0.032 0.032 0.032 0.032
## 302 alt_m3 ~ wbc_m1 0.356 -0.025 -0.025 -0.025 -0.025
## 303 dhf ~~ alt_m3 0.349 -0.025 -0.025 -0.029 -0.029
## 304 wbc_m1 ~ tourn_no_m3 0.343 0.025 0.025 0.025 0.025
## 305 ast_m3 ~ age_t 0.328 -0.036 -0.036 -0.036 -0.036
## 306 ast_m3 ~ alt_m3 0.328 -0.282 -0.282 -0.283 -0.283
## 307 ast_m1 ~~ tourn_no_m3 0.326 -0.019 -0.019 -0.025 -0.025
## 308 albumin_m1 ~~ max_hct_m1 0.325 0.024 0.024 0.036 0.036
## 309 lymph_m3 ~~ max_hct_m3 0.323 -0.031 -0.031 -0.035 -0.035
## 310 lymph_m3 ~ max_hct_m3 0.323 -0.035 -0.035 -0.035 -0.035
## 311 max_hct_m3 ~ lymph_m3 0.323 -0.035 -0.035 -0.035 -0.035
## 312 lymph_m1 ~ max_hct_m1 0.313 -0.032 -0.032 -0.032 -0.032
## 313 alt_m1 ~~ platelets_m1 0.310 -0.013 -0.013 -0.024 -0.024
## 314 max_hct_m1 ~ lymph_m1 0.304 -0.028 -0.028 -0.028 -0.028
## 315 lymph_m1 ~ platelets_m1 0.303 -0.031 -0.031 -0.031 -0.031
## 316 lymph_m1 ~ ast_m3 0.298 -0.031 -0.031 -0.031 -0.031
## 317 dhf ~~ lymph_m3 0.292 0.030 0.030 0.037 0.037
## 318 tourn_no_m3 ~ alt_m3 0.291 0.034 0.034 0.034 0.034
## 319 ast_m3 ~ wbc_m1 0.284 0.022 0.022 0.022 0.022
## 320 lymph_m1 ~~ ast_m3 0.281 -0.020 -0.020 -0.022 -0.022
## 321 dhf ~ age_t 0.278 -0.031 -0.031 -0.032 -0.032
## 322 lymph_m1 ~ alt_m3 0.271 -0.029 -0.029 -0.030 -0.030
## 323 tourn_no_m3 ~ albumin_m3 0.261 -0.032 -0.032 -0.032 -0.032
## 324 albumin_m3 ~ tourn_no_m3 0.261 -0.032 -0.032 -0.032 -0.032
## 325 age_t ~ tourn_no_m3 0.261 0.467 0.467 0.467 0.467
## 326 ast_m1 ~~ wbc_m3 0.254 0.017 0.017 0.022 0.022
## 327 wbc_m1 ~~ max_hct_m3 0.245 0.020 0.020 0.031 0.031
## 328 alt_m1 ~~ platelets_m3 0.245 -0.014 -0.014 -0.022 -0.022
## 329 tourn_no_m1 ~~ max_hct_m3 0.230 0.024 0.024 0.030 0.030
## 330 alt_m3 ~ platelets_m1 0.223 0.020 0.020 0.020 0.020
## 331 alt_m3 ~ tourn_no_m1 0.219 -0.019 -0.019 -0.019 -0.019
## 332 max_hct_m1 ~ alt_m1 0.208 -0.023 -0.023 -0.023 -0.023
## 333 alt_m1 ~~ max_hct_m3 0.188 0.012 0.012 0.019 0.019
## 334 albumin_m1 ~ lymph_m1 0.186 0.023 0.023 0.023 0.023
## 335 lymph_m1 ~~ albumin_m1 0.172 0.020 0.020 0.026 0.026
## 336 alt_m3 ~ dhf 0.172 -0.021 -0.021 -0.020 -0.020
## 337 platelets_m1 ~~ alt_m3 0.168 -0.013 -0.013 -0.017 -0.017
## 338 albumin_m1 ~ max_hct_m1 0.167 -0.022 -0.022 -0.022 -0.022
## 339 alt_m1 ~ lymph_m3 0.159 0.012 0.012 0.012 0.012
## 340 wbc_m1 ~~ platelets_m3 0.148 0.016 0.016 0.024 0.024
## 341 max_hct_m1 ~ alt_m3 0.147 0.019 0.019 0.019 0.019
## 342 lymph_m1 ~~ platelets_m3 0.145 -0.021 -0.021 -0.024 -0.024
## 343 wbc_m1 ~ dhf 0.135 -0.021 -0.021 -0.020 -0.020
## 344 alt_m1 ~~ tourn_no_m3 0.134 0.011 0.011 0.016 0.016
## 345 age_t ~ ast_m3 0.134 -0.023 -0.023 -0.023 -0.023
## 346 albumin_m1 ~ alt_m1 0.128 -0.019 -0.019 -0.019 -0.019
## 347 max_hct_m1 ~ tourn_no_m3 0.122 -0.018 -0.018 -0.018 -0.018
## 348 ast_m1 ~ max_hct_m3 0.121 -0.012 -0.012 -0.012 -0.012
## 349 lymph_m3 ~ alt_m3 0.119 0.020 0.020 0.020 0.020
## 350 alt_m3 ~ albumin_m1 0.113 -0.014 -0.014 -0.014 -0.014
## 351 wbc_m1 ~ tourn_no_m1 0.110 -0.014 -0.014 -0.014 -0.014
## 352 tourn_no_m1 ~~ alt_m3 0.109 0.012 0.012 0.014 0.014
## 353 age_t ~ alt_m3 0.098 -0.026 -0.026 -0.026 -0.026
## 354 lymph_m3 ~ tourn_no_m1 0.097 0.018 0.018 0.018 0.018
## 355 ast_m3 ~ lymph_m1 0.096 0.013 0.013 0.013 0.013
## 356 ast_m1 ~ albumin_m3 0.092 0.010 0.010 0.010 0.010
## 357 ast_m1 ~ wbc_m1 0.088 -0.010 -0.010 -0.010 -0.010
## 358 ast_m1 ~~ platelets_m1 0.085 -0.007 -0.007 -0.013 -0.013
## 359 dhf ~ alt_m3 0.071 0.020 0.020 0.021 0.021
## 360 alt_m3 ~ lymph_m1 0.067 -0.011 -0.011 -0.011 -0.011
## 361 albumin_m3 ~ lymph_m1 0.051 0.014 0.014 0.014 0.014
## 362 lymph_m1 ~~ alt_m3 0.051 0.008 0.008 0.009 0.009
## 363 albumin_m1 ~ age_t 0.050 0.012 0.012 0.012 0.012
## 364 age_t ~ albumin_m1 0.050 0.016 0.016 0.016 0.016
## 365 albumin_m3 ~ albumin_m1 0.050 -0.240 -0.240 -0.240 -0.240
## 366 albumin_m1 ~~ lymph_m3 0.049 0.011 0.011 0.014 0.014
## 367 wbc_m3 ~ max_hct_m3 0.048 -0.014 -0.014 -0.014 -0.014
## 368 wbc_m3 ~~ max_hct_m3 0.048 -0.013 -0.013 -0.014 -0.014
## 369 max_hct_m3 ~ wbc_m3 0.048 -0.013 -0.013 -0.013 -0.013
## 370 ast_m1 ~~ tourn_no_m1 0.046 0.006 0.006 0.009 0.009
## 371 lymph_m1 ~ platelets_m3 0.041 0.012 0.012 0.012 0.012
## 372 dhf ~~ alt_m1 0.033 -0.008 -0.008 -0.012 -0.012
## 373 max_hct_m3 ~ wbc_m1 0.032 0.011 0.011 0.011 0.011
## 374 tourn_no_m3 ~ max_hct_m1 0.031 -0.011 -0.011 -0.011 -0.011
## 375 max_hct_m3 ~ albumin_m1 0.028 -0.010 -0.010 -0.010 -0.010
## 376 alt_m3 ~ max_hct_m3 0.027 0.007 0.007 0.007 0.007
## 377 alt_m3 ~~ max_hct_m3 0.027 0.006 0.006 0.007 0.007
## 378 lymph_m1 ~ ast_m1 0.025 -0.009 -0.009 -0.009 -0.009
## 379 ast_m1 ~ tourn_no_m1 0.024 -0.005 -0.005 -0.005 -0.005
## 380 lymph_m3 ~ ast_m1 0.020 -0.008 -0.008 -0.008 -0.008
## 381 ast_m1 ~~ max_hct_m3 0.020 -0.004 -0.004 -0.006 -0.006
## 382 albumin_m1 ~~ alt_m3 0.020 0.005 0.005 0.006 0.006
## 383 alt_m1 ~~ wbc_m1 0.018 -0.003 -0.003 -0.006 -0.006
## 384 albumin_m3 ~ max_hct_m1 0.018 0.008 0.008 0.008 0.008
## 385 albumin_m1 ~ lymph_m3 0.017 0.007 0.007 0.007 0.007
## 386 wbc_m1 ~~ albumin_m1 0.016 0.004 0.004 0.008 0.008
## 387 max_hct_m1 ~ albumin_m1 0.014 -0.006 -0.006 -0.006 -0.006
## 388 alt_m1 ~ albumin_m1 0.010 -0.003 -0.003 -0.003 -0.003
## 389 platelets_m1 ~~ max_hct_m3 0.010 -0.004 -0.004 -0.006 -0.006
## 390 albumin_m3 ~ dhf 0.009 0.007 0.007 0.007 0.007
## 391 tourn_no_m3 ~ lymph_m1 0.009 0.006 0.006 0.006 0.006
## 392 albumin_m1 ~ ast_m1 0.006 0.004 0.004 0.004 0.004
## 393 ast_m1 ~ lymph_m1 0.004 -0.002 -0.002 -0.002 -0.002
## 394 platelets_m1 ~ lymph_m3 0.003 -0.003 -0.003 -0.003 -0.003
## 395 platelets_m3 ~ dhf 0.000 0.001 0.001 0.001 0.001
more adjustment
Further adjustments which sounded reasonable were:
- platelet at the time -1D being influenced by white blood cell at -3d
-
lymphocytes and all white blood cell counts are obviously correlated:
lymph_m1 ~~ wbc_m1 -
platelets and albumin levels at m3 also affect the hepatotoxicity at m1, alongside the alt and ast levels.
ast_m1~ast_m3 + alt_m3+platelets_m3 alt_m1~alt_m3 + ast_m3+albumin_m3 -
not considered initially, but reasonable: influence of age and haematocrit or white blood cell, thought possibly not exactly a direct causal relationship
wbc_m1+max_hct_m1+tourn_no_m1 ~age_t - the hepatotoxicity or liver inflammatory process influencing the later haematocrit levels
max_hct_m1~max_hct_m3+ast_m3
library(lavaan)
model="
dhf~alt_m1+lymph_m1+max_hct_m1+platelets_m1+tourn_no_m1
ast_m1~ast_m3 + alt_m3+platelets_m3
alt_m1~alt_m3 + ast_m3+albumin_m3
wbc_m1~wbc_m3 +ast_m3
lymph_m1~lymph_m3+wbc_m3
albumin_m1~albumin_m3+platelets_m3
max_hct_m1~max_hct_m3+ast_m3
platelets_m1~platelets_m3+wbc_m3
tourn_no_m1~tourn_no_m3
alt_m3~age_t
wbc_m3~age_t
lymph_m3~age_t
max_hct_m3~age_t
platelets_m3~age_t
tourn_no_m3~age_t
wbc_m1+max_hct_m1+tourn_no_m1 ~age_t
ast_m3~~alt_m3
wbc_m3 ~~ lymph_m3+platelets_m3+tourn_no_m3
ast_m1~~alt_m1+tourn_no_m1+max_hct_m1
lymph_m1 ~~ wbc_m1 +tourn_no_m1
platelets_m1 ~~ max_hct_m1+wbc_m1+albumin_m1
"
fit=sem(model=model, data=data,std.ov=TRUE,estimator="MLR",fixed.x = FALSE)
fitmeasures(fit)[c('cfi.robust','tli.robust','rmsea.robust','rmsea.ci.lower.robust' , 'rmsea.ci.upper.robust')]
## cfi.robust tli.robust rmsea.robust
## 0.93149480 0.89890495 0.06814811
## rmsea.ci.lower.robust rmsea.ci.upper.robust
## 0.05613666 0.08017566
modificationindices(fit,standardized = TRUE)%>%arrange(-mi)
## lhs op rhs mi epc sepc.lv sepc.all sepc.nox
## 1 lymph_m3 ~ wbc_m3 14.937 -0.777 -0.777 -0.756 -0.756
## 2 alt_m1 ~ ast_m1 12.800 1.849 1.849 1.833 1.833
## 3 lymph_m1 ~~ lymph_m3 10.959 -0.364 -0.364 -0.432 -0.432
## 4 albumin_m3 ~ alt_m1 10.678 -0.236 -0.236 -0.234 -0.234
## 5 ast_m3 ~ alt_m1 10.582 1.241 1.241 1.234 1.234
## 6 age_t ~ tourn_no_m1 10.114 1.424 1.424 1.412 1.412
## 7 platelets_m3 ~ wbc_m3 10.057 0.503 0.503 0.489 0.489
## 8 platelets_m3 ~ ast_m1 9.755 -0.211 -0.211 -0.207 -0.207
## 9 max_hct_m1 ~~ tourn_no_m1 9.669 0.120 0.120 0.186 0.186
## 10 lymph_m3 ~ platelets_m3 9.526 -0.188 -0.188 -0.188 -0.188
## 11 platelets_m3 ~ lymph_m3 9.526 -0.197 -0.197 -0.197 -0.197
## 12 lymph_m3 ~~ platelets_m3 9.526 -0.173 -0.173 -0.193 -0.193
## 13 age_t ~ lymph_m1 9.422 -0.236 -0.236 -0.237 -0.237
## 14 lymph_m1 ~ age_t 9.374 -0.192 -0.192 -0.191 -0.191
## 15 lymph_m3 ~ lymph_m1 9.359 -0.370 -0.370 -0.372 -0.372
## 16 alt_m1 ~~ ast_m3 9.300 0.445 0.445 0.643 0.643
## 17 alt_m1 ~ age_t 9.300 0.097 0.097 0.098 0.098
## 18 alt_m1 ~~ alt_m3 9.300 -0.332 -0.332 -0.482 -0.482
## 19 ast_m3 ~ platelets_m3 9.166 -0.128 -0.128 -0.128 -0.128
## 20 albumin_m3 ~ platelets_m3 9.025 0.194 0.194 0.194 0.194
## 21 age_t ~ platelets_m3 9.025 -2.835 -2.835 -2.835 -2.835
## 22 lymph_m1 ~~ wbc_m3 9.007 -0.310 -0.310 -0.362 -0.362
## 23 platelets_m3 ~ albumin_m3 8.970 0.172 0.172 0.172 0.173
## 24 albumin_m3 ~ ast_m3 8.962 -0.186 -0.186 -0.186 -0.186
## 25 platelets_m3 ~ albumin_m1 8.453 0.269 0.269 0.268 0.268
## 26 tourn_no_m1 ~ platelets_m1 8.144 -0.155 -0.155 -0.151 -0.151
## 27 alt_m1 ~~ albumin_m1 8.095 0.099 0.099 0.171 0.171
## 28 ast_m3 ~ wbc_m3 7.964 -0.121 -0.121 -0.118 -0.118
## 29 albumin_m3 ~ alt_m3 7.908 -0.176 -0.176 -0.176 -0.176
## 30 alt_m3 ~ alt_m1 7.765 -0.835 -0.835 -0.828 -0.828
## 31 tourn_no_m1 ~ max_hct_m1 7.559 0.154 0.154 0.155 0.155
## 32 wbc_m1 ~ albumin_m3 7.502 -0.103 -0.103 -0.101 -0.102
## 33 tourn_no_m1 ~ ast_m3 7.374 0.139 0.139 0.141 0.141
## 34 platelets_m3 ~~ ast_m3 7.325 -0.102 -0.102 -0.107 -0.107
## 35 ast_m3 ~ platelets_m1 7.244 -0.116 -0.116 -0.112 -0.112
## 36 platelets_m3 ~ ast_m3 7.191 -0.154 -0.154 -0.154 -0.154
## 37 platelets_m3 ~ alt_m1 7.156 -0.154 -0.154 -0.154 -0.154
## 38 tourn_no_m1 ~ alt_m1 7.121 0.138 0.138 0.138 0.138
## 39 max_hct_m1 ~ dhf 7.021 0.206 0.206 0.200 0.200
## 40 ast_m3 ~ tourn_no_m1 6.452 0.107 0.107 0.106 0.106
## 41 albumin_m3 ~ ast_m1 6.231 -0.158 -0.158 -0.155 -0.155
## 42 alt_m1 ~ platelets_m3 6.112 -0.107 -0.107 -0.108 -0.108
## 43 tourn_no_m1 ~ ast_m1 6.049 0.153 0.153 0.152 0.152
## 44 tourn_no_m3 ~ wbc_m3 5.931 -0.346 -0.346 -0.337 -0.337
## 45 wbc_m3 ~ lymph_m1 5.879 -0.302 -0.302 -0.312 -0.312
## 46 lymph_m3 ~ tourn_no_m3 5.843 0.143 0.143 0.143 0.143
## 47 tourn_no_m3 ~ lymph_m3 5.843 0.160 0.160 0.160 0.160
## 48 lymph_m3 ~~ tourn_no_m3 5.843 0.140 0.140 0.151 0.151
## 49 tourn_no_m1 ~~ tourn_no_m3 5.773 -0.745 -0.745 -0.903 -0.903
## 50 tourn_no_m1 ~~ wbc_m3 5.773 -0.104 -0.104 -0.131 -0.131
## 51 wbc_m1 ~ albumin_m1 5.762 -0.168 -0.168 -0.165 -0.165
## 52 albumin_m3 ~ max_hct_m3 5.622 0.157 0.157 0.157 0.157
## 53 max_hct_m3 ~ albumin_m3 5.622 0.139 0.139 0.139 0.140
## 54 age_t ~ max_hct_m3 5.622 -2.289 -2.289 -2.289 -2.289
## 55 wbc_m1 ~ lymph_m3 5.508 0.103 0.103 0.102 0.102
## 56 ast_m3 ~ tourn_no_m3 5.457 0.097 0.097 0.097 0.097
## 57 wbc_m1 ~ lymph_m1 5.426 0.243 0.243 0.241 0.241
## 58 ast_m3 ~ albumin_m1 5.424 -0.096 -0.096 -0.096 -0.096
## 59 alt_m1 ~ wbc_m1 5.329 -0.080 -0.080 -0.082 -0.082
## 60 lymph_m1 ~ max_hct_m3 5.155 -0.124 -0.124 -0.124 -0.124
## 61 ast_m3 ~ ast_m1 5.114 0.710 0.710 0.699 0.699
## 62 max_hct_m1 ~~ lymph_m3 5.049 -0.091 -0.091 -0.125 -0.125
## 63 wbc_m1 ~~ lymph_m3 5.041 0.074 0.074 0.123 0.123
## 64 lymph_m1 ~ tourn_no_m1 4.923 -0.236 -0.236 -0.232 -0.232
## 65 tourn_no_m1 ~ alt_m3 4.882 0.114 0.114 0.115 0.115
## 66 wbc_m3 ~ tourn_no_m1 4.834 -0.138 -0.138 -0.141 -0.141
## 67 tourn_no_m1 ~ wbc_m3 4.769 -0.120 -0.120 -0.118 -0.118
## 68 max_hct_m1 ~~ ast_m3 4.762 -0.090 -0.090 -0.117 -0.117
## 69 max_hct_m1 ~~ alt_m3 4.762 0.067 0.067 0.088 0.088
## 70 max_hct_m1 ~ alt_m3 4.762 0.156 0.156 0.157 0.157
## 71 tourn_no_m3 ~~ ast_m3 4.682 0.087 0.087 0.088 0.088
## 72 alt_m1 ~ albumin_m1 4.592 0.106 0.106 0.106 0.106
## 73 lymph_m3 ~ max_hct_m1 4.547 -0.126 -0.126 -0.125 -0.125
## 74 max_hct_m1 ~ tourn_no_m1 4.437 0.102 0.102 0.102 0.102
## 75 wbc_m3 ~ alt_m1 4.413 -0.111 -0.111 -0.113 -0.113
## 76 ast_m3 ~ dhf 4.406 0.096 0.096 0.093 0.093
## 77 ast_m1 ~~ lymph_m3 4.344 -0.060 -0.060 -0.084 -0.084
## 78 wbc_m3 ~ ast_m3 4.321 -0.109 -0.109 -0.112 -0.112
## 79 age_t ~ alt_m1 4.104 0.130 0.130 0.130 0.130
## 80 albumin_m1 ~ ast_m3 4.071 -0.102 -0.102 -0.102 -0.102
## 81 dhf ~ max_hct_m3 4.046 -0.138 -0.138 -0.142 -0.142
## 82 max_hct_m1 ~ platelets_m3 3.830 -0.098 -0.098 -0.099 -0.099
## 83 tourn_no_m1 ~~ lymph_m3 3.829 -0.087 -0.087 -0.112 -0.112
## 84 ast_m3 ~ lymph_m3 3.793 0.083 0.083 0.083 0.083
## 85 alt_m1 ~ platelets_m1 3.791 -0.069 -0.069 -0.067 -0.067
## 86 alt_m1 ~ wbc_m3 3.779 -0.063 -0.063 -0.062 -0.062
## 87 max_hct_m1 ~~ wbc_m3 3.756 -0.078 -0.078 -0.105 -0.105
## 88 age_t ~ max_hct_m1 3.685 0.573 0.573 0.570 0.570
## 89 dhf ~~ max_hct_m1 3.648 0.127 0.127 0.186 0.186
## 90 max_hct_m1 ~ platelets_m1 3.619 -0.135 -0.135 -0.131 -0.131
## 91 alt_m3 ~ max_hct_m1 3.553 0.085 0.085 0.084 0.084
## 92 alt_m1 ~ tourn_no_m1 3.544 0.072 0.072 0.072 0.072
## 93 alt_m3 ~ ast_m1 3.489 -0.470 -0.470 -0.462 -0.462
## 94 albumin_m3 ~ tourn_no_m1 3.357 -0.118 -0.118 -0.117 -0.117
## 95 platelets_m1 ~ age_t 3.234 -0.080 -0.080 -0.083 -0.083
## 96 dhf ~~ max_hct_m3 3.181 -0.106 -0.106 -0.128 -0.128
## 97 max_hct_m3 ~ ast_m3 3.137 0.104 0.104 0.104 0.104
## 98 ast_m1 ~ lymph_m3 3.107 -0.059 -0.059 -0.060 -0.060
## 99 tourn_no_m1 ~ albumin_m1 3.102 -0.091 -0.091 -0.091 -0.091
## 100 tourn_no_m1 ~ albumin_m3 3.085 -0.090 -0.090 -0.091 -0.091
## 101 wbc_m3 ~ ast_m1 3.085 -0.093 -0.093 -0.095 -0.095
## 102 wbc_m3 ~ alt_m3 3.020 -0.091 -0.091 -0.094 -0.094
## 103 wbc_m1 ~ alt_m3 2.971 -0.098 -0.098 -0.097 -0.097
## 104 wbc_m1 ~~ alt_m3 2.971 -0.042 -0.042 -0.066 -0.066
## 105 wbc_m1 ~~ ast_m3 2.971 0.057 0.057 0.089 0.089
## 106 lymph_m1 ~ dhf 2.913 -0.184 -0.184 -0.177 -0.177
## 107 tourn_no_m1 ~ platelets_m3 2.853 -0.090 -0.090 -0.091 -0.091
## 108 dhf ~ albumin_m1 2.755 0.172 0.172 0.178 0.178
## 109 max_hct_m1 ~ lymph_m3 2.718 -0.083 -0.083 -0.083 -0.083
## 110 max_hct_m1 ~ albumin_m3 2.718 -0.078 -0.078 -0.078 -0.078
## 111 platelets_m3 ~ platelets_m1 2.694 0.296 0.296 0.286 0.286
## 112 lymph_m3 ~ albumin_m3 2.691 -0.089 -0.089 -0.089 -0.089
## 113 tourn_no_m3 ~ ast_m3 2.620 0.099 0.099 0.099 0.099
## 114 lymph_m3 ~ wbc_m1 2.611 0.126 0.126 0.128 0.128
## 115 platelets_m1 ~ ast_m1 2.594 -0.069 -0.069 -0.070 -0.070
## 116 age_t ~ platelets_m1 2.593 -0.146 -0.146 -0.141 -0.141
## 117 max_hct_m3 ~ platelets_m3 2.590 -0.098 -0.098 -0.098 -0.098
## 118 albumin_m3 ~ wbc_m1 2.588 -0.103 -0.103 -0.104 -0.104
## 119 tourn_no_m1 ~ wbc_m1 2.580 -0.086 -0.086 -0.088 -0.088
## 120 age_t ~ lymph_m3 2.572 1.550 1.550 1.550 1.550
## 121 albumin_m3 ~ lymph_m3 2.572 -0.106 -0.106 -0.106 -0.106
## 122 tourn_no_m1 ~~ ast_m3 2.556 0.054 0.054 0.065 0.065
## 123 max_hct_m3 ~ alt_m1 2.554 0.094 0.094 0.094 0.094
## 124 tourn_no_m3 ~ albumin_m1 2.539 -0.098 -0.098 -0.097 -0.097
## 125 platelets_m3 ~ max_hct_m3 2.509 -0.097 -0.097 -0.097 -0.097
## 126 max_hct_m3 ~~ platelets_m3 2.509 -0.085 -0.085 -0.094 -0.094
## 127 platelets_m3 ~ max_hct_m1 2.482 -0.099 -0.099 -0.098 -0.098
## 128 alt_m1 ~ max_hct_m3 2.449 0.048 0.048 0.049 0.049
## 129 lymph_m1 ~ tourn_no_m3 2.434 -0.087 -0.087 -0.086 -0.086
## 130 albumin_m3 ~ platelets_m1 2.431 0.102 0.102 0.099 0.099
## 131 dhf ~ albumin_m3 2.430 0.086 0.086 0.089 0.089
## 132 wbc_m3 ~ dhf 2.420 -0.090 -0.090 -0.090 -0.090
## 133 max_hct_m3 ~ lymph_m1 2.296 -0.089 -0.089 -0.089 -0.089
## 134 platelets_m1 ~ alt_m1 2.295 -0.063 -0.063 -0.065 -0.065
## 135 tourn_no_m3 ~ dhf 2.292 0.111 0.111 0.108 0.108
## 136 alt_m1 ~ max_hct_m1 2.281 0.056 0.056 0.056 0.056
## 137 tourn_no_m1 ~ dhf 2.280 0.136 0.136 0.133 0.133
## 138 platelets_m1 ~ tourn_no_m1 2.248 -0.061 -0.061 -0.063 -0.063
## 139 max_hct_m1 ~ wbc_m3 2.222 -0.075 -0.075 -0.074 -0.074
## 140 tourn_no_m3 ~ platelets_m1 2.186 -0.099 -0.099 -0.095 -0.095
## 141 alt_m3 ~~ tourn_no_m3 2.124 -0.058 -0.058 -0.059 -0.059
## 142 albumin_m1 ~~ max_hct_m3 2.101 -0.068 -0.068 -0.087 -0.087
## 143 max_hct_m3 ~ alt_m3 2.065 0.085 0.085 0.085 0.085
## 144 albumin_m1 ~ age_t 2.053 0.075 0.075 0.075 0.075
## 145 lymph_m1 ~~ tourn_no_m3 2.052 -0.076 -0.076 -0.086 -0.086
## 146 alt_m3 ~ tourn_no_m3 2.052 -0.059 -0.059 -0.059 -0.059
## 147 lymph_m1 ~~ max_hct_m3 2.021 -0.072 -0.072 -0.085 -0.085
## 148 albumin_m1 ~ alt_m3 2.000 -0.071 -0.071 -0.072 -0.072
## 149 platelets_m3 ~ wbc_m1 1.954 0.112 0.112 0.114 0.114
## 150 platelets_m1 ~~ platelets_m3 1.927 -0.207 -0.207 -0.304 -0.304
## 151 dhf ~ platelets_m3 1.920 0.099 0.099 0.102 0.102
## 152 wbc_m1 ~ platelets_m3 1.887 0.058 0.058 0.057 0.057
## 153 ast_m3 ~ albumin_m3 1.857 -0.056 -0.056 -0.056 -0.056
## 154 dhf ~~ platelets_m3 1.841 0.080 0.080 0.094 0.094
## 155 lymph_m1 ~~ max_hct_m1 1.830 0.055 0.055 0.079 0.079
## 156 platelets_m3 ~ tourn_no_m1 1.768 -0.080 -0.080 -0.079 -0.079
## 157 ast_m3 ~ wbc_m1 1.749 -0.061 -0.061 -0.062 -0.062
## 158 platelets_m1 ~ dhf 1.711 -0.086 -0.086 -0.086 -0.086
## 159 max_hct_m1 ~~ platelets_m3 1.695 -0.058 -0.058 -0.077 -0.077
## 160 wbc_m3 ~ max_hct_m1 1.673 -0.074 -0.074 -0.076 -0.076
## 161 wbc_m1 ~ platelets_m1 1.671 0.098 0.098 0.094 0.094
## 162 dhf ~ tourn_no_m3 1.625 0.083 0.083 0.086 0.086
## 163 wbc_m1 ~~ wbc_m3 1.614 0.085 0.085 0.139 0.139
## 164 lymph_m3 ~~ ast_m3 1.602 0.045 0.045 0.048 0.048
## 165 max_hct_m3 ~ ast_m1 1.582 0.075 0.075 0.074 0.074
## 166 max_hct_m1 ~ wbc_m1 1.571 -0.063 -0.063 -0.064 -0.064
## 167 alt_m3 ~~ platelets_m3 1.545 0.047 0.047 0.049 0.049
## 168 albumin_m1 ~~ ast_m3 1.517 -0.041 -0.041 -0.049 -0.049
## 169 dhf ~~ ast_m3 1.484 0.047 0.047 0.053 0.053
## 170 alt_m3 ~ platelets_m3 1.480 0.052 0.052 0.052 0.052
## 171 platelets_m3 ~ alt_m3 1.411 -0.068 -0.068 -0.069 -0.069
## 172 alt_m3 ~~ lymph_m3 1.401 -0.042 -0.042 -0.045 -0.045
## 173 wbc_m3 ~~ ast_m3 1.374 -0.040 -0.040 -0.042 -0.042
## 174 lymph_m1 ~ platelets_m3 1.373 0.068 0.068 0.067 0.067
## 175 alt_m3 ~ lymph_m3 1.368 -0.051 -0.051 -0.051 -0.051
## 176 dhf ~~ tourn_no_m3 1.351 0.072 0.072 0.082 0.082
## 177 max_hct_m3 ~ platelets_m1 1.336 -0.071 -0.071 -0.069 -0.069
## 178 dhf ~~ tourn_no_m1 1.312 -0.096 -0.096 -0.131 -0.131
## 179 platelets_m1 ~ tourn_no_m3 1.269 -0.046 -0.046 -0.047 -0.047
## 180 tourn_no_m1 ~ lymph_m3 1.242 -0.062 -0.062 -0.062 -0.062
## 181 max_hct_m1 ~~ tourn_no_m3 1.227 -0.051 -0.051 -0.066 -0.066
## 182 wbc_m1 ~ dhf 1.225 -0.146 -0.146 -0.140 -0.140
## 183 albumin_m3 ~ wbc_m3 1.221 0.072 0.072 0.070 0.070
## 184 age_t ~ wbc_m3 1.221 -1.050 -1.050 -1.022 -1.022
## 185 ast_m1 ~~ ast_m3 1.210 -0.178 -0.178 -0.235 -0.235
## 186 ast_m1 ~ age_t 1.210 -0.039 -0.039 -0.040 -0.040
## 187 ast_m1 ~~ alt_m3 1.210 0.133 0.133 0.176 0.176
## 188 alt_m1 ~~ lymph_m1 1.177 -0.029 -0.029 -0.047 -0.047
## 189 ast_m1 ~ tourn_no_m1 1.175 -0.066 -0.066 -0.066 -0.066
## 190 wbc_m1 ~~ platelets_m3 1.174 0.039 0.039 0.063 0.063
## 191 ast_m1 ~ albumin_m1 1.163 -0.083 -0.083 -0.084 -0.084
## 192 max_hct_m3 ~~ ast_m3 1.099 0.041 0.041 0.043 0.043
## 193 alt_m1 ~~ lymph_m3 1.081 0.027 0.027 0.042 0.042
## 194 age_t ~ ast_m1 1.074 0.068 0.068 0.067 0.067
## 195 albumin_m1 ~~ tourn_no_m3 1.072 -0.051 -0.051 -0.061 -0.061
## 196 ast_m1 ~ wbc_m3 1.053 0.037 0.037 0.036 0.036
## 197 alt_m1 ~ dhf 1.048 0.057 0.057 0.056 0.056
## 198 albumin_m1 ~ wbc_m1 1.044 -0.070 -0.070 -0.072 -0.072
## 199 dhf ~ ast_m3 1.039 0.078 0.078 0.081 0.081
## 200 ast_m3 ~ max_hct_m1 1.011 -0.052 -0.052 -0.051 -0.051
## 201 lymph_m1 ~ alt_m1 1.003 -0.055 -0.055 -0.054 -0.054
## 202 alt_m1 ~~ platelets_m3 1.002 -0.037 -0.037 -0.056 -0.056
## 203 dhf ~~ lymph_m1 0.961 -0.108 -0.108 -0.136 -0.136
## 204 alt_m1 ~~ tourn_no_m1 0.947 0.035 0.035 0.060 0.060
## 205 platelets_m1 ~~ tourn_no_m3 0.945 -0.038 -0.038 -0.054 -0.054
## 206 albumin_m1 ~~ platelets_m3 0.939 0.116 0.116 0.144 0.144
## 207 tourn_no_m3 ~ max_hct_m3 0.934 0.063 0.063 0.063 0.063
## 208 max_hct_m3 ~~ tourn_no_m3 0.934 0.055 0.055 0.059 0.059
## 209 dhf ~ ast_m1 0.915 0.164 0.164 0.167 0.167
## 210 max_hct_m3 ~ tourn_no_m3 0.910 0.056 0.056 0.056 0.056
## 211 lymph_m1 ~ wbc_m1 0.905 0.193 0.193 0.194 0.194
## 212 ast_m1 ~ albumin_m3 0.889 -0.045 -0.045 -0.045 -0.045
## 213 ast_m1 ~ alt_m1 0.889 1.128 1.128 1.138 1.138
## 214 max_hct_m3 ~ tourn_no_m1 0.874 0.057 0.057 0.056 0.056
## 215 lymph_m3 ~ platelets_m1 0.847 -0.056 -0.056 -0.054 -0.054
## 216 tourn_no_m1 ~~ platelets_m3 0.843 -0.043 -0.043 -0.054 -0.054
## 217 dhf ~~ alt_m3 0.818 -0.033 -0.033 -0.038 -0.038
## 218 age_t ~ albumin_m1 0.814 0.070 0.070 0.069 0.069
## 219 albumin_m1 ~ max_hct_m3 0.806 -0.045 -0.045 -0.045 -0.045
## 220 max_hct_m1 ~ ast_m1 0.797 -0.074 -0.074 -0.074 -0.074
## 221 albumin_m1 ~ tourn_no_m3 0.786 -0.044 -0.044 -0.045 -0.045
## 222 ast_m3 ~ max_hct_m3 0.784 0.038 0.038 0.038 0.038
## 223 wbc_m1 ~ alt_m1 0.783 -0.046 -0.046 -0.045 -0.045
## 224 ast_m1 ~ wbc_m1 0.744 0.038 0.038 0.039 0.039
## 225 alt_m1 ~~ platelets_m1 0.741 -0.018 -0.018 -0.036 -0.036
## 226 alt_m3 ~ albumin_m3 0.736 -0.035 -0.035 -0.035 -0.035
## 227 max_hct_m1 ~ albumin_m1 0.715 -0.041 -0.041 -0.041 -0.041
## 228 platelets_m1 ~ max_hct_m1 0.705 -0.057 -0.057 -0.059 -0.059
## 229 max_hct_m3 ~ max_hct_m1 0.696 -0.231 -0.231 -0.230 -0.230
## 230 ast_m1 ~~ lymph_m1 0.694 0.025 0.025 0.037 0.037
## 231 tourn_no_m3 ~ ast_m1 0.683 0.051 0.051 0.051 0.051
## 232 platelets_m3 ~ tourn_no_m3 0.668 -0.049 -0.049 -0.049 -0.049
## 233 tourn_no_m3 ~ platelets_m3 0.668 -0.053 -0.053 -0.053 -0.053
## 234 platelets_m3 ~~ tourn_no_m3 0.668 -0.049 -0.049 -0.051 -0.051
## 235 lymph_m1 ~ alt_m3 0.667 -0.045 -0.045 -0.045 -0.045
## 236 lymph_m3 ~ ast_m1 0.661 -0.045 -0.045 -0.044 -0.044
## 237 max_hct_m1 ~ tourn_no_m3 0.657 -0.038 -0.038 -0.038 -0.038
## 238 tourn_no_m3 ~ tourn_no_m1 0.649 -0.256 -0.256 -0.254 -0.254
## 239 dhf ~~ wbc_m3 0.629 -0.038 -0.038 -0.045 -0.045
## 240 platelets_m1 ~~ tourn_no_m1 0.628 -0.026 -0.026 -0.044 -0.044
## 241 max_hct_m3 ~ dhf 0.624 -0.056 -0.056 -0.054 -0.054
## 242 platelets_m1 ~~ wbc_m3 0.620 -0.062 -0.062 -0.092 -0.092
## 243 alt_m3 ~ dhf 0.593 -0.034 -0.034 -0.033 -0.033
## 244 lymph_m1 ~~ platelets_m3 0.566 0.037 0.037 0.043 0.043
## 245 platelets_m1 ~~ ast_m3 0.557 -0.020 -0.020 -0.029 -0.029
## 246 alt_m3 ~ wbc_m3 0.529 0.031 0.031 0.030 0.030
## 247 dhf ~ wbc_m3 0.525 -0.047 -0.047 -0.048 -0.048
## 248 tourn_no_m3 ~ alt_m1 0.508 0.044 0.044 0.044 0.044
## 249 lymph_m3 ~ albumin_m1 0.505 -0.039 -0.039 -0.038 -0.038
## 250 platelets_m1 ~ wbc_m1 0.496 0.114 0.114 0.120 0.120
## 251 ast_m1 ~~ platelets_m3 0.484 -0.055 -0.055 -0.075 -0.075
## 252 platelets_m1 ~ lymph_m3 0.471 0.029 0.029 0.030 0.030
## 253 albumin_m1 ~ tourn_no_m1 0.470 -0.035 -0.035 -0.035 -0.035
## 254 alt_m1 ~ tourn_no_m3 0.445 0.020 0.020 0.021 0.021
## 255 ast_m1 ~ max_hct_m1 0.442 -0.035 -0.035 -0.036 -0.036
## 256 albumin_m1 ~~ lymph_m3 0.436 0.029 0.029 0.036 0.036
## 257 ast_m1 ~ tourn_no_m3 0.431 -0.022 -0.022 -0.022 -0.022
## 258 platelets_m3 ~ lymph_m1 0.415 -0.038 -0.038 -0.038 -0.038
## 259 dhf ~ lymph_m3 0.403 0.039 0.039 0.040 0.040
## 260 albumin_m1 ~ alt_m1 0.399 0.032 0.032 0.032 0.032
## 261 wbc_m1 ~~ tourn_no_m3 0.392 0.023 0.023 0.036 0.036
## 262 age_t ~ wbc_m1 0.390 0.141 0.141 0.143 0.143
## 263 lymph_m1 ~ max_hct_m1 0.388 -0.034 -0.034 -0.034 -0.034
## 264 alt_m1 ~ lymph_m1 0.386 -0.019 -0.019 -0.019 -0.019
## 265 alt_m3 ~ wbc_m1 0.381 -0.026 -0.026 -0.027 -0.027
## 266 alt_m1 ~~ wbc_m1 0.378 -0.016 -0.016 -0.036 -0.036
## 267 alt_m1 ~~ wbc_m3 0.378 -0.016 -0.016 -0.024 -0.024
## 268 alt_m1 ~~ max_hct_m3 0.352 0.017 0.017 0.026 0.026
## 269 alt_m1 ~~ max_hct_m1 0.349 -0.019 -0.019 -0.036 -0.036
## 270 lymph_m1 ~ ast_m3 0.342 -0.032 -0.032 -0.032 -0.032
## 271 platelets_m1 ~ ast_m3 0.331 -0.025 -0.025 -0.025 -0.025
## 272 ast_m3 ~ age_t 0.328 -0.036 -0.036 -0.036 -0.036
## 273 ast_m3 ~ alt_m3 0.328 -0.282 -0.282 -0.283 -0.283
## 274 tourn_no_m3 ~ albumin_m3 0.328 -0.035 -0.035 -0.035 -0.035
## 275 lymph_m3 ~ ast_m3 0.327 0.031 0.031 0.031 0.031
## 276 max_hct_m3 ~ lymph_m3 0.323 -0.035 -0.035 -0.035 -0.035
## 277 wbc_m3 ~ wbc_m1 0.316 0.084 0.084 0.087 0.087
## 278 ast_m1 ~ max_hct_m3 0.305 -0.019 -0.019 -0.019 -0.019
## 279 dhf ~ age_t 0.299 -0.034 -0.034 -0.035 -0.035
## 280 wbc_m1 ~ tourn_no_m3 0.294 0.021 0.021 0.020 0.020
## 281 ast_m1 ~~ tourn_no_m3 0.291 -0.018 -0.018 -0.023 -0.023
## 282 dhf ~~ alt_m1 0.278 -0.028 -0.028 -0.046 -0.046
## 283 ast_m1 ~~ platelets_m1 0.275 -0.012 -0.012 -0.023 -0.023
## 284 age_t ~ tourn_no_m3 0.261 0.467 0.467 0.467 0.467
## 285 albumin_m3 ~ tourn_no_m3 0.261 -0.032 -0.032 -0.032 -0.032
## 286 albumin_m1 ~~ tourn_no_m1 0.252 -0.021 -0.021 -0.030 -0.030
## 287 ast_m1 ~ dhf 0.248 -0.063 -0.063 -0.062 -0.062
## 288 platelets_m1 ~~ alt_m3 0.243 0.013 0.013 0.018 0.018
## 289 alt_m3 ~ platelets_m1 0.240 0.021 0.021 0.020 0.020
## 290 alt_m3 ~ tourn_no_m1 0.232 -0.020 -0.020 -0.020 -0.020
## 291 lymph_m3 ~~ max_hct_m3 0.215 -0.023 -0.023 -0.027 -0.027
## 292 lymph_m3 ~ max_hct_m3 0.215 -0.027 -0.027 -0.027 -0.027
## 293 platelets_m1 ~ max_hct_m3 0.200 -0.019 -0.019 -0.019 -0.019
## 294 lymph_m3 ~ tourn_no_m1 0.199 -0.025 -0.025 -0.025 -0.025
## 295 dhf ~~ platelets_m1 0.194 -0.025 -0.025 -0.040 -0.040
## 296 albumin_m1 ~ platelets_m1 0.188 -0.078 -0.078 -0.076 -0.076
## 297 wbc_m3 ~ platelets_m1 0.184 0.059 0.059 0.059 0.059
## 298 dhf ~ wbc_m1 0.182 -0.040 -0.040 -0.042 -0.042
## 299 wbc_m1 ~~ tourn_no_m1 0.176 -0.013 -0.013 -0.025 -0.025
## 300 wbc_m3 ~ albumin_m3 0.174 -0.022 -0.022 -0.023 -0.023
## 301 max_hct_m1 ~ lymph_m1 0.165 0.019 0.019 0.019 0.019
## 302 tourn_no_m3 ~ max_hct_m1 0.157 -0.026 -0.026 -0.026 -0.026
## 303 tourn_no_m3 ~ lymph_m1 0.153 -0.024 -0.024 -0.024 -0.024
## 304 lymph_m1 ~ platelets_m1 0.145 0.024 0.024 0.023 0.023
## 305 albumin_m3 ~ dhf 0.142 0.025 0.025 0.024 0.024
## 306 age_t ~ ast_m3 0.134 -0.023 -0.023 -0.023 -0.023
## 307 albumin_m1 ~~ max_hct_m1 0.128 0.014 0.014 0.022 0.022
## 308 lymph_m3 ~ alt_m3 0.126 -0.019 -0.019 -0.019 -0.019
## 309 albumin_m1 ~ lymph_m1 0.125 0.018 0.018 0.018 0.018
## 310 alt_m3 ~ albumin_m1 0.113 -0.014 -0.014 -0.014 -0.014
## 311 age_t ~ dhf 0.107 0.025 0.025 0.024 0.024
## 312 lymph_m1 ~~ ast_m3 0.106 -0.012 -0.012 -0.013 -0.013
## 313 lymph_m1 ~ albumin_m1 0.102 0.018 0.018 0.017 0.017
## 314 age_t ~ alt_m3 0.098 -0.026 -0.026 -0.026 -0.026
## 315 albumin_m1 ~ ast_m1 0.098 0.019 0.019 0.019 0.019
## 316 albumin_m1 ~ max_hct_m1 0.095 0.016 0.016 0.016 0.016
## 317 ast_m3 ~ lymph_m1 0.094 0.013 0.013 0.013 0.013
## 318 tourn_no_m1 ~~ max_hct_m3 0.087 0.014 0.014 0.018 0.018
## 319 tourn_no_m1 ~ max_hct_m3 0.087 0.016 0.016 0.016 0.016
## 320 alt_m1 ~ lymph_m3 0.086 0.009 0.009 0.009 0.009
## 321 platelets_m1 ~ lymph_m1 0.086 0.013 0.013 0.013 0.013
## 322 platelets_m1 ~ alt_m3 0.085 -0.012 -0.012 -0.013 -0.013
## 323 albumin_m1 ~ wbc_m3 0.082 -0.016 -0.016 -0.016 -0.016
## 324 lymph_m1 ~ ast_m1 0.082 -0.016 -0.016 -0.016 -0.016
## 325 alt_m3 ~~ wbc_m3 0.074 -0.009 -0.009 -0.010 -0.010
## 326 tourn_no_m1 ~~ alt_m3 0.070 0.009 0.009 0.011 0.011
## 327 wbc_m3 ~ albumin_m1 0.066 -0.014 -0.014 -0.014 -0.014
## 328 alt_m3 ~ lymph_m1 0.065 -0.011 -0.011 -0.011 -0.011
## 329 tourn_no_m3 ~ alt_m3 0.062 0.015 0.015 0.015 0.015
## 330 albumin_m3 ~ albumin_m1 0.056 0.054 0.054 0.054 0.054
## 331 alt_m1 ~~ tourn_no_m3 0.051 0.007 0.007 0.010 0.010
## 332 max_hct_m3 ~ wbc_m3 0.051 -0.014 -0.014 -0.013 -0.013
## 333 albumin_m3 ~ lymph_m1 0.050 0.014 0.014 0.014 0.014
## 334 ast_m1 ~~ max_hct_m3 0.043 -0.006 -0.006 -0.009 -0.009
## 335 albumin_m1 ~ lymph_m3 0.040 0.010 0.010 0.010 0.010
## 336 lymph_m3 ~ alt_m1 0.037 -0.010 -0.010 -0.010 -0.010
## 337 platelets_m1 ~ albumin_m1 0.036 -0.015 -0.015 -0.015 -0.015
## 338 platelets_m3 ~ dhf 0.036 0.013 0.013 0.013 0.013
## 339 lymph_m1 ~~ albumin_m1 0.035 0.008 0.008 0.011 0.011
## 340 max_hct_m3 ~ wbc_m1 0.033 0.011 0.011 0.011 0.011
## 341 wbc_m1 ~~ max_hct_m3 0.031 -0.006 -0.006 -0.010 -0.010
## 342 wbc_m1 ~ max_hct_m3 0.031 -0.007 -0.007 -0.007 -0.007
## 343 wbc_m1 ~ ast_m1 0.031 -0.012 -0.012 -0.011 -0.011
## 344 max_hct_m3 ~ albumin_m1 0.028 -0.010 -0.010 -0.010 -0.010
## 345 alt_m3 ~~ max_hct_m3 0.027 0.006 0.006 0.007 0.007
## 346 alt_m3 ~ max_hct_m3 0.027 0.007 0.007 0.007 0.007
## 347 ast_m1 ~ platelets_m1 0.025 -0.007 -0.007 -0.007 -0.007
## 348 wbc_m3 ~~ max_hct_m3 0.024 0.008 0.008 0.008 0.008
## 349 wbc_m3 ~ max_hct_m3 0.024 0.009 0.009 0.009 0.009
## 350 albumin_m3 ~ max_hct_m1 0.020 0.010 0.010 0.010 0.010
## 351 albumin_m1 ~~ alt_m3 0.018 -0.004 -0.004 -0.005 -0.005
## 352 platelets_m1 ~ albumin_m3 0.017 -0.005 -0.005 -0.006 -0.006
## 353 platelets_m1 ~~ max_hct_m3 0.017 0.005 0.005 0.008 0.008
## 354 dhf ~ alt_m3 0.016 -0.009 -0.009 -0.009 -0.009
## 355 albumin_m1 ~ dhf 0.012 0.017 0.017 0.017 0.017
## 356 dhf ~~ lymph_m3 0.011 0.005 0.005 0.006 0.006
## 357 lymph_m1 ~~ platelets_m1 0.010 -0.004 -0.004 -0.006 -0.006
## 358 lymph_m3 ~ dhf 0.008 -0.005 -0.005 -0.005 -0.005
## 359 wbc_m1 ~ tourn_no_m1 0.006 -0.003 -0.003 -0.003 -0.003
## 360 max_hct_m1 ~ alt_m1 0.006 0.005 0.005 0.005 0.005
## 361 tourn_no_m3 ~ wbc_m1 0.006 -0.006 -0.006 -0.006 -0.006
## 362 lymph_m1 ~~ alt_m3 0.005 -0.003 -0.003 -0.003 -0.003
## 363 ast_m1 ~ lymph_m1 0.005 -0.002 -0.002 -0.002 -0.002
## 364 lymph_m1 ~ albumin_m3 0.004 -0.003 -0.003 -0.003 -0.003
## 365 wbc_m1 ~~ max_hct_m1 0.003 0.002 0.002 0.003 0.003
## 366 tourn_no_m1 ~ lymph_m1 0.003 -0.006 -0.006 -0.006 -0.006
## 367 wbc_m1 ~ max_hct_m1 0.002 -0.002 -0.002 -0.002 -0.002
## 368 platelets_m1 ~~ lymph_m3 0.002 -0.002 -0.002 -0.002 -0.002
## 369 ast_m1 ~~ wbc_m3 0.002 -0.001 -0.001 -0.002 -0.002
## 370 albumin_m1 ~~ wbc_m3 0.000 0.000 0.000 0.000 0.000
parameterestimates(fit,standardized = TRUE)
## lhs op rhs est se z pvalue ci.lower ci.upper
## 1 dhf ~ alt_m1 0.140 0.059 2.366 0.018 0.024 0.256
## 2 dhf ~ lymph_m1 -0.083 0.053 -1.551 0.121 -0.187 0.022
## 3 dhf ~ max_hct_m1 0.180 0.056 3.214 0.001 0.070 0.290
## 4 dhf ~ platelets_m1 -0.213 0.054 -3.952 0.000 -0.318 -0.107
## 5 dhf ~ tourn_no_m1 0.153 0.058 2.658 0.008 0.040 0.266
## 6 ast_m1 ~ ast_m3 0.793 0.113 7.033 0.000 0.572 1.014
## 7 ast_m1 ~ alt_m3 -0.253 0.061 -4.126 0.000 -0.374 -0.133
## 8 ast_m1 ~ platelets_m3 -0.037 0.026 -1.444 0.149 -0.088 0.013
## 9 alt_m1 ~ alt_m3 0.280 0.161 1.740 0.082 -0.035 0.595
## 10 alt_m1 ~ ast_m3 0.475 0.092 5.171 0.000 0.295 0.655
## 11 alt_m1 ~ albumin_m3 -0.040 0.036 -1.105 0.269 -0.110 0.031
## 12 wbc_m1 ~ wbc_m3 0.744 0.049 15.157 0.000 0.648 0.840
## 13 wbc_m1 ~ ast_m3 0.161 0.048 3.385 0.001 0.068 0.255
## 14 lymph_m1 ~ lymph_m3 0.390 0.065 6.040 0.000 0.263 0.516
## 15 lymph_m1 ~ wbc_m3 -0.143 0.047 -3.026 0.002 -0.235 -0.050
## 16 albumin_m1 ~ albumin_m3 0.526 0.055 9.501 0.000 0.417 0.634
## 17 albumin_m1 ~ platelets_m3 0.123 0.055 2.246 0.025 0.016 0.230
## 18 max_hct_m1 ~ max_hct_m3 0.509 0.060 8.541 0.000 0.392 0.625
## 19 max_hct_m1 ~ ast_m3 -0.092 0.095 -0.973 0.331 -0.279 0.094
## 20 platelets_m1 ~ platelets_m3 0.528 0.058 9.046 0.000 0.414 0.643
## 21 platelets_m1 ~ wbc_m3 0.265 0.068 3.900 0.000 0.132 0.398
## 22 tourn_no_m1 ~ tourn_no_m3 0.497 0.052 9.551 0.000 0.395 0.599
## 23 alt_m3 ~ age_t 0.127 0.040 3.135 0.002 0.048 0.206
## 24 wbc_m3 ~ age_t -0.186 0.053 -3.523 0.000 -0.289 -0.082
## 25 lymph_m3 ~ age_t -0.345 0.061 -5.639 0.000 -0.464 -0.225
## 26 max_hct_m3 ~ age_t 0.341 0.061 5.618 0.000 0.222 0.460
## 27 platelets_m3 ~ age_t -0.274 0.062 -4.422 0.000 -0.395 -0.152
## 28 tourn_no_m3 ~ age_t 0.116 0.062 1.866 0.062 -0.006 0.237
## 29 wbc_m1 ~ age_t -0.147 0.039 -3.749 0.000 -0.224 -0.070
## 30 max_hct_m1 ~ age_t 0.218 0.049 4.433 0.000 0.122 0.314
## 31 tourn_no_m1 ~ age_t 0.153 0.051 2.993 0.003 0.053 0.254
## 32 alt_m3 ~~ ast_m3 0.743 0.274 2.710 0.007 0.206 1.281
## 33 wbc_m3 ~~ lymph_m3 -0.329 0.049 -6.663 0.000 -0.426 -0.232
## 34 wbc_m3 ~~ platelets_m3 0.246 0.055 4.505 0.000 0.139 0.352
## 35 wbc_m3 ~~ tourn_no_m3 -0.137 0.049 -2.815 0.005 -0.233 -0.042
## 36 ast_m1 ~~ alt_m1 0.370 0.181 2.046 0.041 0.016 0.725
## 37 ast_m1 ~~ tourn_no_m1 0.020 0.019 1.020 0.308 -0.018 0.057
## 38 ast_m1 ~~ max_hct_m1 -0.028 0.023 -1.256 0.209 -0.073 0.016
## 39 wbc_m1 ~~ lymph_m1 -0.131 0.037 -3.497 0.000 -0.204 -0.057
## 40 lymph_m1 ~~ tourn_no_m1 -0.117 0.045 -2.622 0.009 -0.205 -0.030
## 41 max_hct_m1 ~~ platelets_m1 -0.120 0.040 -3.012 0.003 -0.198 -0.042
## 42 wbc_m1 ~~ platelets_m1 0.122 0.025 4.791 0.000 0.072 0.172
## 43 albumin_m1 ~~ platelets_m1 0.158 0.038 4.152 0.000 0.083 0.232
## 44 dhf ~~ dhf 0.784 0.075 10.395 0.000 0.636 0.932
## 45 ast_m1 ~~ ast_m1 0.574 0.381 1.508 0.132 -0.172 1.320
## 46 alt_m1 ~~ alt_m1 0.482 0.150 3.217 0.001 0.188 0.776
## 47 wbc_m1 ~~ wbc_m1 0.412 0.049 8.405 0.000 0.316 0.508
## 48 lymph_m1 ~~ lymph_m1 0.808 0.080 10.093 0.000 0.651 0.965
## 49 albumin_m1 ~~ albumin_m1 0.701 0.086 8.133 0.000 0.532 0.870
## 50 max_hct_m1 ~~ max_hct_m1 0.600 0.071 8.422 0.000 0.460 0.739
## 51 platelets_m1 ~~ platelets_m1 0.506 0.046 10.954 0.000 0.415 0.596
## 52 tourn_no_m1 ~~ tourn_no_m1 0.693 0.054 12.707 0.000 0.586 0.799
## 53 alt_m3 ~~ alt_m3 0.987 0.408 2.417 0.016 0.187 1.787
## 54 wbc_m3 ~~ wbc_m3 0.909 0.239 3.805 0.000 0.441 1.377
## 55 lymph_m3 ~~ lymph_m3 0.878 0.083 10.547 0.000 0.715 1.041
## 56 max_hct_m3 ~~ max_hct_m3 0.880 0.099 8.869 0.000 0.686 1.075
## 57 platelets_m3 ~~ platelets_m3 0.922 0.091 10.103 0.000 0.743 1.100
## 58 tourn_no_m3 ~~ tourn_no_m3 0.983 0.060 16.407 0.000 0.865 1.100
## 59 ast_m3 ~~ ast_m3 0.996 0.428 2.329 0.020 0.158 1.834
## 60 dhf ~~ ast_m1 0.012 0.025 0.489 0.625 -0.037 0.061
## 61 dhf ~~ wbc_m1 0.015 0.027 0.557 0.578 -0.038 0.068
## 62 dhf ~~ albumin_m1 -0.023 0.045 -0.518 0.605 -0.112 0.065
## 63 ast_m1 ~~ wbc_m1 -0.016 0.020 -0.773 0.439 -0.056 0.024
## 64 ast_m1 ~~ albumin_m1 0.043 0.053 0.811 0.417 -0.061 0.146
## 65 wbc_m1 ~~ albumin_m1 0.025 0.037 0.674 0.500 -0.048 0.098
## 66 albumin_m3 ~~ albumin_m3 0.996 0.102 9.727 0.000 0.795 1.197
## 67 albumin_m3 ~~ age_t 0.068 0.060 1.136 0.256 -0.050 0.186
## 68 age_t ~~ age_t 0.996 0.068 14.642 0.000 0.863 1.129
## std.lv std.all std.nox
## 1 0.140 0.144 0.144
## 2 -0.083 -0.086 -0.086
## 3 0.180 0.186 0.186
## 4 -0.213 -0.213 -0.213
## 5 0.153 0.157 0.157
## 6 0.793 0.805 0.805
## 7 -0.253 -0.258 -0.258
## 8 -0.037 -0.038 -0.038
## 9 0.280 0.282 0.282
## 10 0.475 0.478 0.478
## 11 -0.040 -0.040 -0.040
## 12 0.744 0.715 0.715
## 13 0.161 0.159 0.159
## 14 0.390 0.387 0.387
## 15 -0.143 -0.138 -0.138
## 16 0.526 0.528 0.529
## 17 0.123 0.123 0.123
## 18 0.509 0.511 0.511
## 19 -0.092 -0.093 -0.093
## 20 0.528 0.546 0.546
## 21 0.265 0.266 0.266
## 22 0.497 0.501 0.501
## 23 0.127 0.126 0.127
## 24 -0.186 -0.191 -0.191
## 25 -0.345 -0.345 -0.345
## 26 0.341 0.341 0.342
## 27 -0.274 -0.274 -0.274
## 28 0.116 0.116 0.116
## 29 -0.147 -0.145 -0.146
## 30 0.218 0.219 0.219
## 31 0.153 0.155 0.155
## 32 0.743 0.750 0.750
## 33 -0.329 -0.369 -0.369
## 34 0.246 0.268 0.268
## 35 -0.137 -0.145 -0.145
## 36 0.370 0.704 0.704
## 37 0.020 0.031 0.031
## 38 -0.028 -0.048 -0.048
## 39 -0.131 -0.226 -0.226
## 40 -0.117 -0.157 -0.157
## 41 -0.120 -0.218 -0.218
## 42 0.122 0.268 0.268
## 43 0.158 0.265 0.265
## 44 0.784 0.842 0.842
## 45 0.574 0.593 0.593
## 46 0.482 0.490 0.490
## 47 0.412 0.403 0.403
## 48 0.808 0.802 0.802
## 49 0.701 0.709 0.709
## 50 0.600 0.607 0.607
## 51 0.506 0.542 0.542
## 52 0.693 0.707 0.707
## 53 0.987 0.984 0.984
## 54 0.909 0.964 0.964
## 55 0.878 0.881 0.881
## 56 0.880 0.883 0.883
## 57 0.922 0.925 0.925
## 58 0.983 0.987 0.987
## 59 0.996 1.000 1.000
## 60 0.012 0.018 0.018
## 61 0.015 0.027 0.027
## 62 -0.023 -0.031 -0.031
## 63 -0.016 -0.032 -0.032
## 64 0.043 0.067 0.067
## 65 0.025 0.047 0.047
## 66 0.996 1.000 0.996
## 67 0.068 0.069 0.068
## 68 0.996 1.000 0.996
ly<-matrix(NA,18,2)
depVar='dhf'
med1=c('ast_m1','alt_m1','wbc_m1','lymph_m1','albumin_m1','max_hct_m1','platelets_m1','tourn_no_m1')
med2=c('ast_m3','alt_m3','wbc_m3','lymph_m3','albumin_m3','max_hct_m3','platelets_m3','tourn_no_m3')
indepVar='age_t'
labels=c()
labels[1]=depVar
ly[1,]=c(1,0)
y=1
for (x in c(1:length(med1))){
ly[y+x,]=c(0.6,(x/8*1.6-1))
labels[(x+y)]<-med1[x]
}
y=9
for (x in c(1:length(med2))){
ly[y+x,]=c(-1,(x/8*1.6-1))
labels[(x+y)]<-med2[x]
}
labels[18]=indepVar
ly[18,]=c(-0.5,1)
table2<-parameterEstimates(fit,standardized=TRUE)%>%as.data.frame()
table2<-table2[!table2$lhs==table2$rhs,]
b<-gettextf('%.3f \n p=%.3f', table2$std.all, digits=table2$pvalue)
fittitles<-fitmeasures(fit)[c('cfi.robust','tli.robust','rmsea.robust','rmsea.ci.lower.robust' , 'rmsea.ci.upper.robust')]%>%round(3)
semPaths(fit, layout=ly,
edgeLabels=b,
residuals=FALSE,
style='ram',
what='est',
whatLabels = "std",
cut=0.3,
sizeMan = 10, # Size of manifest variables
sizeMan2=3,edge.label.cex = 0.6,label.cex=1,
nCharNodes = 0,fade=TRUE,
mar = c(5,2,2,2))
text(0,-1.3,paste0(names(fittitles),': ',fittitles,collapse='; '),cex=1.5)
title('Adjusted Model')
Non-sense models also fits well
To illustrate how we must not adjust blindly following the modification indices, we present how non-sense models can also fit well.
Blind fit
The following is a blindly fitted model. Note how some paths does not make sense already because temporal issues. But its fit measure is very good.
library(lavaan)
Blind_model="
dhf~alt_m1+lymph_m1+max_hct_m1+platelets_m1
ast_m1~ast_m3
alt_m1~alt_m3
wbc_m1~wbc_m3
lymph_m1~lymph_m3
albumin_m1~albumin_m3
max_hct_m1~max_hct_m3
platelets_m1~platelets_m3
tourn_no_m1~tourn_no_m3
alt_m3~age_t
wbc_m3~age_t
lymph_m3~age_t
max_hct_m3~age_t
platelets_m3~age_t
tourn_no_m3~age_t
wbc_m3 ~ platelets_m1
platelets_m3 ~ wbc_m3
alt_m3 ~ ast_m3
alt_m1 ~ ast_m1
wbc_m3 ~ lymph_m3
tourn_no_m1 ~ dhf #OK
wbc_m1 ~ ast_m3
max_hct_m1 ~~ max_hct_m3
dhf ~~ tourn_no_m1
wbc_m1 ~ platelets_m1
albumin_m1 ~ platelets_m1
ast_m3 ~ wbc_m1
ast_m3 ~ albumin_m1
alt_m3 ~ ast_m1
lymph_m1 ~ wbc_m1
lymph_m3 ~ lymph_m1
"
Blind_fit=sem(model=Blind_model, data=data,std.ov=TRUE,estimator="MLR",fixed.x = FALSE)
fitmeasures(Blind_fit)[c('cfi.robust','tli.robust','rmsea.robust','rmsea.ci.lower.robust' , 'rmsea.ci.upper.robust')]
## cfi.robust tli.robust rmsea.robust
## 0.94808077 0.93312099 0.05542859
## rmsea.ci.lower.robust rmsea.ci.upper.robust
## 0.04328331 0.06727630
modificationindices(Blind_fit,standardized = TRUE)%>%arrange(-mi)
## lhs op rhs mi epc sepc.lv sepc.all sepc.nox
## 1 platelets_m1 ~ wbc_m3 13.673 0.359 0.359 0.349 0.349
## 2 albumin_m1 ~ alt_m1 12.984 0.228 0.228 0.231 0.231
## 3 albumin_m1 ~ ast_m1 12.384 0.211 0.211 0.213 0.213
## 4 tourn_no_m3 ~ wbc_m3 11.747 -0.222 -0.222 -0.215 -0.215
## 5 age_t ~ platelets_m3 10.989 -2.580 -2.580 -2.575 -2.575
## 6 platelets_m1 ~ max_hct_m1 10.812 -0.155 -0.155 -0.155 -0.155
## 7 max_hct_m1 ~ platelets_m1 10.811 -0.162 -0.162 -0.162 -0.162
## 8 age_t ~ wbc_m1 10.145 -0.299 -0.299 -0.289 -0.289
## 9 platelets_m3 ~ lymph_m3 10.053 -0.234 -0.234 -0.234 -0.234
## 10 max_hct_m1 ~~ platelets_m1 9.888 -0.115 -0.115 -0.148 -0.148
## 11 platelets_m1 ~ wbc_m1 9.309 0.262 0.262 0.254 0.254
## 12 max_hct_m3 ~ platelets_m1 9.010 -0.135 -0.135 -0.134 -0.134
## 13 albumin_m3 ~ platelets_m3 8.983 0.194 0.194 0.194 0.194
## 14 wbc_m1 ~ albumin_m3 8.717 -0.119 -0.119 -0.122 -0.123
## 15 ast_m1 ~~ albumin_m1 8.657 0.120 0.120 0.187 0.187
## 16 platelets_m3 ~ albumin_m3 8.656 0.169 0.169 0.169 0.169
## 17 tourn_no_m3 ~ dhf 8.490 0.186 0.186 0.183 0.183
## 18 platelets_m1 ~~ platelets_m3 8.403 -0.441 -0.441 -0.642 -0.642
## 19 platelets_m3 ~ platelets_m1 8.403 -0.783 -0.783 -0.784 -0.784
## 20 platelets_m3 ~ ast_m1 7.621 -0.164 -0.164 -0.164 -0.164
## 21 platelets_m1 ~~ wbc_m3 7.588 0.293 0.293 0.481 0.481
## 22 wbc_m3 ~ platelets_m3 7.588 -0.329 -0.329 -0.338 -0.338
## 23 wbc_m3 ~~ platelets_m3 7.588 -0.276 -0.276 -0.371 -0.371
## 24 alt_m1 ~ age_t 7.493 0.084 0.084 0.084 0.084
## 25 platelets_m1 ~ dhf 7.394 -0.177 -0.177 -0.174 -0.174
## 26 lymph_m1 ~ platelets_m1 6.729 0.200 0.200 0.200 0.200
## 27 lymph_m1 ~ tourn_no_m3 6.727 -0.171 -0.171 -0.171 -0.171
## 28 wbc_m3 ~ tourn_no_m1 6.431 -0.137 -0.137 -0.138 -0.138
## 29 lymph_m1 ~~ tourn_no_m3 6.387 -0.164 -0.164 -0.158 -0.158
## 30 ast_m1 ~ platelets_m3 6.138 -0.124 -0.124 -0.123 -0.123
## 31 platelets_m3 ~ wbc_m1 6.128 -0.261 -0.261 -0.253 -0.253
## 32 dhf ~ tourn_no_m1 5.988 0.290 0.290 0.287 0.287
## 33 dhf ~ tourn_no_m3 5.988 0.138 0.138 0.140 0.140
## 34 dhf ~~ tourn_no_m3 5.960 0.135 0.135 0.152 0.152
## 35 tourn_no_m3 ~ lymph_m3 5.856 0.160 0.160 0.159 0.159
## 36 wbc_m1 ~ lymph_m3 5.736 0.121 0.121 0.125 0.125
## 37 age_t ~ max_hct_m3 5.622 -2.289 -2.289 -2.289 -2.289
## 38 albumin_m3 ~ max_hct_m3 5.622 0.157 0.157 0.157 0.157
## 39 dhf ~ max_hct_m3 5.492 -0.133 -0.133 -0.135 -0.135
## 40 albumin_m3 ~ alt_m1 5.232 -0.155 -0.155 -0.155 -0.155
## 41 ast_m1 ~ platelets_m1 5.112 -0.113 -0.113 -0.113 -0.113
## 42 ast_m1 ~~ platelets_m3 5.106 -0.102 -0.102 -0.142 -0.142
## 43 wbc_m1 ~ alt_m3 5.020 -0.134 -0.134 -0.139 -0.139
## 44 max_hct_m1 ~ dhf 5.019 0.150 0.150 0.148 0.148
## 45 lymph_m3 ~ platelets_m1 4.886 -0.248 -0.248 -0.248 -0.248
## 46 platelets_m1 ~~ max_hct_m3 4.781 -0.072 -0.072 -0.103 -0.103
## 47 platelets_m1 ~ tourn_no_m3 4.738 -0.102 -0.102 -0.102 -0.102
## 48 max_hct_m3 ~ platelets_m3 4.659 -0.099 -0.099 -0.099 -0.099
## 49 lymph_m1 ~ platelets_m3 4.459 0.161 0.161 0.161 0.161
## 50 max_hct_m1 ~~ ast_m3 4.437 -0.103 -0.103 -0.099 -0.099
## 51 max_hct_m3 ~~ platelets_m3 4.410 -0.085 -0.085 -0.099 -0.099
## 52 lymph_m1 ~ tourn_no_m1 4.226 -0.148 -0.148 -0.144 -0.144
## 53 albumin_m1 ~ ast_m3 4.218 0.187 0.187 0.190 0.190
## 54 wbc_m1 ~~ alt_m3 4.195 -0.052 -0.052 -0.129 -0.129
## 55 platelets_m3 ~ alt_m1 4.162 -0.122 -0.122 -0.123 -0.123
## 56 tourn_no_m3 ~ platelets_m1 4.078 -0.127 -0.127 -0.127 -0.127
## 57 wbc_m1 ~ age_t 4.058 -0.082 -0.082 -0.084 -0.085
## 58 platelets_m1 ~~ tourn_no_m3 3.934 -0.092 -0.092 -0.124 -0.124
## 59 tourn_no_m3 ~ ast_m3 3.929 0.123 0.123 0.123 0.123
## 60 age_t ~ platelets_m1 3.917 -0.165 -0.165 -0.165 -0.165
## 61 platelets_m3 ~ max_hct_m1 3.874 -0.124 -0.124 -0.124 -0.124
## 62 lymph_m3 ~ platelets_m3 3.709 -0.236 -0.236 -0.236 -0.236
## 63 dhf ~~ max_hct_m1 3.707 0.112 0.112 0.120 0.120
## 64 wbc_m3 ~~ tourn_no_m3 3.691 -0.096 -0.096 -0.120 -0.120
## 65 wbc_m3 ~ tourn_no_m3 3.691 -0.098 -0.098 -0.101 -0.101
## 66 max_hct_m1 ~~ alt_m3 3.640 0.059 0.059 0.090 0.090
## 67 max_hct_m1 ~ ast_m1 3.602 -0.092 -0.092 -0.092 -0.092
## 68 lymph_m1 ~~ platelets_m3 3.472 0.123 0.123 0.128 0.128
## 69 tourn_no_m3 ~ tourn_no_m1 3.469 0.423 0.423 0.412 0.412
## 70 platelets_m1 ~ age_t 3.423 -0.090 -0.090 -0.090 -0.091
## 71 dhf ~ wbc_m3 3.420 -0.099 -0.099 -0.098 -0.098
## 72 tourn_no_m3 ~ wbc_m1 3.315 -0.118 -0.118 -0.114 -0.114
## 73 wbc_m1 ~~ ast_m3 3.279 -0.314 -0.314 -0.493 -0.493
## 74 wbc_m1 ~ albumin_m1 3.279 -0.078 -0.078 -0.080 -0.080
## 75 lymph_m3 ~~ platelets_m3 3.263 -0.193 -0.193 -0.131 -0.131
## 76 dhf ~~ wbc_m3 3.251 -0.068 -0.068 -0.093 -0.093
## 77 dhf ~ ast_m3 3.110 0.115 0.115 0.117 0.117
## 78 alt_m3 ~ max_hct_m1 3.056 0.077 0.077 0.076 0.076
## 79 max_hct_m1 ~ lymph_m3 3.030 -0.090 -0.090 -0.090 -0.090
## 80 lymph_m3 ~ wbc_m3 3.020 -0.367 -0.367 -0.358 -0.358
## 81 wbc_m1 ~~ lymph_m1 3.012 -0.099 -0.099 -0.148 -0.148
## 82 max_hct_m1 ~ ast_m3 2.981 -0.084 -0.084 -0.084 -0.084
## 83 age_t ~ wbc_m3 2.918 -0.410 -0.410 -0.398 -0.398
## 84 platelets_m3 ~ albumin_m1 2.851 0.116 0.116 0.115 0.115
## 85 albumin_m1 ~ wbc_m3 2.842 -0.096 -0.096 -0.094 -0.094
## 86 albumin_m3 ~ tourn_no_m1 2.830 -0.110 -0.110 -0.107 -0.107
## 87 platelets_m3 ~ max_hct_m3 2.706 -0.100 -0.100 -0.100 -0.100
## 88 albumin_m1 ~~ ast_m3 2.678 0.150 0.150 0.184 0.184
## 89 alt_m1 ~ max_hct_m1 2.678 0.050 0.050 0.050 0.050
## 90 ast_m3 ~ albumin_m3 2.628 -0.119 -0.119 -0.119 -0.119
## 91 alt_m1 ~ wbc_m3 2.611 -0.052 -0.052 -0.050 -0.050
## 92 tourn_no_m1 ~~ wbc_m3 2.610 -0.065 -0.065 -0.083 -0.083
## 93 ast_m1 ~ lymph_m3 2.607 -0.080 -0.080 -0.080 -0.080
## 94 dhf ~~ platelets_m3 2.554 0.084 0.084 0.102 0.102
## 95 platelets_m3 ~ ast_m3 2.515 -0.099 -0.099 -0.100 -0.100
## 96 tourn_no_m3 ~ albumin_m1 2.508 -0.099 -0.099 -0.098 -0.098
## 97 dhf ~~ max_hct_m3 2.490 -0.105 -0.105 -0.125 -0.125
## 98 ast_m3 ~ age_t 2.478 -0.101 -0.101 -0.100 -0.101
## 99 max_hct_m3 ~ lymph_m3 2.476 -0.074 -0.074 -0.074 -0.074
## 100 alt_m3 ~ lymph_m3 2.359 -0.066 -0.066 -0.065 -0.065
## 101 wbc_m1 ~~ platelets_m3 2.340 -0.070 -0.070 -0.120 -0.120
## 102 ast_m1 ~ albumin_m1 2.333 0.079 0.079 0.078 0.078
## 103 lymph_m1 ~~ platelets_m1 2.311 0.081 0.081 0.102 0.102
## 104 platelets_m3 ~~ ast_m3 2.310 -0.092 -0.092 -0.100 -0.100
## 105 albumin_m3 ~ alt_m3 2.286 -0.104 -0.104 -0.105 -0.105
## 106 alt_m3 ~~ tourn_no_m3 2.267 -0.060 -0.060 -0.094 -0.094
## 107 alt_m3 ~ tourn_no_m3 2.267 -0.061 -0.061 -0.060 -0.060
## 108 albumin_m3 ~ lymph_m3 2.253 -0.100 -0.100 -0.099 -0.099
## 109 albumin_m3 ~ platelets_m1 2.236 0.095 0.095 0.094 0.094
## 110 lymph_m1 ~~ max_hct_m1 2.225 0.076 0.076 0.070 0.070
## 111 platelets_m1 ~ tourn_no_m1 2.175 -0.084 -0.084 -0.082 -0.082
## 112 lymph_m3 ~ tourn_no_m3 2.163 0.149 0.149 0.149 0.149
## 113 lymph_m3 ~~ tourn_no_m3 2.163 0.146 0.146 0.092 0.092
## 114 lymph_m3 ~~ max_hct_m3 2.152 -0.104 -0.104 -0.069 -0.069
## 115 ast_m3 ~ max_hct_m1 2.149 -0.092 -0.092 -0.092 -0.092
## 116 albumin_m1 ~ age_t 2.143 0.076 0.076 0.076 0.077
## 117 max_hct_m1 ~ platelets_m3 2.065 -0.073 -0.073 -0.073 -0.073
## 118 alt_m3 ~~ max_hct_m3 2.013 0.040 0.040 0.067 0.067
## 119 ast_m1 ~ wbc_m1 2.004 -0.072 -0.072 -0.070 -0.070
## 120 ast_m3 ~ alt_m1 1.956 -0.244 -0.244 -0.244 -0.244
## 121 alt_m1 ~ wbc_m1 1.942 -0.044 -0.044 -0.042 -0.042
## 122 age_t ~ tourn_no_m1 1.919 0.119 0.119 0.116 0.116
## 123 ast_m3 ~ wbc_m3 1.903 0.293 0.293 0.284 0.284
## 124 albumin_m3 ~ ast_m1 1.889 -0.091 -0.091 -0.091 -0.091
## 125 platelets_m1 ~~ lymph_m3 1.849 -0.106 -0.106 -0.088 -0.088
## 126 ast_m3 ~ alt_m3 1.780 -0.313 -0.313 -0.315 -0.315
## 127 albumin_m1 ~ alt_m3 1.742 0.086 0.086 0.087 0.087
## 128 lymph_m3 ~ max_hct_m3 1.734 -0.141 -0.141 -0.141 -0.141
## 129 alt_m1 ~~ lymph_m1 1.730 -0.042 -0.042 -0.082 -0.082
## 130 max_hct_m1 ~~ platelets_m3 1.714 -0.058 -0.058 -0.061 -0.061
## 131 age_t ~ alt_m3 1.699 -0.111 -0.111 -0.112 -0.112
## 132 alt_m1 ~ max_hct_m3 1.692 0.040 0.040 0.040 0.040
## 133 lymph_m3 ~ max_hct_m1 1.681 -0.143 -0.143 -0.143 -0.143
## 134 tourn_no_m1 ~ lymph_m1 1.659 -0.084 -0.084 -0.087 -0.087
## 135 wbc_m1 ~~ max_hct_m1 1.659 0.040 0.040 0.060 0.060
## 136 albumin_m3 ~ ast_m3 1.649 -0.095 -0.095 -0.095 -0.095
## 137 albumin_m1 ~~ max_hct_m1 1.641 0.051 0.051 0.060 0.060
## 138 alt_m1 ~ albumin_m3 1.588 -0.039 -0.039 -0.038 -0.038
## 139 dhf ~~ ast_m3 1.572 0.077 0.077 0.086 0.086
## 140 max_hct_m1 ~ albumin_m3 1.570 -0.061 -0.061 -0.061 -0.061
## 141 albumin_m1 ~~ lymph_m3 1.510 0.100 0.100 0.077 0.077
## 142 tourn_no_m1 ~ albumin_m3 1.457 -0.060 -0.060 -0.061 -0.061
## 143 wbc_m3 ~ dhf 1.453 -0.066 -0.066 -0.067 -0.067
## 144 wbc_m3 ~ wbc_m1 1.449 0.191 0.191 0.190 0.190
## 145 dhf ~~ alt_m3 1.446 -0.037 -0.037 -0.064 -0.064
## 146 max_hct_m1 ~ wbc_m1 1.439 -0.061 -0.061 -0.059 -0.059
## 147 alt_m1 ~ platelets_m1 1.436 -0.037 -0.037 -0.037 -0.037
## 148 lymph_m3 ~ dhf 1.423 0.163 0.163 0.161 0.161
## 149 alt_m1 ~~ albumin_m1 1.374 0.029 0.029 0.074 0.074
## 150 alt_m1 ~ platelets_m3 1.364 -0.036 -0.036 -0.036 -0.036
## 151 age_t ~ ast_m3 1.361 -0.076 -0.076 -0.076 -0.076
## 152 alt_m1 ~~ ast_m3 1.348 -0.057 -0.057 -0.116 -0.116
## 153 dhf ~ platelets_m3 1.341 0.071 0.071 0.072 0.072
## 154 dhf ~~ platelets_m1 1.341 -0.064 -0.064 -0.094 -0.094
## 155 max_hct_m3 ~ alt_m3 1.311 0.051 0.051 0.051 0.051
## 156 age_t ~ alt_m1 1.301 0.076 0.076 0.076 0.076
## 157 lymph_m3 ~ wbc_m1 1.293 -0.187 -0.187 -0.181 -0.181
## 158 lymph_m1 ~~ lymph_m3 1.293 -0.574 -0.574 -0.341 -0.341
## 159 lymph_m1 ~ age_t 1.292 -0.138 -0.138 -0.138 -0.138
## 160 ast_m3 ~ max_hct_m3 1.292 0.071 0.071 0.071 0.071
## 161 tourn_no_m3 ~~ ast_m3 1.287 0.070 0.070 0.071 0.071
## 162 albumin_m3 ~ albumin_m1 1.243 0.292 0.292 0.289 0.289
## 163 tourn_no_m3 ~ ast_m1 1.234 0.069 0.069 0.069 0.069
## 164 dhf ~~ alt_m1 1.234 -0.029 -0.029 -0.065 -0.065
## 165 lymph_m1 ~ max_hct_m3 1.232 -0.076 -0.076 -0.076 -0.076
## 166 dhf ~ wbc_m1 1.207 -0.061 -0.061 -0.060 -0.060
## 167 alt_m3 ~~ lymph_m3 1.204 -0.070 -0.070 -0.069 -0.069
## 168 albumin_m3 ~ wbc_m1 1.203 -0.072 -0.072 -0.070 -0.070
## 169 lymph_m1 ~ wbc_m3 1.199 0.133 0.133 0.129 0.129
## 170 wbc_m1 ~ alt_m1 1.196 -0.062 -0.062 -0.064 -0.064
## 171 alt_m3 ~ albumin_m3 1.171 -0.044 -0.044 -0.043 -0.043
## 172 albumin_m1 ~ wbc_m1 1.164 -0.067 -0.067 -0.065 -0.065
## 173 ast_m1 ~~ max_hct_m1 1.133 -0.041 -0.041 -0.050 -0.050
## 174 tourn_no_m3 ~ alt_m1 1.132 0.066 0.066 0.066 0.066
## 175 tourn_no_m1 ~~ lymph_m3 1.112 -0.097 -0.097 -0.063 -0.063
## 176 albumin_m1 ~~ wbc_m3 1.101 -0.043 -0.043 -0.066 -0.066
## 177 albumin_m3 ~ wbc_m3 1.099 0.068 0.068 0.066 0.066
## 178 platelets_m1 ~ lymph_m3 1.099 -0.053 -0.053 -0.053 -0.053
## 179 wbc_m1 ~~ wbc_m3 1.089 0.075 0.075 0.146 0.146
## 180 max_hct_m1 ~ wbc_m3 1.084 -0.053 -0.053 -0.051 -0.051
## 181 max_hct_m1 ~~ wbc_m3 1.076 -0.041 -0.041 -0.049 -0.049
## 182 ast_m1 ~ age_t 1.065 0.051 0.051 0.051 0.051
## 183 ast_m1 ~ alt_m3 1.065 0.373 0.373 0.376 0.376
## 184 albumin_m1 ~~ tourn_no_m3 1.061 -0.052 -0.052 -0.064 -0.064
## 185 ast_m3 ~ platelets_m3 1.024 -0.073 -0.073 -0.073 -0.073
## 186 age_t ~ albumin_m1 1.017 0.076 0.076 0.076 0.076
## 187 tourn_no_m1 ~ platelets_m1 0.985 0.076 0.076 0.078 0.078
## 188 tourn_no_m1 ~ max_hct_m3 0.976 -0.055 -0.055 -0.056 -0.056
## 189 wbc_m3 ~ max_hct_m1 0.974 -0.055 -0.055 -0.057 -0.057
## 190 tourn_no_m1 ~ lymph_m3 0.961 -0.051 -0.051 -0.053 -0.053
## 191 lymph_m1 ~ albumin_m3 0.960 0.064 0.064 0.064 0.064
## 192 wbc_m3 ~ albumin_m1 0.950 -0.052 -0.052 -0.053 -0.053
## 193 max_hct_m3 ~ albumin_m3 0.923 0.043 0.043 0.043 0.043
## 194 max_hct_m1 ~ alt_m1 0.921 -0.047 -0.047 -0.047 -0.047
## 195 tourn_no_m1 ~~ max_hct_m3 0.920 -0.042 -0.042 -0.047 -0.047
## 196 albumin_m1 ~ max_hct_m1 0.917 0.049 0.049 0.049 0.049
## 197 ast_m1 ~ alt_m1 0.915 0.221 0.221 0.222 0.222
## 198 tourn_no_m1 ~ wbc_m3 0.912 -0.051 -0.051 -0.051 -0.051
## 199 tourn_no_m3 ~ max_hct_m3 0.910 0.063 0.063 0.063 0.063
## 200 ast_m3 ~ tourn_no_m3 0.900 0.059 0.059 0.059 0.059
## 201 lymph_m1 ~ dhf 0.873 -0.070 -0.070 -0.069 -0.069
## 202 dhf ~ ast_m1 0.871 0.068 0.068 0.069 0.069
## 203 platelets_m1 ~ alt_m1 0.863 -0.047 -0.047 -0.047 -0.047
## 204 lymph_m3 ~ ast_m1 0.853 -0.096 -0.096 -0.096 -0.096
## 205 wbc_m1 ~~ max_hct_m3 0.835 0.026 0.026 0.043 0.043
## 206 ast_m1 ~~ lymph_m3 0.832 -0.072 -0.072 -0.057 -0.057
## 207 alt_m3 ~ wbc_m1 0.826 -0.038 -0.038 -0.036 -0.036
## 208 ast_m1 ~~ platelets_m1 0.818 -0.034 -0.034 -0.057 -0.057
## 209 alt_m3 ~ tourn_no_m1 0.773 -0.038 -0.038 -0.036 -0.036
## 210 max_hct_m3 ~ lymph_m1 0.769 -0.040 -0.040 -0.040 -0.040
## 211 tourn_no_m1 ~ age_t 0.767 0.049 0.049 0.050 0.050
## 212 tourn_no_m1 ~~ tourn_no_m3 0.767 -0.416 -0.416 -0.435 -0.435
## 213 wbc_m1 ~~ platelets_m1 0.759 0.042 0.042 0.087 0.087
## 214 wbc_m1 ~ platelets_m3 0.759 -0.047 -0.047 -0.048 -0.048
## 215 albumin_m1 ~ tourn_no_m3 0.735 -0.044 -0.044 -0.044 -0.044
## 216 max_hct_m3 ~ wbc_m3 0.730 -0.039 -0.039 -0.038 -0.038
## 217 tourn_no_m1 ~ ast_m3 0.703 0.048 0.048 0.050 0.050
## 218 lymph_m1 ~ albumin_m1 0.699 0.055 0.055 0.055 0.055
## 219 tourn_no_m1 ~ wbc_m1 0.698 -0.045 -0.045 -0.045 -0.045
## 220 wbc_m1 ~~ lymph_m3 0.683 0.063 0.063 0.062 0.062
## 221 wbc_m3 ~~ max_hct_m3 0.681 -0.030 -0.030 -0.039 -0.039
## 222 tourn_no_m3 ~ platelets_m3 0.669 -0.053 -0.053 -0.053 -0.053
## 223 lymph_m3 ~ alt_m3 0.662 -0.086 -0.086 -0.087 -0.087
## 224 ast_m1 ~ wbc_m3 0.661 -0.042 -0.042 -0.041 -0.041
## 225 albumin_m1 ~ max_hct_m3 0.651 -0.041 -0.041 -0.042 -0.042
## 226 tourn_no_m1 ~~ platelets_m3 0.630 0.040 0.040 0.045 0.045
## 227 max_hct_m1 ~~ tourn_no_m3 0.628 -0.038 -0.038 -0.037 -0.037
## 228 max_hct_m1 ~ tourn_no_m3 0.628 -0.039 -0.039 -0.039 -0.039
## 229 lymph_m3 ~ albumin_m3 0.626 -0.080 -0.080 -0.080 -0.080
## 230 wbc_m1 ~~ tourn_no_m3 0.605 0.031 0.031 0.049 0.049
## 231 wbc_m1 ~~ tourn_no_m1 0.586 -0.024 -0.024 -0.039 -0.039
## 232 ast_m1 ~~ wbc_m3 0.584 -0.031 -0.031 -0.048 -0.048
## 233 alt_m1 ~~ lymph_m3 0.584 0.037 0.037 0.048 0.048
## 234 albumin_m1 ~~ platelets_m1 0.580 0.046 0.046 0.075 0.075
## 235 albumin_m1 ~ platelets_m3 0.580 -0.052 -0.052 -0.052 -0.052
## 236 platelets_m1 ~ max_hct_m3 0.573 -0.036 -0.036 -0.036 -0.036
## 237 alt_m3 ~ dhf 0.560 -0.032 -0.032 -0.031 -0.031
## 238 max_hct_m3 ~ dhf 0.543 0.049 0.049 0.048 0.048
## 239 ast_m1 ~ albumin_m3 0.531 -0.036 -0.036 -0.036 -0.036
## 240 max_hct_m1 ~~ lymph_m3 0.522 -0.056 -0.056 -0.034 -0.034
## 241 platelets_m1 ~~ tourn_no_m1 0.515 0.032 0.032 0.045 0.045
## 242 alt_m3 ~ platelets_m3 0.509 0.030 0.030 0.030 0.030
## 243 alt_m1 ~ ast_m3 0.492 -0.039 -0.039 -0.039 -0.039
## 244 ast_m1 ~~ alt_m1 0.492 0.040 0.040 0.104 0.104
## 245 tourn_no_m1 ~ albumin_m1 0.478 -0.035 -0.035 -0.036 -0.036
## 246 albumin_m1 ~~ alt_m3 0.469 0.023 0.023 0.044 0.044
## 247 lymph_m1 ~~ alt_m3 0.469 0.029 0.029 0.043 0.043
## 248 platelets_m1 ~ ast_m1 0.467 -0.034 -0.034 -0.034 -0.034
## 249 alt_m1 ~ lymph_m1 0.440 -0.020 -0.020 -0.020 -0.020
## 250 max_hct_m3 ~ wbc_m1 0.422 -0.030 -0.030 -0.029 -0.029
## 251 alt_m3 ~~ ast_m3 0.413 -0.073 -0.073 -0.114 -0.114
## 252 alt_m3 ~~ platelets_m3 0.398 0.023 0.023 0.040 0.040
## 253 ast_m3 ~ tourn_no_m1 0.394 0.045 0.045 0.044 0.044
## 254 alt_m3 ~ wbc_m3 0.381 0.026 0.026 0.025 0.025
## 255 wbc_m3 ~~ lymph_m3 0.376 -0.106 -0.106 -0.081 -0.081
## 256 wbc_m3 ~ lymph_m1 0.376 -0.043 -0.043 -0.044 -0.044
## 257 platelets_m1 ~~ ast_m3 0.372 0.031 0.031 0.042 0.042
## 258 alt_m1 ~~ platelets_m1 0.365 -0.014 -0.014 -0.038 -0.038
## 259 dhf ~~ lymph_m1 0.365 -0.034 -0.034 -0.036 -0.036
## 260 wbc_m1 ~ max_hct_m3 0.350 -0.024 -0.024 -0.024 -0.024
## 261 platelets_m1 ~ albumin_m3 0.342 -0.027 -0.027 -0.027 -0.027
## 262 alt_m1 ~~ tourn_no_m1 0.340 -0.015 -0.015 -0.032 -0.032
## 263 alt_m1 ~ tourn_no_m3 0.337 0.018 0.018 0.018 0.018
## 264 alt_m1 ~~ max_hct_m3 0.327 0.012 0.012 0.027 0.027
## 265 platelets_m1 ~~ alt_m3 0.325 -0.017 -0.017 -0.036 -0.036
## 266 lymph_m1 ~ alt_m1 0.323 -0.038 -0.038 -0.038 -0.038
## 267 ast_m3 ~ dhf 0.322 0.044 0.044 0.043 0.043
## 268 max_hct_m3 ~ alt_m1 0.320 0.025 0.025 0.025 0.025
## 269 ast_m1 ~~ max_hct_m3 0.304 -0.019 -0.019 -0.026 -0.026
## 270 dhf ~~ albumin_m1 0.301 -0.021 -0.021 -0.028 -0.028
## 271 albumin_m1 ~ lymph_m1 0.300 0.028 0.028 0.028 0.028
## 272 lymph_m3 ~ alt_m1 0.298 -0.057 -0.057 -0.057 -0.057
## 273 wbc_m1 ~ tourn_no_m3 0.298 0.022 0.022 0.022 0.022
## 274 tourn_no_m3 ~ alt_m3 0.290 0.034 0.034 0.034 0.034
## 275 ast_m1 ~ max_hct_m3 0.290 0.027 0.027 0.027 0.027
## 276 albumin_m3 ~ dhf 0.281 0.034 0.034 0.034 0.034
## 277 tourn_no_m1 ~ alt_m3 0.278 0.030 0.030 0.031 0.031
## 278 ast_m1 ~ dhf 0.271 0.028 0.028 0.028 0.028
## 279 lymph_m1 ~ max_hct_m1 0.266 0.036 0.036 0.036 0.036
## 280 albumin_m1 ~ lymph_m3 0.266 0.026 0.026 0.027 0.027
## 281 ast_m1 ~~ lymph_m1 0.264 0.027 0.027 0.032 0.032
## 282 tourn_no_m3 ~ albumin_m3 0.261 -0.032 -0.032 -0.032 -0.032
## 283 albumin_m3 ~ tourn_no_m3 0.261 -0.032 -0.032 -0.032 -0.032
## 284 age_t ~ tourn_no_m3 0.261 0.467 0.467 0.467 0.467
## 285 platelets_m3 ~ dhf 0.254 0.035 0.035 0.035 0.035
## 286 wbc_m1 ~ ast_m1 0.244 -0.025 -0.025 -0.026 -0.026
## 287 ast_m1 ~~ wbc_m1 0.244 -0.016 -0.016 -0.031 -0.031
## 288 wbc_m1 ~ lymph_m1 0.240 0.022 0.022 0.023 0.023
## 289 lymph_m3 ~~ ast_m3 0.225 -0.052 -0.052 -0.032 -0.032
## 290 ast_m1 ~ lymph_m1 0.224 -0.023 -0.023 -0.023 -0.023
## 291 wbc_m3 ~ ast_m1 0.218 -0.027 -0.027 -0.027 -0.027
## 292 max_hct_m1 ~ lymph_m1 0.218 0.024 0.024 0.024 0.024
## 293 wbc_m1 ~ tourn_no_m1 0.202 -0.019 -0.019 -0.019 -0.019
## 294 wbc_m3 ~ ast_m3 0.189 0.032 0.032 0.033 0.033
## 295 lymph_m1 ~ ast_m3 0.183 -0.029 -0.029 -0.029 -0.029
## 296 platelets_m1 ~ alt_m3 0.175 -0.021 -0.021 -0.021 -0.021
## 297 lymph_m1 ~~ wbc_m3 0.171 -0.031 -0.031 -0.037 -0.037
## 298 alt_m1 ~~ max_hct_m1 0.168 0.010 0.010 0.019 0.019
## 299 wbc_m3 ~ alt_m1 0.163 -0.024 -0.024 -0.025 -0.025
## 300 tourn_no_m1 ~~ ast_m3 0.155 0.022 0.022 0.023 0.023
## 301 lymph_m1 ~~ tourn_no_m1 0.149 -0.021 -0.021 -0.021 -0.021
## 302 alt_m1 ~~ wbc_m3 0.140 -0.009 -0.009 -0.024 -0.024
## 303 tourn_no_m1 ~ platelets_m3 0.134 0.021 0.021 0.022 0.022
## 304 max_hct_m3 ~ albumin_m1 0.133 -0.016 -0.016 -0.016 -0.016
## 305 max_hct_m1 ~ albumin_m1 0.130 -0.018 -0.018 -0.018 -0.018
## 306 dhf ~ albumin_m3 0.126 0.016 0.016 0.017 0.017
## 307 tourn_no_m1 ~~ alt_m3 0.125 -0.011 -0.011 -0.018 -0.018
## 308 platelets_m3 ~ alt_m3 0.121 -0.021 -0.021 -0.021 -0.021
## 309 alt_m3 ~ lymph_m1 0.105 -0.013 -0.013 -0.013 -0.013
## 310 max_hct_m3 ~ ast_m1 0.100 -0.014 -0.014 -0.014 -0.014
## 311 lymph_m3 ~ ast_m3 0.098 -0.034 -0.034 -0.034 -0.034
## 312 dhf ~~ lymph_m3 0.097 0.040 0.040 0.028 0.028
## 313 ast_m1 ~ max_hct_m1 0.094 -0.015 -0.015 -0.015 -0.015
## 314 max_hct_m1 ~ tourn_no_m1 0.091 0.018 0.018 0.017 0.017
## 315 ast_m1 ~~ tourn_no_m1 0.091 -0.012 -0.012 -0.016 -0.016
## 316 dhf ~ alt_m3 0.091 0.018 0.018 0.018 0.018
## 317 lymph_m1 ~~ max_hct_m3 0.089 0.014 0.014 0.014 0.014
## 318 max_hct_m1 ~~ tourn_no_m1 0.087 0.014 0.014 0.014 0.014
## 319 wbc_m3 ~ alt_m3 0.079 0.017 0.017 0.018 0.018
## 320 dhf ~ albumin_m1 0.076 -0.013 -0.013 -0.013 -0.013
## 321 alt_m1 ~ tourn_no_m1 0.075 0.009 0.009 0.009 0.009
## 322 alt_m1 ~~ tourn_no_m3 0.073 0.008 0.008 0.017 0.017
## 323 dhf ~ lymph_m3 0.070 0.014 0.014 0.014 0.014
## 324 ast_m3 ~ lymph_m3 0.068 0.018 0.018 0.017 0.017
## 325 alt_m1 ~ lymph_m3 0.063 0.008 0.008 0.008 0.008
## 326 tourn_no_m1 ~ ast_m1 0.063 0.015 0.015 0.015 0.015
## 327 alt_m1 ~~ platelets_m3 0.063 -0.007 -0.007 -0.016 -0.016
## 328 albumin_m1 ~~ tourn_no_m1 0.059 -0.010 -0.010 -0.012 -0.012
## 329 wbc_m3 ~~ ast_m3 0.058 0.018 0.018 0.022 0.022
## 330 lymph_m1 ~~ albumin_m1 0.056 -0.013 -0.013 -0.015 -0.015
## 331 dhf ~~ ast_m1 0.056 -0.010 -0.010 -0.013 -0.013
## 332 albumin_m1 ~ tourn_no_m1 0.052 -0.012 -0.012 -0.012 -0.012
## 333 alt_m1 ~~ wbc_m1 0.052 0.004 0.004 0.014 0.014
## 334 wbc_m1 ~ max_hct_m1 0.051 0.009 0.009 0.009 0.009
## 335 lymph_m1 ~~ ast_m3 0.049 -0.016 -0.016 -0.015 -0.015
## 336 wbc_m1 ~~ albumin_m1 0.048 -0.007 -0.007 -0.014 -0.014
## 337 alt_m3 ~ max_hct_m3 0.047 0.009 0.009 0.009 0.009
## 338 platelets_m3 ~ tourn_no_m3 0.045 -0.012 -0.012 -0.012 -0.012
## 339 platelets_m3 ~~ tourn_no_m3 0.045 -0.012 -0.012 -0.013 -0.013
## 340 dhf ~~ wbc_m1 0.043 -0.006 -0.006 -0.011 -0.011
## 341 max_hct_m3 ~ tourn_no_m3 0.039 0.009 0.009 0.009 0.009
## 342 max_hct_m3 ~~ tourn_no_m3 0.039 0.009 0.009 0.009 0.009
## 343 max_hct_m3 ~ ast_m3 0.038 0.009 0.009 0.009 0.009
## 344 age_t ~ lymph_m1 0.038 0.040 0.040 0.040 0.040
## 345 albumin_m1 ~~ max_hct_m3 0.038 -0.007 -0.007 -0.009 -0.009
## 346 tourn_no_m3 ~ max_hct_m1 0.036 -0.013 -0.013 -0.013 -0.013
## 347 wbc_m3 ~ max_hct_m3 0.036 -0.010 -0.010 -0.011 -0.011
## 348 platelets_m3 ~ tourn_no_m1 0.035 0.012 0.012 0.012 0.012
## 349 age_t ~ ast_m1 0.032 0.011 0.011 0.011 0.011
## 350 ast_m3 ~ platelets_m1 0.031 -0.014 -0.014 -0.014 -0.014
## 351 alt_m3 ~~ wbc_m3 0.029 -0.006 -0.006 -0.011 -0.011
## 352 wbc_m3 ~ albumin_m3 0.027 -0.008 -0.008 -0.009 -0.009
## 353 albumin_m1 ~ dhf 0.027 0.009 0.009 0.009 0.009
## 354 lymph_m1 ~ ast_m1 0.025 0.011 0.011 0.011 0.011
## 355 albumin_m3 ~ max_hct_m1 0.021 0.010 0.010 0.010 0.010
## 356 age_t ~ max_hct_m1 0.021 -0.143 -0.143 -0.143 -0.143
## 357 ast_m1 ~ tourn_no_m1 0.019 0.007 0.007 0.007 0.007
## 358 albumin_m3 ~ lymph_m1 0.018 0.009 0.009 0.009 0.009
## 359 lymph_m3 ~ albumin_m1 0.017 0.013 0.013 0.013 0.013
## 360 lymph_m3 ~ tourn_no_m1 0.017 0.016 0.016 0.015 0.015
## 361 ast_m1 ~~ tourn_no_m3 0.016 -0.006 -0.006 -0.008 -0.008
## 362 platelets_m1 ~ albumin_m1 0.016 0.008 0.008 0.008 0.008
## 363 wbc_m1 ~ dhf 0.014 0.005 0.005 0.005 0.005
## 364 platelets_m1 ~ ast_m3 0.013 0.006 0.006 0.006 0.006
## 365 dhf ~ age_t 0.010 0.005 0.005 0.005 0.005
## 366 max_hct_m1 ~ alt_m3 0.009 0.005 0.005 0.005 0.005
## 367 tourn_no_m3 ~ lymph_m1 0.009 0.006 0.006 0.006 0.006
## 368 tourn_no_m1 ~ alt_m1 0.008 0.006 0.006 0.006 0.006
## 369 tourn_no_m1 ~ max_hct_m1 0.007 -0.006 -0.006 -0.006 -0.006
## 370 alt_m3 ~ alt_m1 0.006 -0.009 -0.009 -0.009 -0.009
## 371 alt_m1 ~~ alt_m3 0.006 -0.002 -0.002 -0.007 -0.007
## 372 age_t ~ lymph_m3 0.006 0.015 0.015 0.015 0.015
## 373 max_hct_m3 ~ tourn_no_m1 0.006 0.004 0.004 0.004 0.004
## 374 albumin_m1 ~~ platelets_m3 0.004 0.004 0.004 0.005 0.005
## 375 max_hct_m3 ~~ ast_m3 0.003 -0.002 -0.002 -0.003 -0.003
## 376 platelets_m3 ~ lymph_m1 0.002 -0.003 -0.003 -0.003 -0.003
## 377 alt_m1 ~ dhf 0.002 -0.002 -0.002 -0.001 -0.001
## 378 lymph_m1 ~ alt_m3 0.001 -0.002 -0.002 -0.002 -0.002
## 379 platelets_m1 ~ lymph_m1 0.001 -0.001 -0.001 -0.001 -0.001
## 380 ast_m1 ~~ ast_m3 0.001 0.003 0.003 0.004 0.004
## 381 ast_m3 ~ ast_m1 0.001 0.005 0.005 0.005 0.005
## 382 alt_m1 ~ albumin_m1 0.001 0.001 0.001 0.001 0.001
## 383 age_t ~ dhf 0.000 0.002 0.002 0.002 0.002
## 384 ast_m3 ~ lymph_m1 0.000 0.001 0.001 0.001 0.001
## 385 ast_m1 ~ tourn_no_m3 0.000 0.000 0.000 0.000 0.000
## 386 alt_m3 ~ platelets_m1 0.000 0.000 0.000 0.000 0.000
## 387 alt_m3 ~ albumin_m1 0.000 0.000 0.000 0.000 0.000
table2<-parameterEstimates(Blind_fit,standardized=TRUE)%>%as.data.frame()
table2<-table2[!table2$lhs==table2$rhs,]
b<-gettextf('%.3f \n p=%.3f', table2$std.all, digits=table2$pvalue)
fittitles<-fitmeasures(Blind_fit)[c('cfi.robust','tli.robust','rmsea.robust','rmsea.ci.lower.robust' , 'rmsea.ci.upper.robust')]%>%round(3)
semPaths(Blind_fit, layout=ly,
edgeLabels=b,
residuals=FALSE,
style='ram',
what='est',
whatLabels = "std",
cut=0.3,
sizeMan = 10, # Size of manifest variables
sizeMan2=3,edge.label.cex = 0.6,label.cex=1,
nCharNodes = 0,fade=TRUE,
mar = c(5,2,2,2))
text(0,-1.3,paste0(names(fittitles),': ',fittitles,collapse='; '),cex=1.5)
title('Nonsense Blind fit')
Reversed model
To illustrate further how non-sense models also can fit well, look at this model in which all causal relationships are reversed. Look how non-sense it is! But how it fits well!
library(lavaan)
Rev_model="
age_t~alt_m3+wbc_m3+lymph_m3+max_hct_m3+platelets_m3+tourn_no_m3
ast_m3 + alt_m3+platelets_m3~ast_m1
alt_m3 + ast_m3+albumin_m3~alt_m1
wbc_m3 +ast_m3+age_t~wbc_m1
lymph_m3+wbc_m3~lymph_m1
albumin_m3+platelets_m3~albumin_m1
max_hct_m3+age_t+ast_m3~max_hct_m1
platelets_m3+wbc_m3~platelets_m1
tourn_no_m3+age_t~tourn_no_m1
alt_m1+lymph_m1+max_hct_m1+platelets_m1+tourn_no_m1~dhf
ast_m3~~alt_m3
wbc_m3 ~~ lymph_m3+platelets_m3+tourn_no_m3
ast_m1~~alt_m1+tourn_no_m1+max_hct_m1
lymph_m1 ~~ wbc_m1 +tourn_no_m1
platelets_m1 ~~ max_hct_m1+wbc_m1+albumin_m1
"
Rev_fit=sem(model=Rev_model, data=data,std.ov=TRUE,estimator="MLR",fixed.x = FALSE)
fitmeasures(Rev_fit)[c('cfi.robust','tli.robust','rmsea.robust','rmsea.ci.lower.robust' , 'rmsea.ci.upper.robust')]
## cfi.robust tli.robust rmsea.robust
## 0.92711535 0.89578176 0.06897104
## rmsea.ci.lower.robust rmsea.ci.upper.robust
## 0.05701316 0.08094267
modificationindices(Rev_fit,standardized = TRUE)%>%arrange(-mi)
## lhs op rhs mi epc sepc.lv sepc.all sepc.nox
## 1 ast_m3 ~ wbc_m3 20.553 -0.228 -0.228 -0.224 -0.224
## 2 max_hct_m1 ~ lymph_m3 17.689 -0.242 -0.242 -0.240 -0.240
## 3 wbc_m3 ~ ast_m3 17.454 -0.159 -0.159 -0.161 -0.161
## 4 lymph_m3 ~~ max_hct_m1 14.809 -0.185 -0.185 -0.214 -0.214
## 5 tourn_no_m1 ~ wbc_m3 13.461 -0.222 -0.222 -0.218 -0.218
## 6 wbc_m1 ~ age_t 12.672 -0.325 -0.325 -0.319 -0.319
## 7 max_hct_m1 ~ age_t 12.581 0.405 0.405 0.386 0.386
## 8 albumin_m3 ~~ max_hct_m3 12.141 0.147 0.147 0.217 0.217
## 9 ast_m1 ~ max_hct_m1 11.993 0.488 0.488 0.497 0.497
## 10 lymph_m3 ~ max_hct_m1 11.900 -0.180 -0.180 -0.182 -0.182
## 11 ast_m1 ~ alt_m1 11.216 2.519 2.519 2.502 2.502
## 12 dhf ~ max_hct_m1 11.216 -1.849 -1.849 -1.868 -1.868
## 13 ast_m1 ~ dhf 11.216 0.208 0.208 0.209 0.209
## 14 dhf ~ ast_m1 11.216 0.210 0.210 0.209 0.209
## 15 dhf ~ alt_m1 11.216 0.277 0.277 0.273 0.273
## 16 dhf ~ tourn_no_m1 11.215 11.763 11.763 11.752 11.752
## 17 albumin_m3 ~ max_hct_m3 11.138 0.173 0.173 0.174 0.174
## 18 dhf ~ ast_m3 10.500 0.222 0.222 0.222 0.222
## 19 lymph_m1 ~ wbc_m3 10.440 -0.429 -0.429 -0.416 -0.416
## 20 tourn_no_m1 ~ platelets_m1 10.152 -0.199 -0.199 -0.194 -0.194
## 21 ast_m3 ~ lymph_m3 10.120 0.107 0.107 0.108 0.108
## 22 wbc_m1 ~ max_hct_m1 9.906 -0.186 -0.186 -0.191 -0.191
## 23 ast_m3 ~~ wbc_m3 9.711 -0.063 -0.063 -0.137 -0.137
## 24 dhf ~ wbc_m3 9.671 -0.203 -0.203 -0.200 -0.200
## 25 wbc_m3 ~ alt_m1 9.550 -0.119 -0.119 -0.119 -0.119
## 26 wbc_m1 ~ lymph_m1 9.100 0.733 0.733 0.753 0.753
## 27 platelets_m1 ~ ast_m1 8.794 -0.145 -0.145 -0.148 -0.148
## 28 lymph_m1 ~ age_t 8.682 -0.210 -0.210 -0.201 -0.201
## 29 albumin_m1 ~ ast_m3 8.090 -0.168 -0.168 -0.167 -0.167
## 30 dhf ~ platelets_m1 7.976 -0.347 -0.347 -0.338 -0.338
## 31 albumin_m3 ~ age_t 7.942 0.280 0.280 0.271 0.271
## 32 lymph_m1 ~ max_hct_m3 7.881 -0.169 -0.169 -0.168 -0.168
## 33 max_hct_m3 ~ albumin_m3 7.746 0.142 0.142 0.141 0.141
## 34 wbc_m3 ~ platelets_m3 7.585 1.299 1.299 1.293 1.293
## 35 tourn_no_m1 ~ wbc_m1 7.476 -0.165 -0.165 -0.163 -0.163
## 36 age_t ~ lymph_m1 7.310 -0.154 -0.154 -0.161 -0.161
## 37 age_t ~~ lymph_m1 7.280 -0.139 -0.139 -0.173 -0.173
## 38 wbc_m3 ~ tourn_no_m1 7.001 -0.103 -0.103 -0.105 -0.105
## 39 wbc_m3 ~ tourn_no_m3 7.001 -0.199 -0.199 -0.202 -0.202
## 40 age_t ~~ lymph_m3 6.916 0.279 0.279 0.382 0.382
## 41 wbc_m3 ~ ast_m1 6.767 -0.099 -0.099 -0.101 -0.101
## 42 ast_m3 ~ albumin_m3 6.760 -0.166 -0.166 -0.166 -0.166
## 43 ast_m3 ~ albumin_m1 6.760 -0.087 -0.087 -0.087 -0.087
## 44 wbc_m3 ~ alt_m3 6.741 -0.098 -0.098 -0.100 -0.100
## 45 wbc_m1 ~ dhf 6.635 -0.158 -0.158 -0.161 -0.161
## 46 dhf ~ wbc_m1 6.635 -0.163 -0.163 -0.161 -0.161
## 47 dhf ~ lymph_m1 6.635 0.723 0.723 0.731 0.731
## 48 platelets_m1 ~ alt_m1 6.605 -0.125 -0.125 -0.127 -0.127
## 49 tourn_no_m1 ~ ast_m3 6.590 0.152 0.152 0.152 0.152
## 50 lymph_m1 ~~ platelets_m1 6.342 -0.136 -0.136 -0.146 -0.146
## 51 lymph_m1 ~ wbc_m1 6.342 -0.326 -0.326 -0.317 -0.317
## 52 platelets_m1 ~ wbc_m1 6.342 0.626 0.626 0.633 0.633
## 53 tourn_no_m3 ~ lymph_m3 6.256 0.133 0.133 0.134 0.134
## 54 wbc_m3 ~~ lymph_m1 6.253 -0.406 -0.406 -0.621 -0.621
## 55 platelets_m1 ~ ast_m3 6.194 -0.120 -0.120 -0.123 -0.123
## 56 albumin_m1 ~ alt_m3 6.101 -0.146 -0.146 -0.145 -0.145
## 57 alt_m1 ~ tourn_no_m1 5.968 0.153 0.153 0.155 0.155
## 58 alt_m1 ~~ tourn_no_m1 5.829 0.139 0.139 0.148 0.148
## 59 tourn_no_m1 ~ alt_m1 5.829 0.144 0.144 0.142 0.142
## 60 max_hct_m3 ~ ast_m3 5.587 0.121 0.121 0.120 0.120
## 61 wbc_m1 ~ tourn_no_m1 5.541 -0.128 -0.128 -0.130 -0.130
## 62 age_t ~~ alt_m1 5.395 0.090 0.090 0.114 0.114
## 63 max_hct_m1 ~~ wbc_m1 5.295 -0.129 -0.129 -0.137 -0.137
## 64 alt_m1 ~ age_t 5.256 0.112 0.112 0.109 0.109
## 65 platelets_m1 ~ lymph_m1 5.255 -0.126 -0.126 -0.131 -0.131
## 66 tourn_no_m1 ~ platelets_m3 5.163 -0.139 -0.139 -0.136 -0.136
## 67 age_t ~~ ast_m1 5.141 -0.074 -0.074 -0.092 -0.092
## 68 albumin_m3 ~ wbc_m1 5.026 -0.119 -0.119 -0.117 -0.117
## 69 alt_m3 ~ lymph_m3 4.985 -0.078 -0.078 -0.078 -0.078
## 70 wbc_m3 ~ albumin_m3 4.899 0.085 0.085 0.087 0.087
## 71 max_hct_m3 ~~ lymph_m1 4.870 -0.106 -0.106 -0.131 -0.131
## 72 wbc_m3 ~~ tourn_no_m1 4.869 -0.078 -0.078 -0.125 -0.125
## 73 lymph_m3 ~~ tourn_no_m3 4.806 0.105 0.105 0.137 0.137
## 74 ast_m1 ~ tourn_no_m1 4.769 0.345 0.345 0.347 0.347
## 75 lymph_m1 ~ platelets_m1 4.703 -0.141 -0.141 -0.136 -0.136
## 76 max_hct_m3 ~ ast_m1 4.663 0.111 0.111 0.110 0.110
## 77 ast_m3 ~ tourn_no_m3 4.614 0.073 0.073 0.073 0.073
## 78 max_hct_m3 ~ alt_m1 4.606 0.110 0.110 0.109 0.109
## 79 tourn_no_m1 ~ ast_m1 4.516 0.162 0.162 0.161 0.161
## 80 wbc_m1 ~ platelets_m1 4.451 0.316 0.316 0.312 0.312
## 81 ast_m3 ~~ albumin_m1 4.430 -0.066 -0.066 -0.094 -0.094
## 82 wbc_m3 ~~ platelets_m1 4.426 -0.134 -0.134 -0.218 -0.218
## 83 tourn_no_m1 ~ alt_m3 4.305 0.127 0.127 0.126 0.126
## 84 max_hct_m1 ~ tourn_no_m1 4.289 0.127 0.127 0.125 0.125
## 85 lymph_m1 ~~ max_hct_m1 4.183 -0.113 -0.113 -0.119 -0.119
## 86 platelets_m3 ~~ albumin_m3 4.087 0.078 0.078 0.125 0.125
## 87 platelets_m3 ~ albumin_m3 4.033 0.111 0.111 0.113 0.113
## 88 alt_m3 ~ wbc_m3 4.029 0.081 0.081 0.079 0.079
## 89 platelets_m1 ~ lymph_m3 4.027 -0.098 -0.098 -0.101 -0.101
## 90 albumin_m3 ~ platelets_m1 4.004 -0.112 -0.112 -0.109 -0.109
## 91 wbc_m1 ~ max_hct_m3 3.968 -0.108 -0.108 -0.110 -0.110
## 92 max_hct_m3 ~ lymph_m1 3.953 -0.100 -0.100 -0.101 -0.101
## 93 tourn_no_m1 ~ max_hct_m1 3.919 0.121 0.121 0.123 0.123
## 94 albumin_m3 ~ lymph_m3 3.785 -0.101 -0.101 -0.102 -0.102
## 95 ast_m3 ~ platelets_m1 3.781 -0.077 -0.077 -0.075 -0.075
## 96 tourn_no_m1 ~ albumin_m1 3.705 -0.113 -0.113 -0.113 -0.113
## 97 ast_m3 ~~ max_hct_m1 3.679 -0.164 -0.164 -0.244 -0.244
## 98 tourn_no_m3 ~ age_t 3.601 -0.197 -0.197 -0.191 -0.191
## 99 max_hct_m1 ~ lymph_m1 3.591 -0.110 -0.110 -0.110 -0.110
## 100 ast_m3 ~ tourn_no_m1 3.541 0.064 0.064 0.064 0.064
## 101 max_hct_m1 ~ wbc_m1 3.530 -0.112 -0.112 -0.109 -0.109
## 102 albumin_m3 ~~ wbc_m1 3.459 -0.080 -0.080 -0.098 -0.098
## 103 wbc_m3 ~ dhf 3.454 -0.074 -0.074 -0.075 -0.075
## 104 tourn_no_m1 ~ albumin_m3 3.396 -0.109 -0.109 -0.108 -0.108
## 105 albumin_m3 ~ dhf 3.392 0.096 0.096 0.097 0.097
## 106 alt_m1 ~ wbc_m3 3.352 -0.073 -0.073 -0.072 -0.072
## 107 tourn_no_m3 ~~ max_hct_m1 3.269 -0.088 -0.088 -0.108 -0.108
## 108 ast_m3 ~ platelets_m3 3.230 -0.066 -0.066 -0.064 -0.064
## 109 albumin_m3 ~~ wbc_m3 3.191 0.056 0.056 0.102 0.102
## 110 wbc_m1 ~ albumin_m3 3.190 -0.096 -0.096 -0.098 -0.098
## 111 tourn_no_m1 ~ lymph_m1 3.147 0.417 0.417 0.422 0.422
## 112 tourn_no_m1 ~~ wbc_m1 3.147 -0.091 -0.091 -0.097 -0.097
## 113 ast_m3 ~~ tourn_no_m1 3.124 0.056 0.056 0.083 0.083
## 114 max_hct_m1 ~ platelets_m3 3.114 -0.124 -0.124 -0.120 -0.120
## 115 dhf ~ alt_m3 3.095 0.139 0.139 0.139 0.139
## 116 lymph_m1 ~ max_hct_m1 3.053 -0.109 -0.109 -0.109 -0.109
## 117 albumin_m1 ~ tourn_no_m1 2.991 -0.102 -0.102 -0.102 -0.102
## 118 alt_m1 ~ albumin_m1 2.932 -0.067 -0.067 -0.068 -0.068
## 119 dhf ~ max_hct_m3 2.925 -0.138 -0.138 -0.138 -0.138
## 120 max_hct_m1 ~ platelets_m1 2.893 -0.194 -0.194 -0.186 -0.186
## 121 platelets_m3 ~ max_hct_m3 2.863 -0.079 -0.079 -0.081 -0.081
## 122 max_hct_m1 ~~ tourn_no_m1 2.826 0.092 0.092 0.101 0.101
## 123 ast_m3 ~~ lymph_m1 2.774 0.053 0.053 0.075 0.075
## 124 max_hct_m3 ~~ tourn_no_m3 2.676 0.070 0.070 0.102 0.102
## 125 ast_m3 ~~ lymph_m3 2.663 0.046 0.046 0.072 0.072
## 126 ast_m1 ~ platelets_m1 2.643 -0.067 -0.067 -0.066 -0.066
## 127 tourn_no_m1 ~ age_t 2.633 0.174 0.174 0.168 0.168
## 128 lymph_m3 ~~ platelets_m1 2.570 -0.068 -0.068 -0.080 -0.080
## 129 ast_m3 ~ dhf 2.540 0.056 0.056 0.057 0.057
## 130 wbc_m3 ~~ wbc_m1 2.513 0.233 0.233 0.361 0.361
## 131 alt_m3 ~~ lymph_m3 2.411 -0.045 -0.045 -0.069 -0.069
## 132 max_hct_m3 ~~ max_hct_m1 2.356 0.175 0.175 0.226 0.226
## 133 max_hct_m1 ~ max_hct_m3 2.356 0.266 0.266 0.264 0.264
## 134 ast_m3 ~~ wbc_m1 2.310 0.079 0.079 0.115 0.115
## 135 alt_m1 ~ ast_m3 2.280 -0.403 -0.403 -0.407 -0.407
## 136 platelets_m3 ~~ max_hct_m3 2.264 -0.056 -0.056 -0.093 -0.093
## 137 tourn_no_m3 ~ max_hct_m1 2.261 -0.079 -0.079 -0.080 -0.080
## 138 platelets_m1 ~~ ast_m1 2.259 -0.047 -0.047 -0.050 -0.050
## 139 platelets_m1 ~ max_hct_m1 2.258 0.418 0.418 0.434 0.434
## 140 lymph_m1 ~ ast_m3 2.254 0.089 0.089 0.088 0.088
## 141 tourn_no_m3 ~ wbc_m3 2.251 -0.103 -0.103 -0.102 -0.102
## 142 lymph_m3 ~ max_hct_m3 2.248 -0.079 -0.079 -0.079 -0.079
## 143 age_t ~~ alt_m3 2.215 -0.080 -0.080 -0.136 -0.136
## 144 wbc_m1 ~ tourn_no_m3 2.198 -0.078 -0.078 -0.079 -0.079
## 145 age_t ~~ wbc_m1 2.117 -0.130 -0.130 -0.164 -0.164
## 146 max_hct_m3 ~ tourn_no_m3 2.107 0.074 0.074 0.073 0.073
## 147 alt_m3 ~ tourn_no_m3 2.098 -0.051 -0.051 -0.051 -0.051
## 148 alt_m1 ~~ albumin_m1 2.086 -0.053 -0.053 -0.054 -0.054
## 149 max_hct_m3 ~ dhf 2.050 -0.077 -0.077 -0.076 -0.076
## 150 ast_m1 ~ ast_m3 1.999 0.382 0.382 0.383 0.383
## 151 lymph_m3 ~ tourn_no_m3 1.977 0.079 0.079 0.078 0.078
## 152 ast_m1 ~ max_hct_m3 1.947 0.066 0.066 0.066 0.066
## 153 tourn_no_m1 ~~ albumin_m1 1.923 -0.077 -0.077 -0.080 -0.080
## 154 wbc_m3 ~~ alt_m1 1.914 -0.032 -0.032 -0.050 -0.050
## 155 age_t ~~ tourn_no_m1 1.896 -0.207 -0.207 -0.269 -0.269
## 156 lymph_m3 ~~ ast_m1 1.816 -0.044 -0.044 -0.049 -0.049
## 157 platelets_m3 ~ dhf 1.782 0.064 0.064 0.066 0.066
## 158 max_hct_m3 ~ alt_m3 1.751 0.068 0.068 0.067 0.067
## 159 ast_m1 ~ alt_m3 1.713 0.314 0.314 0.315 0.315
## 160 platelets_m1 ~~ tourn_no_m1 1.673 -0.059 -0.059 -0.066 -0.066
## 161 alt_m1 ~ platelets_m1 1.666 -0.054 -0.054 -0.053 -0.053
## 162 alt_m1 ~ albumin_m3 1.628 -0.060 -0.060 -0.060 -0.060
## 163 age_t ~ ast_m3 1.617 -0.174 -0.174 -0.179 -0.179
## 164 age_t ~ ast_m1 1.606 -0.069 -0.069 -0.071 -0.071
## 165 wbc_m3 ~ max_hct_m1 1.603 -0.049 -0.049 -0.051 -0.051
## 166 platelets_m1 ~ age_t 1.595 0.079 0.079 0.079 0.079
## 167 age_t ~ albumin_m1 1.511 0.063 0.063 0.065 0.065
## 168 lymph_m1 ~ tourn_no_m3 1.506 0.085 0.085 0.084 0.084
## 169 tourn_no_m3 ~ lymph_m1 1.490 0.066 0.066 0.067 0.067
## 170 alt_m3 ~~ wbc_m3 1.490 0.026 0.026 0.054 0.054
## 171 albumin_m1 ~ dhf 1.477 -0.076 -0.076 -0.076 -0.076
## 172 dhf ~ albumin_m1 1.477 -0.076 -0.076 -0.076 -0.076
## 173 wbc_m1 ~ lymph_m3 1.438 0.068 0.068 0.070 0.070
## 174 albumin_m1 ~ tourn_no_m3 1.424 -0.071 -0.071 -0.070 -0.070
## 175 ast_m1 ~ platelets_m3 1.413 -0.055 -0.055 -0.054 -0.054
## 176 tourn_no_m1 ~ max_hct_m3 1.407 0.071 0.071 0.071 0.071
## 177 platelets_m3 ~~ max_hct_m1 1.403 -0.050 -0.050 -0.071 -0.071
## 178 lymph_m3 ~ platelets_m3 1.395 -0.069 -0.069 -0.067 -0.067
## 179 tourn_no_m3 ~~ lymph_m1 1.394 0.059 0.059 0.070 0.070
## 180 lymph_m3 ~ ast_m1 1.359 -0.062 -0.062 -0.061 -0.061
## 181 alt_m3 ~~ tourn_no_m3 1.355 -0.034 -0.034 -0.056 -0.056
## 182 platelets_m1 ~ alt_m3 1.346 -0.056 -0.056 -0.058 -0.058
## 183 platelets_m3 ~~ lymph_m3 1.345 -0.049 -0.049 -0.072 -0.072
## 184 alt_m3 ~ platelets_m3 1.327 0.042 0.042 0.041 0.041
## 185 ast_m3 ~~ tourn_no_m3 1.316 0.033 0.033 0.055 0.055
## 186 alt_m1 ~ ast_m1 1.293 0.576 0.576 0.580 0.580
## 187 age_t ~ albumin_m3 1.284 0.109 0.109 0.112 0.112
## 188 ast_m1 ~ lymph_m3 1.278 -0.044 -0.044 -0.044 -0.044
## 189 wbc_m3 ~~ albumin_m1 1.277 0.040 0.040 0.061 0.061
## 190 albumin_m1 ~ alt_m1 1.198 -0.065 -0.065 -0.064 -0.064
## 191 albumin_m3 ~~ lymph_m3 1.183 -0.047 -0.047 -0.063 -0.063
## 192 lymph_m3 ~ albumin_m3 1.159 -0.057 -0.057 -0.056 -0.056
## 193 max_hct_m3 ~ platelets_m3 1.147 -0.056 -0.056 -0.055 -0.055
## 194 lymph_m1 ~ platelets_m3 1.108 -0.066 -0.066 -0.063 -0.063
## 195 alt_m1 ~ platelets_m3 1.100 -0.043 -0.043 -0.042 -0.042
## 196 ast_m1 ~~ albumin_m1 1.094 0.038 0.038 0.039 0.039
## 197 lymph_m3 ~~ wbc_m1 1.085 0.049 0.049 0.055 0.055
## 198 max_hct_m1 ~ ast_m3 1.076 -0.071 -0.071 -0.070 -0.070
## 199 ast_m3 ~~ platelets_m1 1.042 -0.026 -0.026 -0.040 -0.040
## 200 age_t ~~ max_hct_m1 1.028 -0.125 -0.125 -0.162 -0.162
## 201 lymph_m3 ~ alt_m1 1.025 -0.054 -0.054 -0.053 -0.053
## 202 ast_m3 ~ lymph_m1 1.003 0.034 0.034 0.035 0.035
## 203 age_t ~~ albumin_m1 0.998 0.047 0.047 0.058 0.058
## 204 albumin_m1 ~ lymph_m1 0.972 0.058 0.058 0.059 0.059
## 205 ast_m3 ~~ max_hct_m3 0.969 0.027 0.027 0.047 0.047
## 206 ast_m3 ~ max_hct_m3 0.969 0.041 0.041 0.041 0.041
## 207 wbc_m3 ~~ max_hct_m1 0.952 -0.034 -0.034 -0.054 -0.054
## 208 platelets_m1 ~ tourn_no_m1 0.944 -0.049 -0.049 -0.051 -0.051
## 209 lymph_m3 ~ alt_m3 0.942 -0.051 -0.051 -0.051 -0.051
## 210 albumin_m1 ~ age_t 0.935 0.060 0.060 0.058 0.058
## 211 platelets_m3 ~ lymph_m3 0.913 -0.044 -0.044 -0.046 -0.046
## 212 ast_m1 ~ age_t 0.876 -0.041 -0.041 -0.040 -0.040
## 213 dhf ~ tourn_no_m3 0.824 0.070 0.070 0.069 0.069
## 214 wbc_m3 ~ albumin_m1 0.820 0.036 0.036 0.037 0.037
## 215 tourn_no_m3 ~ alt_m3 0.810 -0.048 -0.048 -0.048 -0.048
## 216 age_t ~~ platelets_m3 0.800 -0.057 -0.057 -0.095 -0.095
## 217 alt_m1 ~ wbc_m1 0.797 -0.035 -0.035 -0.035 -0.035
## 218 wbc_m1 ~ ast_m3 0.783 0.052 0.052 0.053 0.053
## 219 albumin_m3 ~ max_hct_m1 0.761 0.045 0.045 0.046 0.046
## 220 max_hct_m3 ~~ alt_m1 0.753 0.027 0.027 0.034 0.034
## 221 alt_m3 ~~ lymph_m1 0.736 -0.028 -0.028 -0.039 -0.039
## 222 lymph_m1 ~ lymph_m3 0.712 0.161 0.161 0.160 0.160
## 223 alt_m3 ~ ast_m3 0.688 0.327 0.327 0.327 0.327
## 224 lymph_m3 ~ tourn_no_m1 0.668 -0.044 -0.044 -0.044 -0.044
## 225 max_hct_m1 ~ wbc_m3 0.658 -0.048 -0.048 -0.047 -0.047
## 226 alt_m1 ~ lymph_m3 0.654 0.031 0.031 0.032 0.032
## 227 albumin_m3 ~~ lymph_m1 0.648 -0.040 -0.040 -0.048 -0.048
## 228 platelets_m3 ~ max_hct_m1 0.640 -0.038 -0.038 -0.039 -0.039
## 229 alt_m3 ~ platelets_m1 0.612 0.030 0.030 0.029 0.029
## 230 wbc_m3 ~ max_hct_m3 0.599 -0.029 -0.029 -0.030 -0.030
## 231 max_hct_m1 ~ alt_m1 0.598 -0.046 -0.046 -0.045 -0.045
## 232 alt_m1 ~~ max_hct_m1 0.598 -0.044 -0.044 -0.047 -0.047
## 233 tourn_no_m3 ~ wbc_m1 0.594 -0.042 -0.042 -0.041 -0.041
## 234 albumin_m3 ~~ tourn_no_m3 0.593 0.034 0.034 0.048 0.048
## 235 alt_m3 ~~ max_hct_m1 0.576 0.030 0.030 0.044 0.044
## 236 wbc_m3 ~ age_t 0.553 -0.086 -0.086 -0.085 -0.085
## 237 alt_m3 ~~ platelets_m1 0.548 0.020 0.020 0.029 0.029
## 238 alt_m3 ~~ platelets_m3 0.546 0.019 0.019 0.035 0.035
## 239 max_hct_m3 ~~ ast_m1 0.544 0.023 0.023 0.029 0.029
## 240 tourn_no_m3 ~ dhf 0.542 0.041 0.041 0.041 0.041
## 241 albumin_m3 ~~ tourn_no_m1 0.541 -0.036 -0.036 -0.045 -0.045
## 242 max_hct_m1 ~ ast_m1 0.536 -0.056 -0.056 -0.055 -0.055
## 243 lymph_m3 ~ albumin_m1 0.531 -0.038 -0.038 -0.038 -0.038
## 244 lymph_m1 ~ albumin_m3 0.528 -0.043 -0.043 -0.043 -0.043
## 245 alt_m3 ~ tourn_no_m1 0.526 -0.025 -0.025 -0.025 -0.025
## 246 tourn_no_m3 ~ alt_m1 0.526 -0.039 -0.039 -0.039 -0.039
## 247 platelets_m3 ~ age_t 0.502 -0.051 -0.051 -0.050 -0.050
## 248 alt_m3 ~~ tourn_no_m1 0.500 -0.023 -0.023 -0.033 -0.033
## 249 wbc_m1 ~ platelets_m3 0.490 0.046 0.046 0.046 0.046
## 250 ast_m1 ~~ wbc_m1 0.490 0.023 0.023 0.024 0.024
## 251 lymph_m1 ~ ast_m1 0.489 0.042 0.042 0.041 0.041
## 252 alt_m3 ~ age_t 0.454 -0.037 -0.037 -0.036 -0.036
## 253 albumin_m1 ~ wbc_m1 0.446 -0.042 -0.042 -0.042 -0.042
## 254 platelets_m3 ~ tourn_no_m3 0.429 0.031 0.031 0.031 0.031
## 255 alt_m3 ~ dhf 0.425 -0.023 -0.023 -0.023 -0.023
## 256 dhf ~ albumin_m3 0.423 0.041 0.041 0.041 0.041
## 257 wbc_m1 ~ ast_m1 0.420 0.034 0.034 0.034 0.034
## 258 lymph_m3 ~~ max_hct_m3 0.398 0.027 0.027 0.036 0.036
## 259 tourn_no_m3 ~ albumin_m3 0.397 0.033 0.033 0.034 0.034
## 260 ast_m3 ~~ alt_m1 0.397 -0.148 -0.148 -0.215 -0.215
## 261 wbc_m3 ~~ ast_m1 0.394 -0.015 -0.015 -0.023 -0.023
## 262 alt_m1 ~ alt_m3 0.379 -0.165 -0.165 -0.167 -0.167
## 263 lymph_m3 ~~ tourn_no_m1 0.377 -0.030 -0.030 -0.035 -0.035
## 264 alt_m3 ~ lymph_m1 0.375 -0.021 -0.021 -0.022 -0.022
## 265 age_t ~ platelets_m1 0.375 0.045 0.045 0.046 0.046
## 266 alt_m1 ~ max_hct_m1 0.366 -0.038 -0.038 -0.039 -0.039
## 267 platelets_m1 ~ tourn_no_m3 0.358 -0.029 -0.029 -0.030 -0.030
## 268 ast_m1 ~ albumin_m1 0.349 0.023 0.023 0.023 0.023
## 269 lymph_m3 ~ platelets_m1 0.348 -0.034 -0.034 -0.033 -0.033
## 270 alt_m1 ~ tourn_no_m3 0.346 0.025 0.025 0.025 0.025
## 271 age_t ~~ wbc_m3 0.334 0.170 0.170 0.322 0.322
## 272 age_t ~~ tourn_no_m3 0.334 3.340 3.340 4.878 4.878
## 273 platelets_m3 ~~ tourn_no_m3 0.307 0.022 0.022 0.035 0.035
## 274 alt_m1 ~~ wbc_m1 0.303 -0.018 -0.018 -0.019 -0.019
## 275 wbc_m1 ~ albumin_m1 0.303 -0.033 -0.033 -0.033 -0.033
## 276 wbc_m1 ~~ albumin_m1 0.303 -0.033 -0.033 -0.033 -0.033
## 277 alt_m1 ~ max_hct_m3 0.297 0.024 0.024 0.024 0.024
## 278 lymph_m3 ~ dhf 0.293 -0.029 -0.029 -0.029 -0.029
## 279 platelets_m1 ~ wbc_m3 0.281 0.060 0.060 0.060 0.060
## 280 albumin_m3 ~ tourn_no_m3 0.278 0.028 0.028 0.028 0.028
## 281 alt_m1 ~~ platelets_m1 0.276 -0.016 -0.016 -0.017 -0.017
## 282 albumin_m3 ~ lymph_m1 0.273 -0.027 -0.027 -0.027 -0.027
## 283 ast_m3 ~~ ast_m1 0.262 -0.172 -0.172 -0.247 -0.247
## 284 max_hct_m1 ~ albumin_m3 0.252 0.029 0.029 0.029 0.029
## 285 max_hct_m1 ~ tourn_no_m3 0.239 -0.029 -0.029 -0.028 -0.028
## 286 albumin_m3 ~ platelets_m3 0.236 0.027 0.027 0.026 0.026
## 287 albumin_m3 ~ alt_m3 0.235 0.033 0.033 0.033 0.033
## 288 platelets_m1 ~ max_hct_m3 0.233 0.028 0.028 0.029 0.029
## 289 platelets_m3 ~ wbc_m3 0.229 0.034 0.034 0.034 0.034
## 290 tourn_no_m3 ~ ast_m1 0.225 -0.025 -0.025 -0.025 -0.025
## 291 platelets_m3 ~~ lymph_m1 0.222 0.021 0.021 0.028 0.028
## 292 max_hct_m1 ~~ albumin_m1 0.222 0.028 0.028 0.029 0.029
## 293 max_hct_m1 ~ albumin_m1 0.222 0.028 0.028 0.027 0.027
## 294 tourn_no_m1 ~ tourn_no_m3 0.216 0.094 0.094 0.093 0.093
## 295 age_t ~~ platelets_m1 0.214 0.021 0.021 0.028 0.028
## 296 alt_m3 ~~ max_hct_m3 0.213 -0.013 -0.013 -0.022 -0.022
## 297 alt_m3 ~~ albumin_m3 0.206 0.017 0.017 0.028 0.028
## 298 tourn_no_m3 ~ max_hct_m3 0.203 0.024 0.024 0.024 0.024
## 299 dhf ~ platelets_m3 0.198 -0.035 -0.035 -0.034 -0.034
## 300 ast_m3 ~~ platelets_m3 0.190 -0.011 -0.011 -0.021 -0.021
## 301 tourn_no_m1 ~ lymph_m3 0.190 0.028 0.028 0.028 0.028
## 302 alt_m3 ~ wbc_m1 0.189 0.020 0.020 0.020 0.020
## 303 platelets_m1 ~ platelets_m3 0.187 0.048 0.048 0.049 0.049
## 304 lymph_m1 ~~ albumin_m1 0.185 0.024 0.024 0.025 0.025
## 305 max_hct_m3 ~ platelets_m1 0.182 0.023 0.023 0.022 0.022
## 306 alt_m3 ~~ ast_m1 0.182 0.055 0.055 0.076 0.076
## 307 lymph_m3 ~~ alt_m1 0.181 0.014 0.014 0.016 0.016
## 308 albumin_m3 ~~ albumin_m1 0.174 0.061 0.061 0.073 0.073
## 309 albumin_m3 ~~ platelets_m1 0.174 -0.017 -0.017 -0.021 -0.021
## 310 dhf ~ lymph_m3 0.171 0.029 0.029 0.029 0.029
## 311 lymph_m1 ~ tourn_no_m1 0.170 0.882 0.882 0.872 0.872
## 312 lymph_m1 ~~ ast_m1 0.170 0.015 0.015 0.016 0.016
## 313 dhf ~ age_t 0.158 0.030 0.030 0.029 0.029
## 314 albumin_m1 ~ wbc_m3 0.152 0.024 0.024 0.024 0.024
## 315 ast_m1 ~ albumin_m3 0.151 0.015 0.015 0.015 0.015
## 316 tourn_no_m3 ~~ alt_m1 0.151 -0.013 -0.013 -0.015 -0.015
## 317 platelets_m3 ~ alt_m3 0.143 0.019 0.019 0.019 0.019
## 318 age_t ~ alt_m1 0.142 0.025 0.025 0.026 0.026
## 319 alt_m3 ~ albumin_m3 0.141 0.016 0.016 0.016 0.016
## 320 max_hct_m3 ~~ wbc_m1 0.140 -0.016 -0.016 -0.020 -0.020
## 321 albumin_m1 ~ albumin_m3 0.137 0.069 0.069 0.068 0.068
## 322 tourn_no_m3 ~ platelets_m1 0.128 -0.020 -0.020 -0.019 -0.019
## 323 tourn_no_m3 ~ albumin_m1 0.128 -0.019 -0.019 -0.019 -0.019
## 324 max_hct_m1 ~ alt_m3 0.122 -0.021 -0.021 -0.021 -0.021
## 325 platelets_m3 ~ tourn_no_m1 0.122 0.016 0.016 0.017 0.017
## 326 ast_m1 ~ wbc_m3 0.108 -0.013 -0.013 -0.013 -0.013
## 327 tourn_no_m3 ~~ wbc_m1 0.105 -0.014 -0.014 -0.017 -0.017
## 328 lymph_m3 ~ wbc_m1 0.105 0.019 0.019 0.019 0.019
## 329 alt_m3 ~ max_hct_m1 0.104 0.015 0.015 0.015 0.015
## 330 lymph_m1 ~ albumin_m1 0.097 -0.019 -0.019 -0.018 -0.018
## 331 max_hct_m3 ~~ platelets_m1 0.091 0.012 0.012 0.015 0.015
## 332 alt_m1 ~ lymph_m1 0.084 -0.011 -0.011 -0.012 -0.012
## 333 max_hct_m3 ~ age_t 0.080 0.033 0.033 0.032 0.032
## 334 alt_m3 ~~ wbc_m1 0.079 -0.010 -0.010 -0.014 -0.014
## 335 tourn_no_m3 ~~ albumin_m1 0.073 -0.013 -0.013 -0.016 -0.016
## 336 ast_m3 ~ age_t 0.068 -0.023 -0.023 -0.022 -0.022
## 337 alt_m3 ~ max_hct_m3 0.064 -0.010 -0.010 -0.010 -0.010
## 338 max_hct_m3 ~ wbc_m1 0.058 0.012 0.012 0.012 0.012
## 339 lymph_m1 ~ alt_m1 0.057 0.014 0.014 0.014 0.014
## 340 alt_m3 ~~ albumin_m1 0.056 -0.008 -0.008 -0.011 -0.011
## 341 ast_m1 ~ tourn_no_m3 0.052 0.010 0.010 0.010 0.010
## 342 platelets_m3 ~ lymph_m1 0.052 0.010 0.010 0.011 0.011
## 343 albumin_m3 ~~ max_hct_m1 0.051 0.011 0.011 0.014 0.014
## 344 tourn_no_m3 ~ platelets_m3 0.051 0.012 0.012 0.012 0.012
## 345 age_t ~ dhf 0.049 0.012 0.012 0.013 0.013
## 346 platelets_m3 ~ ast_m3 0.045 0.012 0.012 0.013 0.013
## 347 albumin_m3 ~~ alt_m1 0.041 -0.008 -0.008 -0.010 -0.010
## 348 wbc_m1 ~ alt_m1 0.040 -0.011 -0.011 -0.011 -0.011
## 349 max_hct_m3 ~ lymph_m3 0.040 -0.010 -0.010 -0.010 -0.010
## 350 tourn_no_m3 ~~ platelets_m1 0.040 -0.008 -0.008 -0.010 -0.010
## 351 albumin_m1 ~ platelets_m3 0.040 0.032 0.032 0.032 0.032
## 352 lymph_m3 ~~ lymph_m1 0.033 0.027 0.027 0.030 0.030
## 353 albumin_m1 ~ lymph_m3 0.031 -0.010 -0.010 -0.010 -0.010
## 354 lymph_m3 ~~ albumin_m1 0.030 -0.009 -0.009 -0.009 -0.009
## 355 wbc_m1 ~ alt_m3 0.030 -0.009 -0.009 -0.009 -0.009
## 356 albumin_m3 ~ ast_m1 0.030 -0.014 -0.014 -0.014 -0.014
## 357 albumin_m1 ~ ast_m1 0.028 -0.010 -0.010 -0.010 -0.010
## 358 platelets_m3 ~~ wbc_m1 0.028 0.006 0.006 0.009 0.009
## 359 alt_m1 ~~ lymph_m1 0.027 -0.006 -0.006 -0.006 -0.006
## 360 wbc_m1 ~ wbc_m3 0.024 0.028 0.028 0.028 0.028
## 361 max_hct_m3 ~ albumin_m1 0.024 0.008 0.008 0.008 0.008
## 362 lymph_m1 ~ alt_m3 0.023 0.009 0.009 0.009 0.009
## 363 tourn_no_m3 ~~ ast_m1 0.020 -0.005 -0.005 -0.006 -0.006
## 364 alt_m3 ~~ alt_m1 0.019 -0.018 -0.018 -0.026 -0.026
## 365 platelets_m3 ~ alt_m1 0.017 -0.010 -0.010 -0.010 -0.010
## 366 albumin_m1 ~ max_hct_m1 0.016 -0.008 -0.008 -0.008 -0.008
## 367 platelets_m3 ~~ alt_m1 0.015 -0.004 -0.004 -0.005 -0.005
## 368 platelets_m3 ~ wbc_m1 0.015 0.006 0.006 0.006 0.006
## 369 ast_m1 ~ lymph_m1 0.010 -0.004 -0.004 -0.004 -0.004
## 370 platelets_m1 ~ albumin_m3 0.007 -0.005 -0.005 -0.005 -0.005
## 371 max_hct_m3 ~ tourn_no_m1 0.007 0.004 0.004 0.004 0.004
## 372 max_hct_m3 ~~ tourn_no_m1 0.007 0.004 0.004 0.005 0.005
## 373 ast_m1 ~ wbc_m1 0.006 -0.003 -0.003 -0.003 -0.003
## 374 albumin_m3 ~~ ast_m1 0.006 0.002 0.002 0.003 0.003
## 375 platelets_m3 ~~ albumin_m1 0.004 -0.015 -0.015 -0.020 -0.020
## 376 platelets_m3 ~~ platelets_m1 0.004 0.004 0.004 0.006 0.006
## 377 wbc_m3 ~~ max_hct_m3 0.004 -0.002 -0.002 -0.004 -0.004
## 378 platelets_m3 ~~ tourn_no_m1 0.003 0.003 0.003 0.004 0.004
## 379 lymph_m3 ~ wbc_m3 0.002 -0.004 -0.004 -0.004 -0.004
## 380 albumin_m3 ~ tourn_no_m1 0.002 -0.002 -0.002 -0.002 -0.002
## 381 max_hct_m3 ~~ albumin_m1 0.002 0.002 0.002 0.003 0.003
## 382 albumin_m1 ~ max_hct_m3 0.001 -0.002 -0.002 -0.002 -0.002
## 383 albumin_m1 ~ platelets_m1 0.001 -0.004 -0.004 -0.004 -0.004
## 384 albumin_m3 ~ ast_m3 0.000 -0.002 -0.002 -0.002 -0.002
## 385 albumin_m3 ~ wbc_m3 0.000 0.001 0.001 0.001 0.001
## 386 lymph_m3 ~ age_t 0.000 0.002 0.002 0.002 0.002
## 387 max_hct_m3 ~ wbc_m3 0.000 0.001 0.001 0.001 0.001
## 388 tourn_no_m3 ~ ast_m3 0.000 -0.001 -0.001 -0.001 -0.001
## 389 alt_m3 ~ albumin_m1 0.000 0.000 0.000 0.000 0.000
## 390 lymph_m3 ~ ast_m3 0.000 -0.001 -0.001 -0.001 -0.001
## 391 tourn_no_m3 ~~ tourn_no_m1 0.000 0.000 0.000 0.001 0.001
## 392 platelets_m3 ~~ ast_m1 0.000 0.000 0.000 0.000 0.000
#17 nodes
ly<-matrix(NA,18,2)
depVar='age_t'
med2=c('ast_m1','alt_m1','wbc_m1','lymph_m1','albumin_m1','max_hct_m1','platelets_m1','tourn_no_m1')
med1=c('ast_m3','alt_m3','wbc_m3','lymph_m3','albumin_m3','max_hct_m3','platelets_m3','tourn_no_m3')
indepVar='dhf'
labels=c()
labels[1]=depVar
ly[1,]=c(1,0)
y=1
for (x in c(1:length(med1))){
ly[y+x,]=c(0.6,(x/8*1.6-1))
labels[(x+y)]<-med1[x]
}
y=9
for (x in c(1:length(med2))){
ly[y+x,]=c(-1,(x/8*1.6-1))
labels[(x+y)]<-med2[x]
}
labels[18]=indepVar
ly[18,]=c(-0.5,1)
table2<-parameterEstimates(Rev_fit,standardized=TRUE)%>%as.data.frame()
table2<-table2[!table2$lhs==table2$rhs,]
b<-gettextf('%.3f \n p=%.3f', table2$std.all, digits=table2$pvalue)
fittitles<-fitmeasures(Rev_fit)[c('cfi.robust','tli.robust','rmsea.robust','rmsea.ci.lower.robust' , 'rmsea.ci.upper.robust')]%>%round(3)
semPaths(Rev_fit, layout=ly,
edgeLabels=b,
residuals=FALSE,
style='ram',
what='est',
whatLabels = "std",
cut=0.3,
sizeMan = 10, # Size of manifest variables
sizeMan2=3,edge.label.cex = 0.6,label.cex=1,
nCharNodes = 0,fade=TRUE,
mar = c(5,2,2,2))
text(0,-1.3,paste0(names(fittitles),': ',fittitles,collapse='; '),cex=1.5)
title('Nonsense Reversed Model')
